Cited by 3,605Angiogenesis and VEGF in CancerLymphatic System and DiseasesCancer, Hypoxia, and Metabolism

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Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

Kim, K. Jin, Li, Bing, Winer, Jane, Armanini, Mark, Gillett, Nancy, Phillips, Heidi S., Ferrara, Napoleone·1993·Nature

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Abstract

The development of new blood vessels (angiogenesis) is required for many physiological processes including embryogenesis, wound healing and corpus luteum formation. Blood vessel neoformation is also important in the pathogenesis of many disorders, particularly rapid growth and metastasis of solid tumours. There are several potential mediators of tumour angiogenesis, including basic and acidic fibroblast growth factors, tumour necrosis factor-alpha and transforming factors-alpha and -beta. But it is unclear whether any of these agents actually mediates angiogenesis and tumour growth in vivo. Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen and an angiogenesis inducer released by a variety of tumour cells and expressed in human tumours in situ. To test whether VEGF may be a tumour angiogenesis factor in vivo, we injected human rhabdomyosarcoma, glioblastoma multiforme or leiomyosarcoma cell lines into nude mice. We report here that treatment with a monoclonal antibody specific for VEGF inhibited the growth of the tumours, but had no effect on the growth rate of the tumour cells in vitro. The density of vessels was decreased in the antibody-treated tumours. These findings demonstrate that inhibition of the action of an angiogenic factor spontaneously produced by tumour cells may suppress tumour growth in vivo.

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Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma
Weidner, N., Semple, J. P., Welch, W. R., & Folkman, J. (1991) · New England Journal of Medicine · doi:10.1056/nejm199101033240101 · Cited by 5,598
Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen
Leung, D. W., Cachianes, G., Kuang, W.-J., Goeddel, D. V., & Ferrara, N. (1989) · Science · doi:10.1126/science.2479986 · Cited by 5,000
Self-citation
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617
What Is the Evidence That Tumors Are Angiogenesis Dependent?
Folkman, J. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.1.4 · Cited by 4,509
Angiogenesis.
Folkman, J., & Shing, Y. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49853-0 · Cited by 2,651
Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
Ferrara, N., & Henzel, W. J. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92678-8 · Cited by 2,269
Self-citation
Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
Plate, K. H., Breier, G., Weich, H. A., & Risau, W. (1992) · Nature · doi:10.1038/359845a0 · Cited by 2,262
Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF
Keck, P. J., Hauser, S. D., Krivi, G. G., Sanzo, K., Warren, T. G., Feder, J., & Connolly, D. T. (1989) · Science · doi:10.1126/science.2479987 · Cited by 2,058
The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
Tischer, E., Mitchell, R., Hartman, T., Silva, M., Gospodarowicz, D., Fiddes, J. C., & Abraham, J. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99049-6 · Cited by 1,988
Molecular and Biological Properties of the Vascular Endothelial Growth Factor Family of Proteins
Ferrara, N., Houck, K. A., Jakeman, L. B., & LEUNG, D. W. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-1-18 · Cited by 1,655
Self-citation

Show all 32 references

Research works printed but not linked: 2

Senger, D., Perruzzi, C. A., Feder, J. & Dvorak, H. F. Cancer Res. 46, 5629 (1986).
Westphal, M. et al. Expl cell. Biol. 55, 152–161 (1987).

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Liao, F., Li, Y., O'Connor, W., Zanetta, L., Bassi, R., Santiago, A., Overholser, J. C., Hooper, A. T., Mignatti, P., Dejana, E., et al. (2000) · PubMed · Cited by 125
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Li, H., Lu, H., Griscelli, F., Opolon, P., Sun, L.-Q., Ragot, T., Legrand, Y., Belin, D., Soria, J., Soria, C., et al. (1998) · Gene Therapy · doi:10.1038/sj.gt.3300742 · Cited by 125
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Hypoxia‐induced vascular endothelial growth factor expression in normal rat astrocyte cultures
Ijichi, A., Sakuma, S., & Tofilon, P. J. (1995) · Glia · doi:10.1002/glia.440140203 · Cited by 125
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Ambs, S., Bennett, W. P., Merriam, W. G., Ogunfusika, M. O., Oser, S. M., Khan, M. H., Jones, R., & Harris, C. C. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.470 · Cited by 124
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Shibuya, M. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009092 · Cited by 129
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Potty, A. S. R., Kourentzi, K. D., Fang, H., Jackson, G. W., Zhang, X., Legge, G. B., & Willson, R. C. (2008) · Biopolymers · doi:10.1002/bip.21097 · Cited by 122
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Ye, W. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.03.015 · Cited by 124
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Faehling, M., Krøll, J., Föhr, K. J., Fellbrich, G., Mayr, U., Trischler, G., & Waltenberger, J. L. (2002) · The FASEB Journal · doi:10.1096/fj.01-0938fje · Cited by 123
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Keshet, E., & Ben‐Sasson, S. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8849 · Cited by 123
Phase II study of cabozantinib in patients with progressive glioblastoma: subset analysis of patients naive to antiangiogenic therapy
Wen, P. Y., Drappatz, J., de Groot, J., Prados, M. D., Reardon, D. A., Schiff, D., Chamberlain, M. C., Mikkelsen, T., Desjardins, A., Holland, J. S., et al. (2017) · Neuro-Oncology · doi:10.1093/neuonc/nox154 · Cited by 121
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Yoshiji, H., Kuriyama, S., & Fukui, H. (2002) · Tumor Biology · doi:10.1159/000069792 · Cited by 119
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Achen, M. G., & Stacker, S. A. (1998) · International Journal of Experimental Pathology · doi:10.1046/j.1365-2613.1998.700404.x · Cited by 123
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Singh, N., Higgins, E., Amin, S. H., Jani, P. D., Richter, E. R., Patel, A., Kaur, R., Wang, J., Ambati, J., Dong, Z., et al. (2006) · Cornea · doi:10.1097/ico.0b013e31802b4201 · Cited by 119
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Signal relays in the VEGF system
Plouët, J. (1999) · Frontiers in bioscience · doi:10.2741/a417 · Cited by 117
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Zhuang, Y., Liu, K., He, Q., Gu, X., Jiang, C., & Wu, J. (2023) · MedComm · doi:10.1002/mco2.203 · Cited by 119
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Xie, Q., Xie, H., Ren, J.-X., Li, L., & Yang, S. (2008) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2008.11.008 · Cited by 117
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Young, H. S., Summers, A., Read, I., Fairhurst, D. A., Plant, D., Campalani, E., Smith, C. H., Barker, J. N. W. N., Detmar, M. J., Brenchley, P. E., et al. (2005) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700096 · Cited by 117
Cardio-Oncology
Bellinger, A. M., Arteaga, C. L., Force, T. L., Humphreys, B. D., Demetri, G. D., Druker, B. J., & Moslehi, J. J. (2015) · Circulation · doi:10.1161/circulationaha.115.010484 · Cited by 119
Cancer-associated fibroblasts support vascular growth through mechanical force
Sewell-Loftin, M. K., Bayer, S. V. H., Crist, E., Hughes, T., Joison, S. M., Longmore, G. D., & George, S. C. (2017) · Scientific Reports · doi:10.1038/s41598-017-13006-x · Cited by 123
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Nakamura, J., Savinov, A. Y., Lü, Q., & Brodie, A. M. (1996) · Endocrinology · doi:10.1210/endo.137.12.8940388 · Cited by 115
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Bitzer, M., Opitz, H., Popp, J., Morgalla, M. H., Gruber, A., Heiß, E., & Voigt, K. (1998) · Acta Neurochirurgica · doi:10.1007/s007010050106 · Cited by 117
Vascular endothelial growth factor production is stimulated by gangliosides and TGF-β isoforms in human glioma cells in vitro
Koochekpour, S., Merzak, A., & Pilkington, G. J. (1996) · Cancer Letters · doi:10.1016/0304-3835(96)04161-4 · Cited by 117
VEGF and VEGF Receptor-1 Concentration in Vestibular Schwannoma Homogenates Correlates to Tumor Growth Rate
Cay??-Thomasen, P., Werther, K., Nalla, A., g-Hansen, T. C. B., Nielsen, H. J., Stangerup, S., & Thomsen, J. (2005) · Otology & Neurotology · doi:10.1097/00129492-200501000-00017 · Cited by 117
Re: Gene Therapy Strategies for Tumor Antiangiogenesis
Stenram, U. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.13.1017-a · Cited by 118
Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs
Hongu, T., Pein, M., Insua-Rodríguez, J., Gutjahr, E., Mattavelli, G., Meier, J., Decker, K., Descot, A., Bozza, M., Harbottle, R., et al. (2022) · Nature Cancer · doi:10.1038/s43018-022-00353-6 · Cited by 118
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Heist, R. S., Zhai, R., Liu, G., Zhou, W., Lin, X., Li, S., Asomaning, K., Lynch, T. J., Wain, J. C., & Christiani, D. C. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.13.5947 · Cited by 116
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Lei, H., An, P., Shumei, S., Xiaoying, L., Luowen, H., Jian, W., Lin, M., Meisheng, L., Junshan, Y., & Chengchao, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203103200 · Cited by 116
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Hotchkiss, K. A., Basile, C., Spring, S. C., Bonuccelli, G., Lisanti, M. P., & Terman, B. I. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.12.025 · Cited by 116
LY317615 decreases plasma VEGF levels in human tumor xenograft-bearing mice
Keyes, K. A., Mann, L. L., Sherman, M., Galbreath, E. J., Schirtzinger, L., Ballard, D. W., Chen, Y.-F., Iversen, P. W., & Teicher, B. A. (2004) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-003-0713-x · Cited by 116
Vascular Endothelial Growth Factor-Delivery Systems for Cardiac Repair: An Overview
Simón‐Yarza, T., Formiga, F. R., Tamayo, E., Pelacho, B., Prósper, F., & Blanco‐Prieto, M. J. (2012) · Theranostics · doi:10.7150/thno.3682 · Cited by 117
A Role for the Interferon‐Inducible Protein 10 in Inhibition of Angiogenesis by Interleukin‐12
Angiolillo, A. L., Sgadari, C., & Tosato, G. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb52664.x · Cited by 116
Angiostatin inhibits endothelial and melanoma cellular invasion by blocking matrix-enhanced plasminogen activation
Stack, M. S., Gately, S. T., Bafetti, L. M., Enghild, J. J., & Soff, G. A. (1999) · Biochemical Journal · doi:10.1042/bj3400077 · Cited by 116
Antiangiogenic and anticancer potential of unsaturated vitamin E (tocotrienol)
Miyazawa, T., Shibata, A., Sookwong, P., Kawakami, Y., Eitsuka, T., Asai, A., Oikawa, S., & Nakagawa, K. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.09.003 · Cited by 115
Angiogenesis in hepatocellular carcinoma as evaluated by CD34 immunohistochemistry
Kimura, H., Nakajima, T., Kagawa, K., Deguchi, T., Kakusui, M., Katagishi, T., Okanoue, T., Kashima, K., & Ashihara, T. (1998) · Liver International · doi:10.1111/j.1600-0676.1998.tb00121.x · Cited by 115
Oncogenic transformation induces tumor angiogenesis: a role for PAR1 activation
Yin, Y., Salah, Z., Maoz, M., Ram, S. C. E., Ochayon, S., Neufeld, G., Katzav, S., & Bar‐Shavit, R. (2003) · The FASEB Journal · doi:10.1096/fj.02-0316com · Cited by 117
Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro
Zippo, A., Robertis, A. D., Bardelli, M., Galvagni, F., & Oliviero, S. (2004) · Blood · doi:10.1182/blood-2003-11-3827 · Cited by 115
Vascular Endothelial Growth Factor: A Therapeutic Target for Tumors of the Ewing's Sarcoma Family
Dalal, S., Berry, A. M., Cullinane, C. J., Mangham, D. C., Grimer, R. J., Lewis, I. J., Johnston, C., Laurence, V., & Burchill, S. A. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1201 · Cited by 115
Synthesis and Initial SAR Studies of 3,6-Disubstituted Pyrazolo[1,5-a]pyrimidines: A New Class of KDR Kinase Inhibitors
Fraley, M. E., Hoffman, W. F., Rubino, R. S., Hungate, R. W., Tebben, A. J., Rutledge, R. Z., McFall, R. C., Huckle, W. R., Kendall, R. L., Coll, K. E., et al. (2002) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(02)00525-5 · Cited by 115
Highly metastatic human prostate cancer growing within the prostate of athymic mice overexpresses vascular endothelial growth factor.
Balbay, M. D., Pettaway, C. A., Kuniyasu, H., Inoue, K., Ramirez, E., Li, E., Fidler, I. J., & Dinney, C. P. (1999) · PubMed · Cited by 115
EMMPRIN promotes angiogenesis through hypoxia-inducible factor-2α–mediated regulation of soluble VEGF isoforms and their receptor VEGFR-2
Bougatef, F., Quemener, C., Kellouche, S., Naïmi, B., Podgorniak, M.-P., Millot, G., Gabison, E. E., Calvo, F. M., Dosquet, C., Lebbé, C., et al. (2009) · Blood · doi:10.1182/blood-2009-04-217380 · Cited by 116
Endocrine gland–derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis
LeCouter, J. E., Lin, R., & Ferrara, N. (2002) · Nature Medicine · doi:10.1038/nm0902-913 · Cited by 114
Self-citation
Expression of Vascular Endothelial Growth Factors and Their Receptors in and around Intracranial Arteriovenous Malformations
Koizumi, T., Shiraishi, T., Hagihara, N., Tabuchi, K., Hayashi, T., & Kawano, T. (2002) · Neurosurgery · doi:10.1097/00006123-200201000-00020 · Cited by 114
Angiopoietin-1, Unlike Angiopoietin-2, Is Incorporated into the Extracellular Matrix via Its Linker Peptide Region
Xu, Y., & Yu, Q. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103661200 · Cited by 117
Serum VEGF levels in women with a benign breast tumor or breast cancer
Salvén, P., Perhoniemi, V. J., Tykkä, H., Mäenpää, H. O., & Joensuu, H. (1999) · Breast Cancer Research and Treatment · doi:10.1023/a:1006178517505 · Cited by 114
Restoration of functional defects in peripheral blood mononuclear cells isolated from cancer patients by thiol antioxidants alpha-lipoic acid and N-acetyl cysteine
Mantovani, G., Macci�, A., Melis, G. B., Mura, L., Massa, E., & Mudu, M. C. (2000) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(20000615)86:6 · Cited by 51
Differential downregulation of vascular endothelial growth factor by dexamethasone in normoxic and hypoxic rat glioma cells
Machein, Kullmer, Rönicke, Machein, Krieg, Damert, Breier, Risau, & Plate (1999) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1999.00166.x · Cited by 113
HIF-1 is involved in high glucose-induced paracellular permeability of brain endothelial cells
Yan, J., Zhang, Z., & Shi, H. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0731-5 · Cited by 117
Bevacizumab and Glioblastoma
Kim, M. M., Umemura, Y., & Leung, D. (2018) · The Cancer Journal · doi:10.1097/ppo.0000000000000326 · Cited by 118
Structure and Inhibitory Effects on Angiogenesis and Tumor Development of a New Vascular Endothelial Growth Inhibitor
Zilberberg, L., Shinkaruk, S., Lequin, O., Rousseau, B., Hagedorn, M., Costa, F., Caronzolo, D., Balke, M., Canron, X., Convert, O., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304435200 · Cited by 113
Vascular endothelial growth factor affects permeability of brain microvessel endothelial cells in vitro
Wang, W., Merrill, M. J., & BORCHARDT, R. T. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.6.c1973 · Cited by 113
Angiogenesis in normal and neoplastic ovaries
Ramakrishnan, S., Subramanian, I. V., Yokoyama, Y., & Geller, M. A. (2005) · Angiogenesis · doi:10.1007/s10456-005-9001-1 · Cited by 112
Polyethylenimine/small interfering RNA‐mediated knockdown of vascular endothelial growth factor in vivo exerts anti‐tumor effects synergistically with Bevacizumab
Höbel, S., Koburger, I., John, M., Czubayko, F., Hadwiger, P., Vornlocher, H., & Aigner, A. M. (2010) · The Journal of Gene Medicine · doi:10.1002/jgm.1431 · Cited by 112
Quantitative immunohistological analysis of the microvasculature in untreated human glioblastoma multiforme
Wesseling, P., van der Laak, J. A. W. M., de Leeuw, H., Ruiter, D. J., & Burger, P. C. (1994) · Journal of neurosurgery · doi:10.3171/jns.1994.81.6.0902 · Cited by 113
Angiogenesis in Ischemic Disease
Risau, W., & Marti, H. H. (1999) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615552 · Cited by 111
Monoclonal antibodies to vascular endothelial growth factor‐D block its interactions with both VEGF receptor‐2 and VEGF receptor‐3
Achen, M. G., Roufail, S., Domagala, T., Catimel, B., Nice, E. C., Geleick, D., Murphy, R., Scott, A. M., Caesar, C., Mäkinen, T., et al. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01257.x · Cited by 112
Role of Vascular Endothelial Growth Factor/Vascular Permeability Factor in the Pathogenesis of Kaposi's Sarcoma-Associated Herpesvirus-Infected Primary Effusion Lymphomas
Aoki, Y., & Tosato, G. (1999) · Blood · doi:10.1182/blood.v94.12.4247 · Cited by 113
Treatment of human metastatic transitional cell carcinoma of the bladder in a murine model with the anti-vascular endothelial growth factor receptor monoclonal antibody DC101 and paclitaxel.
Inoue, K., Slaton, J. W., Davis, D. W., Hicklin, D. J., McConkey, D. J., Karashima, T., Radinsky, R., & Dinney, C. P. (2000) · PubMed · Cited by 112
Vascular development and disorders: Molecular analysis and pathogenic insights
Carmeliet, P., & Collen, D. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00936.x · Cited by 114
Synergistic anti-tumor effects of combined gemcitabine and cisplatin nanoparticles in a stroma-rich bladder carcinoma model
Zhang, J., Miao, L., Guo, S., Zhang, Y., Zhang, L., Satterlee, A., Kim, W. Y., & Huang, L. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.03.016 · Cited by 110

Authors: Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S., & Ferrara, N.
Affiliations: Genentech (US)
ORCID: Li, Bing
Armanini, Mark
Phillips, Heidi S.
Ferrara, Napoleone
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1993-04
Volume: 362
Issue: 6423
Pages: 841-844
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/362841a0
OpenAlex: W1969328947
Cited by: 3,605
References: 32
Citations by year: 2026: 22 · 2025: 25 · 2024: 43 · 2023: 47 · 2022: 53 · 2021: 55 · 2020: 55 · 2019: 54 · 2018: 89 · 2017: 101 · 2016: 81 · 2015: 78 · 2014: 98 · 2013: 110 · 2012: 137
FWCI: 32.75
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: vascular endothelial growth factor, angiogenesis, tumor angiogenesis, tumor growth inhibition, monoclonal antibodies, rhabdomyosarcoma, glioblastoma, leiomyosarcoma, tumor vasculature, nude mice, tumour metastasis
MeSH terms: Animals, Antibodies, Monoclonal, Cell Division, Female, Glioblastoma, Humans, Leiomyosarcoma, Lymphokines, Mice, Nude, Neoplasm Transplantation, Neoplasms, Experimental, Neovascularization, Pathologic, Rhabdomyosarcoma, Tumor Cells, Cultured, Endothelial Growth Factors, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Mice

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Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

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