The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Molecular characterization of a peripheral receptor for cannabinoids
Abstract
The major active ingredient of marijuana, delta 9-tetrahydrocannabinol (delta 9-THC), has been used as a psychoactive agent for thousands of years. Marijuana, and delta 9-THC, also exert a wide range of other effects including analgesia, anti-inflammation, immunosuppression, anticonvulsion, alleviation of intraocular pressure in glaucoma, and attenuation of vomiting. The clinical application of cannabinoids has, however, been limited by their psychoactive effects, and this has led to interest in the biochemical bases of their action. Progress stemmed initially from the synthesis of potent derivatives of delta 9-THC, and more recently from the cloning of a gene encoding a G-protein-coupled receptor for cannabinoids. This receptor is expressed in the brain but not in the periphery, except for a low level in testes. It has been proposed that the nonpsychoactive effects of cannabinoids are either mediated centrally or through direct interaction with other, non-receptor proteins. Here we report the cloning of a receptor for cannabinoids that is not expressed in the brain but rather in macrophages in the marginal zone of spleen.
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In the citing paper
“The primary psychoactive constituent of cannabis, THC (Mechoulam and Gaoni, 1965), and certain other plant-derived or synthetic psychoactive cannabinoids bind cannabinoid (CB 1 and CB 2 ) receptors (Devane et al, 1988;Matsuda et al, 1990;Munro et al, 1993).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Munro et al, 1993
In the citing paper
“CB1 and CB2 receptors exhibit disparate anatomical distributions.3”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [3]
In the citing paper
“Both CB12 and CB23 receptors are G-coupled protein receptors that are negatively coupled to adenylate cyclase.”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [3]
Citations
Cites
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
Cannabinoid receptor localization in brain.
Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M. R., Melvin, L. S., de Costa, B. R., & Rice, K. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1932 · Cited by 2,321
Collins, S. (1987) · Blood · doi:10.1182/blood.v70.5.1233.1233 · Cited by 1,189
The probable arrangement of the helices in G protein‐coupled receptors.
Baldwin, J. M. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05814.x · Cited by 968
Molecular cloning of a human cannabinoid receptor which is also expressed in testis
Gérard, C. M., Mollereau, C., Vassart, G., & Parmentier, M. (1991) · Biochemical Journal · doi:10.1042/bj2790129 · Cited by 698
An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2
Seed, B. (1987) · Nature · doi:10.1038/329840a0 · Cited by 674
Mailleux, P., & Vanderhaeghen, J. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90409-u · Cited by 660
Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor.
Zhou, Q. Y., Li, C., Olah, M. E., Johnson, R. A., Stiles, G. L., & Civelli, O. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7432 · Cited by 659
ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM
Simmons, D., Makgoba, M. W., & Seed, B. (1988) · Nature · doi:10.1038/331624a0 · Cited by 616
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Research works printed but not linked: 8
- Dewey, W. L. Pharmac. Rev. 38, 151–178 (1986).
- Hollister, L. E. Pharmac. Rev. 38, 1–20 (1986).
- Razdan, R. K. Pharmac. Rev. 38, 75–149 (1986).
- Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S. & Howlett, A. C. Molec. Pharmacol. 34, 605–613 (1988).
- Martin, B. R. Pharmac. Rev. 38, 45–74 (1986).
- Reichman, M., Nen, W. & Hokin, L. E. Molec. Pharmac. 40, 547–555 (1991).
- Munson, A. E. & Fehr, K. O. in Adverse Health and Behavioral Consequences of Cannabis Use (eds Fehr, K. O. & Kalant H.) 257–353 (Addiction Research Foundation, Toronto, 1983).
- Robinson, A. P., White, T. M. & Mason, D. W. Immunology 57, 239–247 (1986).
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A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Lindemann, L., Jaeschke, G., Michalon, A., Vieira, E., Honer, M., Spooren, W., Porter, R., Hartung, T., Kolczewski, S., Büttelmann, B., et al. (1909) · JAMA · doi:10.1001/jama.1909.02550020033007 · Cited by 7,889
Ledent, C. A., Valverde, O., Cossu, G., Petitet, F., Aubert, J.-F., Beslot, F., Böhme, G. A., Impérato, A., Pedrazzini, T., Roques, B. P., et al. (1999) · Science · doi:10.1126/science.283.5400.401 · Cited by 3,628
Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
Howlett, A. C., Barth, F., Bonner, T. I., Cabral, G., Casellas, P., Devane, W. A., Felder, C. C., Herkenham, M., Mackie, K., Martin, B. R., et al. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.161 · Cited by 2,819
Gut microbiome and health: mechanistic insights
de Vos, W. M., Tilg, H., Van Hul, M., & Cani, P. D. (2022) · Gut · doi:10.1136/gutjnl-2021-326789 · Cited by 2,388
Metadata
- Authors
- Munro, S., Thomas, K. L., & Abu-Shaar, M.
- Affiliations
- MRC Laboratory of Molecular Biology (GB)
- Venue
- Nature
- Published
- 1993-09
- Volume
- 365
- Issue
- 6441
- Pages
- 61-65
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2056188558
- Cited by
- 5,092
- References
- 30
- Citations by year
- 2026: 76 · 2025: 119 · 2024: 165 · 2023: 172 · 2022: 198 · 2021: 244 · 2020: 212 · 2019: 184 · 2018: 169 · 2017: 188 · 2016: 182 · 2015: 175 · 2014: 188 · 2013: 201 · 2012: 202
- FWCI
- 39.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- cannabinoid receptors, delta-9-tetrahydrocannabinol, peripheral cannabinoid receptors, macrophages, receptor cloning, G protein-coupled receptors, immunosuppression, anti-inflammatory activity
- MeSH terms
- Amides, Amino Acid Sequence, Animals, Arachidonic Acids, Base Sequence, Brain, Cannabinoids, Cloning, Molecular, DNA, Fatty Acids, Unsaturated, Humans, Macrophages, Molecular Sequence Data, Morpholines, Naphthalenes, Receptors, Drug, RNA, Spleen, Tumor Cells, Cultured, Receptors, Cannabinoid, Benzoxazines, Rats, Polyunsaturated Alkamides, Endocannabinoids
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