Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

Zhang, Faming, Strand, Arne, Robbins, David, Cobb, Melanie H., Goldsmith, Elizabeth J.·1994·Nature
DOI 10.1038/367704a0

Cited by (602)

Items 501–600 of 602

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  3. Overview of Protein Folds in the Immune System
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  6. Probing conformational dynamics to understand kinase inhibition
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  7. Peptidomimetic and Nonpeptide Drug Discovery: Receptor, Protease, and Signal Transduction Therapeutic Targets
    Tomi K. Sawyer · 2007 · Elsevier eBooks
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  9. Kinetic network model to explain gain-of-function mutations in ERK2 enzyme
    Mikita M. Misiura, Anatoly B. Kolomeisky · 2019 · The Journal of Chemical Physics
  10. Principles of Macromolecular X‐Ray Crystallography
    Alison Burgess Hickman, David R. Davies · 1997 · Current Protocols in Protein Science
  11. MOLECULAR DYNAMICS AND FREE ENERGY ANALYSES OF ERK2–PYRAZOLYLPYRROLE INHIBITORS INTERACTIONS: INSIGHT INTO STRUCTURE-BASED LIGAND DESIGN
    Jin‐Hui Zhan, Xi Zhao, Xuri Huang, Chia‐Chung Sun · 2009 · Journal of Theoretical and Computational Chemistry
  12. Comparative Analysis of Docking Motifs in MAP-Kinases and Nuclear Receptors
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  13. Ligand interaction scan (LIScan) in the study of ERK8
    Oran Erster, Rony Seger, Mordechai Liscovitch · 2010 · Biochemical and Biophysical Research Communications
  14. Isolation and characterization of mutants of human mitogen‐activated protein kinase (ERK2)
    Indira Krishnan, Eleonora D. Kovacs, Philip M. Sass · 1994 · FEBS Letters
  15. Inhibition of protein-protein interactions with low molecular weight compounds.
    Marilyn M. Matthews, David J. Weber, Paul S. Shapiro, Andrew Coop, Alexander D. MacKerell · 2008 · PubMed
  16. Tyrosine nitration of human ERK1 introduces an intra-hydrogen bond by molecular dynamics simulations
    Wu Xu, Yuanya Zhang, Oliver Y. Achi, Kathleen D. Knierim, Justin G. Hanks, Yingchun Wang · 2019 · Structural Chemistry
  17. Characterization of Conformational Patterns in Active and Inactive Forms of Kinases Using Protein Blocks Approach
    G. Agarwal, Divya Dinesh, Narayanaswamy Srinivasan, Alexandre G. de Brevern · 2010
  18. A Toolbox of Structural Biology and Enzyme Kinetics Reveals the Case for ERK Docking Site Inhibition
    Rachel M. Sammons, Kevin N. Dalby · 2020 · Springer eBooks
  19. Mitogen-activated protein kinase (MAPK) cascades—A yeast perspective
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  20. Hydrogen/Deuterium Exchange Mass Spectrometry for Protein Higher-Order Structure Characterization
    Hui Wei, Adrienne A. Tymiak, Guodong Chen · 2013 · Springer eBooks
  21. Enzymes: Chemistry and biochemistry
    Jonathan Jeffery · 1995 · Birkhäuser Basel eBooks
  22. Signal Transduction to the Nucleus by MAP Kinase
    Roger J. Davis · 2000 · Humana Press eBooks
  23. The MAP Kinases and Their Role in Mast Cells and Basophils
    Cheng Zhang, Michael A. Beaven · 1999 · Springer eBooks
  24. Is allostery a fuzzy concept?
    Veronica Morea, Francesco Angelucci, Andrea Bellelli · 2024 · FEBS Open Bio
  25. Drude polarizable force field for phosphorylated polypeptides and proteins
    Laura I. Gil Pineda, Candace J. Miller, Alexander D. MacKerell, Justin A. Lemkul · 2025 · Biophysical Journal
  26. Developing Kinase Inhibitors Using Computer-Aided Drug Design Approaches
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  27. Oxidative Stress and Mitochondrial Dysfunction in Neurodegeneration of Transmissible Spongiform Encephalopathies (TSEs)
    Boe‐Hyun Kim, Jae-II Kim, Richard I. Carp, Yong‐Sun Kim · 2005 · Springer eBooks
  28. A Basic Residue, Lys 782, Composes Part of the ATP-Binding Site on the Epidermal Growth Factor Receptor Tyrosine Kinase
    Candice K. Klingbeil, Gordon N. Gill · 1999 · Archives of Biochemistry and Biophysics
  29. Plant Protein Kinase and Protein-Protein Interaction
    2014 · Journal of Biodiversity Bioprospecting and Development
  30. cAMP‐dependent protein kinase: structure, function and control
    Dirk Bossemeyer, Volker Kinzel, Jennifer Reed · 1996
  31. Kinobead Profiling Reveals Reprogramming of B-cell Receptor Signaling in Response to Therapy Within Primary Chronic Lymphocytic Leukemia Cells
    AJ Linley, LI Karydis, A Mondru, A D’Avola, S Cicconi, R Griffin, F Forconi, Andrew R. Pettitt, N Kalakonda, A Rawstron et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  32. Protein Kinase Inhibitors
    Jerry L. Adams, James M. Veal, Lisa M. Shewchuk · 2008 · Protein Science Encyclopedia
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    Boštjan Kobe, Bruce E. Kemp · 2003 · Elsevier eBooks
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    obert Roskoski · 2012
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    Marco Betz, Martin Vogtherr, Ulrich Schieborr, Bettina Elshorst, S. Grimme, Barbara Pescatore, Thomas Langer, Krishna Saxena, Harald Schwalbe · 2007 · Chemical biology
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    Ainhoa I. Callejo, Emilio Casanova, Pedro Calvo, Román Galetto, José Carlos Rodríguez-Rey, Miguel A. Chinchetru · 2004 · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
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    Marco A. Ramos, Rosana Sánchez‐López, Felipe Olvera, Alejandro C. Alagon · 2002 · Experimental Parasitology
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    Peter van der Geer, Tony R. Hunter, Anne Lindberg · 1994
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    Dajun Sang, Sudarshan Pinglay, Sezen Vatansever, Hua Jane Lou, Benjamin E. Turk, Zeynep Hulya Gumus, Liam J. Holt · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
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  47. Erk1/2
    Melanie H. Cobb · 1995 · Elsevier eBooks
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    Jelena Popić · 2012
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    Laurel Hoffman · 2011
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  69. Molecular Basis for Phosphate Signaling by Prokaryotic and Eukaryotic Phosphatases
    David Critton · 2011
  70. Mitogen-activated protein kinase
    Professor Dietmar Schomburg, Ida Schomburg, Antje Chang · 2009 · Springer eBooks
  71. Protein kinase (MAPK)
    Professor Dietmar Schomburg, Ida Schomburg, Antje Chang · 2007 · Springer eBooks
  72. Protein Kinases
    Janusz M. Sowadski, Linda F. Epstein · 2001 · Encyclopedia of Life Sciences
  73. Cross family comparative proteomic study and molecular phylogeny of MAP kinases in plants
    Swati Singh, Anoop Chaturvedi, Ashutosh Mani · 2015 · Interdisciplinary Sciences Computational Life Sciences
  74. Does mitogen-activated-protein kinase have a role in insulin action?
    Richard M. Denton, Jeremy M. Tavaré · 1995 · Springer eBooks
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    Θεοδώρα Σολοβού · 2022
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    Jake W. Anderson, David Vaisar, David N. M. Jones, Laurel M. Pegram, Guy P. A. Vigers, Huifen Chen, John G. Moffat, Natalie G. Ahn · 2024 · eLife
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    Yiming Wang, Fang Wan, Zhangtao Chen, Jonathan Nukpezah, Tom Pan, Kathleen J. Stebe, César de la Fuente‐Núñez, Ravi Radhakrishnan · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
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    J.W. Ligterink · 2000
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    Lepore Signorile, Martina, Candida Fasano, Giovanna Forte, Katia De Marco, Paola Sanese, Vittoria Disciglio, Elisabetta Di Nicola, Antonino Pantaleo, Cristiano Simone, Valentina Grossi · 2023 · Figshare
  83. Target Hyperactive ERK Signaling for Cancer Therapy
    Jiajun Yap, Jiancheng Hu · 2025 · Springer eBooks
  84. Molecular basis of mitogen-activated protein kinase ERK2 activation by its upstream kinase MEK1
    Jill von Velsen, Pauline Juyoux, Nicola Piasentin, Hayden Fisher, Karine Lapouge, Oscar Vadas, Francesco Luigi Gervasio, Matthew W. Bowler · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  85. Mechanistic insight into the dual phosphorylation of ERK1 and ERK2 by MEK1
    Ying Sun, Cheng Peng, Shengjie Liu, Fayang Zhou, Gaoxingyu Huang, Jianbo Wang, Qi Hu · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  86. Étude structurale et fonctionnelle d’une sérine/thréonine kinase de staphylococcus aureus
    Patricia Paracuellos · 2009
  87. Motifs de régulation et dynamique de la voie Mitogen Activated Protein Kinase lors de la transition G2/M des ovocytes de Xénope
    Rémy Beaujois · 2010
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  89. Structural and dynamic insights into the allosteric activation of p38α MAP kinase via specific docking interactions
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  90. Molecular basis of mitogen-activated protein kinase ERK2 activation by its upstream kinase MEK1
    Jill von Velsen, Pauline Juyoux, Nicola Piasentin, Hayden Fisher, Karine Lapouge, Oscar Vadas, Francesco Luigi Gervasio, Matthew W. Bowler · 2026 · eLife
  91. Molecular basis of mitogen-activated protein kinase ERK2 activation by its upstream kinase MEK1
    Jill von Velsen, Pauline Juyoux, Nicola Piasentin, Hayden Fisher, Karine Lapouge, Oscar Vadas, Francesco Luigi Gervasio, Matthew W. Bowler · 2026 · eLife
  92. BindingDB Entry 50038031: Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk.
    BindingDB · 2012 · UC San Diego
  93. BindingDB Entry 3596: The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase.
    BindingDB · 2011 · UC San Diego
  94. BindingDB Entry 6309: A unique inhibitor binding site in ER K1/2 is associated with slow binding kinetics
    BindingDB · 2014 · UC San Diego
  95. BindingDB Entry 50016520: Identification of novel extracellular signal-regulated kinase docking domain inhibitors.
    BindingDB · 2009 · UC San Diego
  96. BindingDB Entry 1932: Structural basis of inhibitor selectivity in MAP kinases.
    BindingDB · 2007 · UC San Diego
  97. BindingDB Entry 50038225: Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1).
    BindingDB · 2012 · UC San Diego
  98. BindingDB Entry 50007037: Structure-based design of a potent, selective, and irreversible inhibitor of the catalytic domain of the erbB receptor subfamily of protein tyrosine kinases.
    BindingDB · 2009 · UC San Diego
  99. BindingDB Entry 50016960: Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative.
    BindingDB · 2009 · UC San Diego
  100. BindingDB Entry 50006430: Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor.
    BindingDB · 2009 · UC San Diego