The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Nuclear protein CBP is a coactivator for the transcription factor CREB
Abstract
The transcription factor CREB binds to a DNA element known as the cAMP-regulated enhancer (CRE). CREB is activated through phosphorylation by protein kinase A (PKA), but precisely how phosphorylation stimulates CREB function is unknown. One model is that phosphorylation may allow the recruitment of coactivators which then interact with basal transcription factors. We have previously identified a nuclear protein of M(r)265K, CBP, that binds specifically to the PKA-phosphorylated form of CREB. We have used fluorescence anisotropy measurements to define the equilibrium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus. The activation domain of CBP interacts with the basal transcription factor TFIIB through a domain that is conserved in the yeast coactivator ADA-1 (ref. 8). Consistent with its role as a coactivator, CBP augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Once activated by the CaMK cascade, CaMKIV is able to phosphorylate another important nuclear factor, CREB binding protein/p300 (CBP, gene name CREBBP) (Impey et al., 2002; Kwok et al., 1994).”
From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Kwok et al., 1994
Citations
Cites
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
Gonzalez, G. A., & Montminy, M. (1989) · Cell · doi:10.1016/0092-8674(89)90013-5 · Cited by 2,464
Phosphorylated CREB binds specifically to the nuclear protein CBP
Chrivia, J. C., Kwok, R. P. S., Lamb, N., Hagiwara, M., Montminy, M. R., & Goodman, R. H. (1993) · Nature · doi:10.1038/365855a0 · Cited by 2,052
Self-citationGuan, K., & Dixon, J. (1991) · Analytical Biochemistry · doi:10.1016/0003-2697(91)90534-z · Cited by 1,735
Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.
Montminy, M., Sevarino, K. A., Wagner, J. A., Mandel, G., & Goodman, R. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.18.6682 · Cited by 1,385
Self-citationGonzalez, G. A., Yamamoto, K. K., Fischer, W. H., Karr, D., Menzel, P., Biggs, W., Vale, W., & Montminy, M. (1989) · Nature · doi:10.1038/337749a0 · Cited by 875
A cyclic AMP- and phorbol ester-inducible DNA element
Comb, M. J., Birnberg, N. C., Seasholtz, A. F., Herbert, E., & Goodman, H. M. (1986) · Nature · doi:10.1038/323353a0 · Cited by 741
Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA
Hoeffler, J. P., Meyer, T. E., Yun, Y., Jameson, J. L., & Habener, J. F. (1988) · Science · doi:10.1126/science.2974179 · Cited by 731
Transcription activation by the adenovirus E1a protein
Lillie, J. W., & Green, M. R. (1989) · Nature · doi:10.1038/338039a0 · Cited by 617
Self-citationBerger, S. L., Piña, B., Silverman, N., Marcus, G. A., Agapite, J., Regier, J. L., Triezenberg, S. J., & Guarente, L. (1992) · Cell · doi:10.1016/0092-8674(92)90100-q · Cited by 435
Goodrich, J., Hoey, T., Thut, C., Admon, A., & Tjian, R. (1993) · Cell · doi:10.1016/0092-8674(93)90386-5 · Cited by 417
Short, J. M., Wynshaw-Boris, A. J., Short, H. P., & Hanson, R. W. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67574-x · Cited by 385
Roberts, S., Ha, I., Maldonado, E., Reinberg, D., & Green, M. R. (1993) · Nature · doi:10.1038/363741a0 · Cited by 222
Self-citationHeyduk, T., & Lee, J. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1744 · Cited by 205
Dwarki, V., Montminy, M., & Verma, I. M. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08099.x · Cited by 198
The cAMP-regulated transcription factor CREB interactswith a component of the TFIID complex.
Ferreri, K., Gill, G., & Montminy, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1210 · Cited by 193
LeTilly, V., & Royer, C. A. (1993) · Biochemistry · doi:10.1021/bi00081a021 · Cited by 157
CAP interacts with RNA polymerase in solution in the absence of promoter DNA
Heyduk, T., Lee, J. C., Ebright, Y. W., Blatter, E. E., Zhou, Y., & Ebright, R. H. (1993) · Nature · doi:10.1038/364548a0 · Cited by 92
Engineered leucine zippers show that hemiphosphorylated CREB complexes are transcriptionally active.
Loriaux, M., Rehfuss, R. P., Brennan, R. G., & Goodman, R. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.9046 · Cited by 54
Self-citationBinding Constant Determination Studies Utilizing Recombinant ΔCREB Protein
Williams, J. S., Dixon, J. E., & ANDRISANI, O. M. (1993) · DNA and Cell Biology · doi:10.1089/dna.1993.12.183 · Cited by 21
Research works printed but not linked: 1
- Gonzalez, G. A. & Montminy, M. R. Cell 59, 675–680 (1989). · DOI
Cited by
Sorted by citations
Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism
Desvergne, B., & Wahli, W. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.5.0380 · Cited by 3,115
The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
Ogryzko, V. V., Schiltz, R. L., Russanova, V., Howard, B. H., & Nakatani, Y. (1996) · Cell · doi:10.1016/s0092-8674(00)82001-2 · Cited by 2,952
Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling
Hunter, T. R. (1995) · Cell · doi:10.1016/0092-8674(95)90405-0 · Cited by 2,961
Karin, M., Liu, Z.-G., & Zandi, E. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80068-3 · Cited by 2,904
Transcriptional regulation by the phosphorylation-dependent factor CREB
Mayr, B., & Montminy, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085068 · Cited by 2,587
Metadata
- Authors
- Kwok, R. P. S., Lundblad, J. R., Chrivia, J. C., Richards, J. P., Bächinger, H. P., Brennan, R. G., Roberts, S. G. E., Green, M. R., & Goodman, R. H.
- Affiliations
- Oregon Health & Science University (US)
- Venue
- Nature
- Published
- 1994-07
- Volume
- 370
- Issue
- 6486
- Pages
- 223-226
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1964337986
- Cited by
- 1,443
- References
- 19
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 15 · 2023: 10 · 2022: 16 · 2021: 15 · 2020: 15 · 2019: 7 · 2018: 18 · 2017: 21 · 2016: 22 · 2015: 13 · 2014: 21 · 2013: 29 · 2012: 36
- FWCI
- 30.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- CBP, CREB, transcriptional coactivator, transcriptional activation, protein kinase A phosphorylation, TFIIB, protein-protein interaction
- MeSH terms
- Animals, Base Sequence, Binding Sites, DNA, Enhancer Elements, Genetic, Fluorescence Polarization, Molecular Sequence Data, Nuclear Proteins, Phosphorylation, Protein Binding, Recombinant Fusion Proteins, Somatostatin, Transcription Factors, Transcription, Genetic, Tumor Cells, Cultured, Trans-Activators, Zinc Fingers, PC12 Cells, Cyclic AMP Response Element-Binding Protein, Transcription Factor TFIIB, CREB-Binding Protein, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
