Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1
Open accessAbstract
Metabotropic glutamate receptor 1 (mGluR1) is a member of a large family of G-protein-coupled glutamate receptors, the physiological functions of which are largely unknown. Mice deficient in mGluR1 have severe motor coordination and spatial learning deficits. They have no gross anatomical or basic electrophysiological abnormalities in either the cerebellum or hippocampus, but they show impaired cerebellar long-term depression and hippocampal mossy fibre long-term potentiation. mGluR1-deficient mice should therefore be valuable models for studying synaptic plasticity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The only exceptional case, the mGluR1 mutant mice, is complicated by the fact that two groups have generated and analyzed these mutants independently and have obtained opposing results.
“It is important to point out that the only exceptional case, namely that of the mGluR1 mutant mice, is complicated by the fact that two groups have generated and analyzed these mutants independently and have obtained opposing results (Aiba et al., 1994; Conquet et al., 1994; Chen and Tonegawa, 1997).”
From The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. (1996) · cites this paper as Conquet et al., 1994
Previous studies found a correlated impairment in Scc-CA1 LTP and spatial memory.
“These studies found a correlated impairment in Scc-CA1 LTP and spatial memory (but see Conquet et al., 1994).”
From The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. (1996) · cites this paper as Conquet et al., 1994
Cited by
Sorted by citations
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.
Tsien, J. Z., Huerta, P. T., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81827-9 · Cited by 1,782 · see citing works
Long-term depression in the CNS
Collingridge, G. L., Peineau, S., Howland, J. G., & Wang, Y. T. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2867 · Cited by 926 · see citing works
Self-citationTu, J. C., Xiao, B., Yuan, J. P., Lanahan, A. A., Leoffert, K., Li, M., Linden, D. J., & Worley, P. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80589-9 · Cited by 862 · see citing works
Kamiya, H., Shinozaki, H., & Yamamoto, C. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021395 · Cited by 327 · see citing works
Recovery from Polyglutamine-Induced Neurodegeneration in Conditional <i>SCA1</i> Transgenic Mice
Zu, T., Duvick, L. A., Kaytor, M. D., Berlinger, M. S., Zoghbi, H. Y., Clark, H. B., & Orr, H. T. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2978-04.2004 · Cited by 262 · see citing works
Altered long-term potentiation in the young and old Ts65Dn mouse, a model for down syndrome
Siarey, R. J., Stoll, J., Rapoport, S. I., & Galdzicki, Z. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00157-3 · Cited by 222 · see citing works
Nicotine regulates multiple synaptic proteins by inhibiting proteasomal activity
Rezvani, K., Teng, Y., Shim, D., & De Biasi, M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3353-07.2007 · Cited by 113 · see citing works
Lapointe, V., Morin, F., Ratté, S., Croce, A., Conquet, F., & Lacaille, J. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.053603 · Cited by 103 · see citing works
Self-citationDuvoisin, R. M., Zhang, C., Pfankuch, T. F., O'Connor, H., Gayet‐Primo, J., Quraishi, S., & Raber, J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04210.x · Cited by 102 · see citing works
- Authors
- Conquet, F., Bashir, Z. I., Davies, C. H., Daniel, H., Ferraguti, F., Bordi, F., Franz-Bacon, K., Reggiani, A., Matarese, V., Condé, F., Collingridge, G. L., & Crépel, F.
- Affiliations
- University of Bristol (GB)
- University of Birmingham (GB)
- Université Paris-Sud (FR)
- GlaxoSmithKline (Italy) (IT)
- Venue
- Nature
- Published
- 1994-11
- Volume
- 372
- Issue
- 6503
- Pages
- 237-243
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1996805443
- Cited by
- 743
- References
- 0
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 10 · 2022: 10 · 2021: 9 · 2020: 9 · 2019: 8 · 2018: 11 · 2017: 11 · 2016: 17 · 2015: 12 · 2014: 9 · 2013: 9 · 2012: 22
- FWCI
- 21.69
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- metabotropic glutamate receptor 1, motor coordination deficits, spatial learning deficits, synaptic plasticity, long-term depression, long-term potentiation, cerebellum, hippocampus
- MeSH terms
- Animals, Base Sequence, Cell Line, Cerebellum, Electrophysiology, Female, Hippocampus, Learning Disabilities, Mice, Inbred C57BL, Molecular Sequence Data, Motor Activity, Neuromuscular Diseases, Neuronal Plasticity, Oligodeoxyribonucleotides, Purkinje Cells, Synapses, Mutagenesis, Long-Term Potentiation, Receptors, Metabotropic Glutamate, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
