The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation
Open accessAbstract
ALTHOUGH phantom-limb pain is a frequent consequence of the amputation of an extremity, little is known about its origin1-4. On the basis of the demonstration of substantial plasticity of the somatosensory cortex after amputation5 or somatosensory deafferentation in adult monkeys6, it has been suggested that cortical reorganization could account for some non-painful phantom-limb phenomena in amputees and that cortical reorganization has an adaptive (that is, pain-preventing) function2,5,7,8. Theoretical and empirical work on chronic back pain9,10 has revealed a positive relationship between the amount of cortical alteration and the magnitude of pain, so we predicted that cortical reorganization and phantom-limb pain should be positively related. Using non-invasive neuromagnetic imaging techniques to determine cortical reorganization in humans11-13, we report a very strong direct relationship (r = 0.93) between the amount of cortical reorganization and the magnitude of phantom limb pain (but not non-painful phantom phenomena) experienced after arm amputation. These data indicate that phantom-limb pain is related to, and may be a consequence of, plastic changes in primary somatosensory cortex.
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Cites
The West Haven-Yale Multidimensional Pain Inventory (WHYMPI)
Kerns, R. D., Turk, D. C., & Rudy, T. E. (1985) · Pain · doi:10.1016/0304-3959(85)90004-1 · Cited by 2,128
Phantom limbs, the self and the brain: The D.O. Hebb memorial lecture
Melzack, R. (1989) · Canadian Psychology / Psychologie canadienne · doi:10.1037/h0079793 · Cited by 260
Cited by
The biopsychosocial approach to chronic pain: Scientific advances and future directions.
Gatchel, R. J., Peng, Y. B., Peters, M. L., Fuchs, P. N., & Turk, D. C. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.4.581 · Cited by 3,392
Human brain mechanisms of pain perception and regulation in health and disease
Apkarian, A. V., Bushnell, M. C., Treede, R., & Zubieta, J. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.11.001 · Cited by 3,126
Proske, U., & Gandevia, S. C. (2012) · Physiological Reviews · doi:10.1152/physrev.00048.2011 · Cited by 2,223
Baguley, D., McFerran, D., & Hall, D. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60142-7 · Cited by 1,245
Beneficial effects of physical exercise on neuroplasticity and cognition
Hötting, K., & Röder, B. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.005 · Cited by 991
Metadata
- Authors
- Flor, H., Elbert, T., Knecht, S., Wienbruch, C., Pantev, C., Birbaumers, N., Larbig, W., & Taub, E.
- Venue
- Nature
- Published
- 1995-06
- Volume
- 375
- Issue
- 6531
- Pages
- 482-484
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2037667533
- Cited by
- 1,845
- References
- 2
- FWCI
- 43.27
- Type
- journal article
- Language
- en
- Open access
- green
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- Flor, H., Elbert, T., Knecht, S., Wienbruch, C., Pantev, C., Birbaumers, N., Larbig, W., & Taub, E. (1995). Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation. Nature. https://doi.org/10.1038/375482a0
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