The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1
Abstract
The process of learning involves stable changes in synaptic efficacy for which long-term potentiation (LTP) provides a widely adopted mammalian model. Synaptic modification induced by learning or LTP may involve the action of cell adhesion molecules. One such candidate is the ubiquitous neuronal glycoprotein Thy-1. In mice in which the gene encoding Thy-1 has been inactivated, we find a regionally selective impairment of LTP in vivo in the hippocampal formation: LTP is normal in area CA1 but strongly inhibited in the dentate gyrus. Spatial learning by Thy-1-deficient mice, as assessed in the watermaze, is unimpaired. Thus LTP in the cortical input to the dentate gyrus seems not to be required for spatial learning.
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“first, theplasticity inthe EC-DGandDG-CA3 synapses seems to be dispensable (Huang et al., 1995; Nosten-Bertrand et al., 1996);”
From The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. (1996) · cites this paper as Nosten-Bertrand et al., 1996
In the citing paper
“By contrast, it has been shown that impairments of mossy fiber-CA3 LTP(Huang etal., 1995) and perforant path-dentate LTP (Nosten-Bertrand et al., 1996) are not correlated with spatial memory deficit.”
From The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. (1996) · cites this paper as Nosten-Bertrand et al., 1996
Citations
Cites
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Synaptic Plasticity and Memory: An Evaluation of the Hypothesis
Martin, S. J., Grimwood, P. D., & Morris, R. G. M. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.649 · Cited by 2,794
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Lynch, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00014.2003 · Cited by 2,074
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.
Tsien, J. Z., Huerta, P. T., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81827-9 · Cited by 1,782
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Essential Role for TrkB Receptors in Hippocampus-Mediated Learning
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Metadata
- Authors
- Nosten-Bertrand, M., Errington, M. L., Murphy, K. P. S. J., Tokugawa, Y., Barboni, E., Kozlova, E., Michalovich, D., Morris, R. G. M., Silver, J., Stewart, C. L., Bliss, T. V. P., & Morris, R. J.
- Affiliations
- National Institute for Medical Research (GB)
- Cornell University (US)
- Erasmus University Rotterdam (NL)
- Venue
- Nature
- Published
- 1996-02
- Volume
- 379
- Issue
- 6568
- Pages
- 826-829
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2089087278
- Cited by
- 232
- References
- 29
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 2 · 2013: 6 · 2012: 7
- FWCI
- 10.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- CD90, long-term potentiation, spatial learning, hippocampus, dentate gyrus, CA1, adhesion molecules, synaptic plasticity, knockout mice, water maze
- MeSH terms
- Animals, Female, gamma-Aminobutyric Acid, Hippocampus, Male, Mice, Inbred C57BL, Long-Term Potentiation, Gene Targeting, Maze Learning, Thy-1 Antigens, Dentate Gyrus, Mice
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