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Biochemical evidence that Patched is the Hedgehog receptor
Open accessAbstract
THE protein Sonic hedgehog (Shh) is essential for a variety of patterning events during development. It is the signal from the notochord that induces ventral cell fate in the neural tube and somites1,2, and is the polarizing signal for patterning of the anterior–posterior axis of the developing limb bud3. Because of these and other inductive functions of Shh, it is important to understand how the Hedgehog (Hh) signal is received by the target cells. Here we describe binding studies using labelled Shh that strongly suggest that the Hh receptor is encoded by patched (ptc), a gene first identified in genetic screens in Drosophila4.
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Citations
Cited by
Wnt signaling: a common theme in animal development
Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696
1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Self-citationSasaki, H., Nishizaki, Y., Hui, C.-C., Nakafuku, M., & Kondoh, H. (1999) · Development · doi:10.1242/dev.126.17.3915 · Cited by 715
Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
Bai, C. B., Auerbach, W., Lee, J. S., Stephen, D., & Joyner, A. L. (2002) · Development · doi:10.1242/dev.129.20.4753 · Cited by 692
Metadata
- Authors
- Marigo, V., Davey, R. A., Zuo, Y., Cunningham, J. M., & Tabin, C. J.
- Venue
- Nature
- Published
- 1996-11
- Volume
- 384
- Issue
- 6605
- Pages
- 176-179
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2056994384
- Cited by
- 858
- References
- 0
- FWCI
- 18.80
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Biochemical evidence that Patched is the Hedgehog receptor. https://app.cochat.ai/papers/10.1038/384176a0
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- Marigo, V., Davey, R. A., Zuo, Y., Cunningham, J. M., & Tabin, C. J. (1996). Biochemical evidence that Patched is the Hedgehog receptor. Nature. https://doi.org/10.1038/384176a0
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