20S cyclosome complex formation and proteolytic activity inhibited by the cAMP/PKA pathway

Antibodies, a laboratory manual

(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318

[12] One-step gene disruption in yeast

Rothstein, R. J. (1983) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(83)01015-0 · Cited by 3,282

A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

King, R. W., Peters, J., Tugendreich, S., Rolfe, M., Hieter, P., & Kirschner, M. W. (1995) · Cell · doi:10.1016/0092-8674(95)90338-0 · Cited by 956

nmt1 of fission yeast. A highly transcribed gene completely repressed by thiamine.

Maundrell, K. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38525-4 · Cited by 841

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

Sudakin, V., Ganoth, D., Dahan, A., Heller, H., Hershko, J., Luca, F. C., RUDERMAN, J. V., & Hershko, A. (1995) · Molecular Biology of the Cell · doi:10.1091/mbc.6.2.185 · Cited by 752

Genes involved in sister chromatid separation are needed for b-type cyclin proteolysis in budding yeast

Irniger, S., Piatti, S., Michaelis, C., & Nasmyth, K. (1995) · Cell · doi:10.1016/0092-8674(95)90337-2 · Cited by 560

Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast.

Funabiki, H., Hagan, I., Uzawa, S., & Yanagida, M. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.121.5.961 · Cited by 516

Ubiquitin‐conjugating enzymes UBC4 and UBC5 mediate selective degradation of short‐lived and abnormal proteins.

Seufert, W., & Jentsch, S. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08141.x · Cited by 500

Cut2 proteolysis required for sister-chromatid separation in fission yeast

Funabiki, H., Yamano, H., Kumada, K., Nagao, K., Hunt, T., & Yanagida, M. (1996) · Nature · doi:10.1038/381438a0 · Cited by 453

CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition

Tugendreich, S., Tomkiel, J. E., Earnshaw, W. C., & Hieter, P. (1995) · Cell · doi:10.1016/0092-8674(95)90336-4 · Cited by 364

Synergistic inhibition of APC/C by glucose and activated Ras proteins can be mediated by each of the Tpk1–3 proteins in Saccharomyces cerevisiae

Bolte, M., Dieckhoff, P., Krause, C., Braus, G. H., & Irniger, S. (2003) · Microbiology · doi:10.1099/mic.0.26062-0 · Cited by 27

High dosage expression of a zinc finger protein, Grt1, suppresses a mutant of fission yeast slp1+, a homolog of CDC20/p55CDC/Fizzy

Yamada, H. Y., Matsumoto, S., & Matsumoto, T. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.22.3989 · Cited by 26

Posttranscriptional Control of Gene Expression in Filamentous Fungi

Sachs, M. S. (1998) · Fungal Genetics and Biology · doi:10.1006/fgbi.1998.1041 · Cited by 24

Functional analysis of the Saccharomyces cerevisiae UBC11 gene

Townsley, F. M., & RUDERMAN, J. V. (1998) · Yeast · doi:10.1002/(sici)1097-0061(19980615)14:8 · Cited by 24

BIMAAPC3, a component of the Aspergillus anaphase promoting complex/cyclosome, is required for a G2 checkpoint blocking entry into mitosis in the absence of NIMA function

Lies, C. M., Cheng, J., James, S. W., Morris, N. R., O’Connell, M. J., & Mirabito, P. M. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.10.1453 · Cited by 21

The budding yeast cohesin gene SCC1/MCD1/RHC21 genetically interacts with PKA, CDK and APC

Heo, S., Tatebayashi, K., & Ikeda, H. (1999) · Current Genetics · doi:10.1007/s002940050507 · Cited by 20

Activating the Anaphase Promoting Complex to Enhance Genomic Stability and Prolong Lifespan

Harkness, T. A. A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071888 · Cited by 22

Ibd1p, a possible spindle pole body associated protein, regulates nuclear division and bud separation in Saccharomyces cerevisiae

Lee, J., Hwang, H.-S., Kim, J., & Song, K. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(99)00015-4 · Cited by 19

Analysis of the Schizosaccharomyces pombe Cell CyclePreprint

Hagan, I., Grallert, Á., & Simanis, V. (2016) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top082800 · Cited by 20

Genomic expression patterns in cell separation mutants of Schizosaccharomyces pombe defective in the genes sep10 + and sep15 + coding for the Mediator subunits Med31 and Med8

Miklós, I., Szilagyi, Z., Watt, S., Zilahi, E., Batta, G., Antunovics, Z., Enczi, K., Bähler, J., & Sipiczki, M. (2007) · Molecular Genetics and Genomics · doi:10.1007/s00438-007-0296-z · Cited by 18

Temporal proteome profiling of taxol‐induced mitotic arrest and apoptosis

Bull, V. H., Fargestad, E. M., Strozynski, M., & Thiede, B. (2010) · Electrophoresis · doi:10.1002/elps.200900780 · Cited by 18

Is the yeast Anaphase Promoting Complex needed to prevent re‐replication during G2 and M phases?

Pichler, S., Piatti, S., & Nasmyth, K. (1997) · The EMBO Journal · doi:10.1093/emboj/16.19.5988 · Cited by 18

Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin

Kimata, Y., Matsuyama, A., Nagao, K., Furuya, K., Obuse, C., Yoshida, M., & Yanagida, M. (2008) · Journal of Cell Science · doi:10.1242/jcs.024224 · Cited by 17

Proteolysis and Tyrosine Phosphorylation of p34 /Cyclin B

Ye, X. S., Fincher, R. R., Tang, A., McNeal, K. K., Gygax, S. E., Wexler, A. N., Ryan, K. B., James, S. W., & Osmani, S. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.33384 · Cited by 16

Histone H2B Ubiquitination Promotes the Function of the Anaphase-Promoting Complex/Cyclosome inSchizosaccharomyces pombe

Elmore, Z. C., Beckley, J. R., Chen, J., & Gould, K. L. (2014) · G3 Genes Genomes Genetics · doi:10.1534/g3.114.012625 · Cited by 15

Two distinct ubiquitin-proteolysis pathways in the fission yeast cell cycle

Toda, T., Ochotorena, I., & Kominami, K. (1999) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1999.0498 · Cited by 14

The control of mitosis

Mary, L. H. (2000) · Frontiers in bioscience · doi:10.2741/hixon · Cited by 14

The phenomenon of lipid metabolism “cut” mutants

Zach, R., & Převorovský, M. (2018) · Yeast · doi:10.1002/yea.3358 · Cited by 14

Interaction of APC/C-E3 Ligase with Swi6/HP1 and Clr4/Suv39 in Heterochromatin Assembly in Fission Yeast

Dubey, R. N., Nakwal, N., Bisht, K. K., Saini, A., Haldar, S., & Singh, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806461200 · Cited by 12

CSL protein regulates transcription of genes required to prevent catastrophic mitosis in fission yeast

Převorovský, M., Oravcová, M., Zach, R., Marešová, A., Bähler, J., Půta, F., & Folk, P. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1235100 · Cited by 12

Regulation of p34cdc2/cylinB H1 and NIMA kinases during the G2/M transition and checkpoint responses in Aspergillus nidulans

Ye, X. S., & Osmani, S. A. (1997) · Springer eBooks · doi:10.1007/978-1-4615-5371-7_17 · Cited by 12

A Screen for Genes Involved in the Anaphase Proteolytic Pathway Identifies tsm1+, a Novel Schizosaccharomyces pombe Gene Important for Microtubule Integrity

Grishchuk, E. L., Howe, J. L., & McIntosh, J. R. (1998) · Genetics · doi:10.1093/genetics/149.3.1251 · Cited by 12

An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeast

Horikoshi, Y., Habu, T., & Matsumoto, T. (2013) · Cell Cycle · doi:10.4161/cc.23946 · Cited by 11

Mitotic defects in fission yeast lipid metabolism ‘cut’ mutants are suppressed by ammonium chloride

Zach, R., Princová, J., Schätz, M., Ťupa, O., Grallert, B., & Převorovský, M. (2018) · FEMS Yeast Research · doi:10.1093/femsyr/foy064 · Cited by 11

Hyphal differentiation induced via a DNA damage checkpoint-dependent pathway engaged in crosstalk with nutrient stress signaling in Schizosaccharomyces japonicus

Furuya, K., & Niki, H. (2012) · Current Genetics · doi:10.1007/s00294-012-0384-4 · Cited by 11

Chromosome segregation in fission yeast with mutations in the tubulin folding cofactor D

Fedyanina, O. S., Mardanov, P. V., Tokareva, E. M., McIntosh, J. R., & Grishchuk, E. L. (2006) · Current Genetics · doi:10.1007/s00294-006-0095-9 · Cited by 11

Molecular cloning of cDNA encoding a cyclin‐selective ubiquitin carrier protein (E2‐C) from Carassius auratus (goldfish) and expression analysis of the cloned gene

Tokumoto, M., Nagahama, Y., & Tokumoto, T. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01189-8 · Cited by 11

Mal3 is a multi-copy suppressor of the sensitivity to microtubule-depolymerizing drugs and chromosome mis-segregation in a fission yeast pka1 mutant

Tanabe, T., Yamaga, M., Kawamukai, M., & Matsuo, Y. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214803 · Cited by 10

Glucose limitation andpka1deletion rescue aberrant mitotic spindle formation induced by Mal3 overexpression inSchizosaccharomyces pombe

Tanabe, T., Kawamukai, M., & Matsuo, Y. (2020) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2020.1763157 · Cited by 10

Glucose Signaling Is Connected to Chromosome Segregation Through Protein Kinase A Phosphorylation of the Dam1 Kinetochore Subunit inSaccharomyces cerevisiae

Shah, S. B., Parmiter, D., Constantine, C., Elizalde, P., Naldrett, M. J., Karpova, T., & Choy, J. S. (2018) · Genetics · doi:10.1534/genetics.118.301727 · Cited by 10

Cyclic AMP Delays G2 Progression and Prevents Efficient Accumulation of Cyclin B1 Proteins in Mouse Macrophage Cells.

Kurokawa, K., & Kato, J. (1998) · Cell Structure and Function · doi:10.1247/csf.23.357 · Cited by 10

Suppression of a mitotic mutant by tRNA-Ala anticodon mutations that produce a dominant defect in late mitosis

Kimata, Y., & Yanagida, M. (2004) · Journal of Cell Science · doi:10.1242/jcs.01078 · Cited by 10

A brute force postgenome approach to identify temperature‐sensitive mutations that negatively interact with separase and securin plasmids

Matsumura, T., Yuasa, T., Hayashi, T., Obara, T., Kimata, Y., & Yanagida, M. (2003) · Genes to Cells · doi:10.1046/j.1365-2443.2003.00637.x · Cited by 10

Cell cycle checkpoint control

Murakami, H., & Okayama, H. (1997) · Experimental & Molecular Medicine · doi:10.1038/emm.1997.1 · Cited by 8

Co-activator independent differences in how the metaphase and anaphase APC/C recognise the same substrate

Matsusaka, T., Enquist-Newman, M., Morgan, D. O., & Pines, J. (2014) · Biology Open · doi:10.1242/bio.20149415 · Cited by 7

Molecular cloning of cDNA encoding a ubiquitin-activating enzyme (E1) from goldfish (Carassius auratus) and expression analysis of the cloned gene

Tokumoto, M., Nagahama, Y., & Tokumoto, T. (2000) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00091-9 · Cited by 7

Regulation of the Cell Cycle by the Ubiquitin Pathway

Slingerland, J. M., & Pagano, M. (1998) · Results and problems in cell differentiation · doi:10.1007/978-3-540-69686-5_6 · Cited by 7

Impact of repeated in-vitro bacterial culture on virulence and antibiotic resistance characteristics: a study of Gram-positive and Gram-negative fish pathogens

Bag, A., Kumar, V., Adhikari, A., Mandal, B., Dhar, S., & Das, B. K. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1601681 · Cited by 6

Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe

Siváková, B., Wagner, A., Kretová, M., Jakubı́ková, J., Gregáň, J., Kratochwill, K., Baráth, P., & Čipák, L. (2024) · Scientific Reports · doi:10.1038/s41598-024-74523-0 · Cited by 6

A phosphorylation site mutant of Schizosaccharomyces pombe cdc2p fails to promote the metaphase to anaphase transition

Gould, K. L., Feoktistova, A., & Fleig, U. N. (1998) · Molecular and General Genetics MGG · doi:10.1007/s004380050834 · Cited by 6

Uncoupling of Mitosis and Cytokinesis Upon a Prolonged Arrest in Metaphase Is Influenced by Protein Phosphatases and Mitotic Transcription in Fission Yeast

Chica, N., Portantier, M., Nyquist-Andersen, M., Burriel, S. E., & López‐Avilés, S. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.876810 · Cited by 5

A role for the carbon source of the cell and protein kinase A in regulating the S. pombe septation initiation network

Özdemir, Ö. U., Krapp, A., Mangeat, B., Spaltenstein, M., & Simanis, V. (2024) · Journal of Cell Science · doi:10.1242/jcs.261488 · Cited by 4

[SNG2], a prion form of Cut4/Apc1, confers non-Mendelian inheritance of heterochromatin silencing defect in fission yeast

Sharma, S., Srivastava, S., Dubey, R. N., Mishra, P., & Singh, J. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae1136 · Cited by 4

PKIB, a Novel Target for Cancer Therapy

Musket, A., Moorman, J. P., Zhang, J., & Jiang, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094664 · Cited by 3

Erratum to: Controlling the response to DNA damage by the APC/C-Cdh1

de Boer, H. R., Llobet, S. G., & van Vugt, M. A. T. M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2279-x · Cited by 3

Regulation of mitosis : molecular analysis of the anaphase-promoting complex

Jörgensen, P.-M. (2000) · Figshare · Cited by 2

Cyclin B1 turnover and the mechanism causing insensitivity of fully grown mouse oocytes to cycloheximide inhibition of meiotic resumption

Han, D. S., Liu, X., Jiao, G.-Z., Liang, B., He, N., Gao, W.-Q., & Tan, J. (2012) · Theriogenology · doi:10.1016/j.theriogenology.2012.01.008 · Cited by 1

Decondensation ofXenopussperm chromatin usingSaccharomyces cerevisiaewhole-cell extractsThis paper is one of a selection of papers published in this Special Issue, entitled The Nucleus: A Cell Within A Cell.

Harkness, T. A. A. (2006) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y05-042 · Cited by 1

Chromosome Cohesion and Segregation

Takahashi, K., & Yanagida, M. (2004) · Springer eBooks · doi:10.1007/978-3-662-10360-9_11 · Cited by 1

Regulation of the anaphase promoting complex (APC/C) in the mitotic and meiotic cell cycle of Saccharomyces cerevisiae

Bolte, M. (2004) · doi:10.53846/goediss-3456 · Cited by 1

An analysis of Apc5p/Fob1p interactions in yeast : implications for extended lifespan

Chen, J. C. (2006) · University Library - University of Saskatchewan (University of Saskatchewan)

Yukiko Yamashita: The centrosomes get there first

Sedwick, C. E. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.2016pi

Funktionelle Analyse des Regulatorproteins ICP0 von Herpes Simplex Virus Typ 2

Albrecht, N. (2006)

Associate Editor: D. Shugar The 90-kDa Molecular Chaperone Family: Structure, Function, and Clinical Applications. A Comprehensive Review

Csermely, P., Schnaider, T., Prohászka, Z., & Nardai, G. (1998)

Papel da proteína prion celular e seu ligante, stip1, na neurogênese adulta.

da Silva, C. M. C. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2016.tde-11082016-145839

Aspergillus Bibliography

Clutterbuck, J. (1997) · Fungal Genetics Reports · doi:10.4148/1941-4765.1294

One stop mycology

Frazer, L. N. (1997) · Mycological Research · doi:10.1017/s0953756297004462

mGem: Cut4/Apc1 and its prion form at the cross roads of cell cycle regulation, heterochromatin organization, RNAi, stress response, and evolution

Sharma, S. B., & Singh, J. (2026) · mBio · doi:10.1128/mbio.00837-25

Analysis of genetic interaction between the cAMP/PKA pathway and the EB1 family protein Mal3 in Schizosaccharomyces pombe

卓磨, 田., Tanabe, T., Tanabe, T., & 39897 (2020) · Institutional Repositories DataBase (IRDB)

Discovery of a small peptide that increases yeast lifespan by enhancing the function of APCCdh1 in nondividing quiescent cells

Harris, R. E., Postnikoff, S. D. L., Shukla, N. K., Harkness, A., Brooks, H. M., Khawaja, A.-A.-W., Malo, M. E., Verdugo, C. Z., Waddell, B. M., Wu, C., et al. (2026) · Genetics · doi:10.1093/genetics/iyag249

Genetic analysis of the genes involved in mitosis in fission yeast Schizosaccharomyces pombe

Nakaseko, Y., & Yanagida, M. (2002) · Progress in biotechnology · doi:10.1016/s0921-0423(02)80046-6

Distinct subunit functions and cell cycle regulated phosphorylation of 20S APC/cyclosome required for anaphase in fission yeast

Yamada, H. Y., Kumada, K., & Yanagida, M. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.15.1793 · Cited by 131

Control of metaphase–anaphase progression by proteolysis: cyclosome function regulated by the protein kinase A pathway, ubiquitination and localization

Yanagida, M., Yamashita, Y. M., Tatebe, H., Ishii, K., Kumada, K., & Nakaseko, Y. (1999) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1999.0499 · Cited by 51

Fission yeast APC/cyclosome subunits, Cut20/Apc4 and Cut23/Apc8, in regulating metaphase‐anaphase progression and cellular stress responses

Yamashita, Y. M., Nakaseko, Y., Kumada, K., Nakagawa, T., & Yanagida, M. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00274.x · Cited by 38

Phosphorylation of the Cyclosome Is Required for Its Stimulation by Fizzy/cdc20

Shteinberg, M., Protopopov, Y., Listovsky, T., Brandeis, M., & Hershko, A. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0884 · Cited by 132

PKA and MPF-Activated Polo-like Kinase Regulate Anaphase-Promoting Complex Activity and Mitosis Progression

Kotani, S., Tugendreich, S., Fujii, M., Jorgensen, P.-M., Watanabe, N., Höög, C., Hieter, P., & Todokoro, K. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80037-4 · Cited by 301