Neurturin, a relative of glial-cell-line-derived neurotrophic factor
Abstract
The normal development of the vertebrate nervous system entails the death of 30-70% of the neurons originally generated in most neuronal populations. This naturally occurring cell death is regulated by specific neurotrophic factors that promote neuronal survival and which are produced in limiting quantities by target cells, glial cells and neurons. These factors are also of potential utility as therapeutic agents for neurodegenerative diseases. Here we describe the purification and cloning of a new neurotrophic factor, identified on the basis of its ability to support the survival of sympathetic neurons in culture. This factor, neurturin, is structurally related to glial-cell-line-derived neurotrophic factor (GDNF). These factors can each activate the MAP kinase signalling pathway in cultured sympathetic neurons and support the survival of sympathetic neurons, as well as of sensory neurons of the nodose and dorsal root ganglia. Thus, neurturin and GDNF together now define a new family of neurotrophic factors.
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NRTN is a member of the glial cell-line derived neurotrophic factor family which promotes neuronal survival.
“NRTN is a member of the glial cell-line derived neurotrophic factor family which promotes neuronal survival [59].”
From CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the treatment of Alzheimer's disease (2026) · cites this paper as [59]
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- Authors
- Kotzbauer, P. T., Lampe, P. A., Heuckeroth, R. O., Golden, J. P., Creedon, D. J., Johnson Jr, E. M., & Milbrandt, J.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- Nature
- Published
- 1996-12
- Volume
- 384
- Issue
- 6608
- Pages
- 467-470
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2087262420
- Cited by
- 710
- References
- 0
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 15 · 2020: 11 · 2019: 13 · 2018: 4 · 2017: 12 · 2016: 14 · 2015: 14 · 2014: 5 · 2013: 19 · 2012: 22
- FWCI
- 22.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- neurturin, glial cell line-derived neurotrophic factor, neurotrophic factors, MAPK signaling, sensory neurons, dorsal root ganglia, neurodegenerative diseases, neuronal apoptosis
- MeSH terms
- Amino Acid Sequence, Animals, Cell Survival, Cells, Cultured, Chromatography, Affinity, Cloning, Molecular, Enzyme Activation, Ganglia, Spinal, Cricetinae, Humans, Molecular Sequence Data, Nerve Growth Factors, Nerve Tissue Proteins, Neuroglia, Neurons, Nodose Ganglion, CHO Cells, 3T3 Cells, Culture Media, Conditioned, Rats, Sprague-Dawley, Sequence Homology, Amino Acid, Superior Cervical Ganglion, Calcium-Calmodulin-Dependent Protein Kinases, DNA, Complementary, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase 3, Glial Cell Line-Derived Neurotrophic Factor, Neurturin, Mice, Rats
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