Cited by 472Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

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A role for Cajal–Retzius cells and reelin in the development of hippocampal connections

Del Río, José A., Heimrich, Bernd, Borrell, Víctor, Förster, Eckart, Drakew, Alexander, Alcántara, Soledad, Nakajima, Kazunori, Miyata, Takaki, Ogawa, Masaharu, Mikoshiba, Katsuhiko, Derer, Paul, Frotscher, Michael, Soriano, Eduardo·1997·Nature

DOI 10.1038/385070a0

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Abstract

During development of the nervous system, specific recognition molecules provide the cues necessary for the formation of neural connections. In some regions, guiding cues for axonal pathfinding and target selection are provided by specific cells that exist only transiently during development, such as the floorplate or the cortical subplate. In the hippocampus, distinct groups of fibres innervate different layers. We have tested the hypothesis that transient neurons in the hippocampus provide positional information for the targeting of these fibres. Here we report that ablation of Cajal-Retzius cells in organotypic slice cultures of hippocampus prevented the ingrowth of entorhinal but not of commissural afferents. Experiments inhibiting Reelin (an extracellular matrix protein expressed by Cajal-Retzius cells) and analysis of reeler mutant mice showed dramatic abnormalities in the development of entorhinal afferents. Thus Cajal-Retzius cells and reelin are essential for the formation of layer-specific hippocampal connections.

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Authors: Del Río, J. A., Heimrich, B., Borrell, V., Förster, E., Drakew, A., Alcántara, S., Nakajima, K., Miyata, T., Ogawa, M., Mikoshiba, K., Derer, P., Frotscher, M., & Soriano, E.
Affiliations: University of Freiburg (DE)
Universitat de Barcelona (ES)
RIKEN (JP)
Kochi Medical School Hospital (JP)
Université Pierre-et-Marie-Curie (FR)
ORCID: Alcántara, Soledad
Nakajima, Kazunori
Miyata, Takaki
Mikoshiba, Katsuhiko
Frotscher, Michael
Soriano, Eduardo
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1997-01
Volume: 385
Issue: 6611
Pages: 70-74
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/385070a0
OpenAlex: W2070651871
Cited by: 472
References: 26
Citations by year: 2026: 4 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 13 · 2021: 8 · 2020: 11 · 2019: 6 · 2018: 10 · 2017: 11 · 2016: 17 · 2015: 12 · 2014: 16 · 2013: 14 · 2012: 11
FWCI: 14.31
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: Cajal-Retzius cells, reelin, hippocampus, axon guidance, reeler mutant mice, organotypic slice cultures, extracellular matrix
MeSH terms: Reelin Protein, Animals, Antibodies, Monoclonal, Astrocytes, Axons, Hippocampus, Mice, Neurologic Mutants, Nerve Tissue Proteins, Neural Pathways, Neurons, Afferent, Serine Endopeptidases, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, Entorhinal Cortex, Culture Techniques, Mice

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A role for Cajal–Retzius cells and reelin in the development of hippocampal connections

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