The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Transcriptional activation by recruitment
Abstract
The recruitment model for gene activation stipulates that an activator works by bringing the transcriptional machinery to the DNA. Recent experiments in bacteria and yeast indicate that many genes can be activated by this mechanism. These findings have implications for our understanding of the nature of activating regions and their targets, and for the role of histones in gene regulation.
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“Expression levels of all human genes were provided using RNA-seq data from ENCODE. This can be used to model the presence of cofactor proteins that can recruit TFs for binding (Ptashne and Gann, 1997).”
From WILDS: A Benchmark of in-the-Wild Distribution Shifts (2020) · cites this paper as Ptashne and Gann, 1997
Citations
Cites
How eukaryotic transcriptional activators work
Ptashne, M. (1988) · Nature · doi:10.1038/335683a0 · Cited by 1,828
Self-citationMECHANISM AND CONTROL OF TRANSCRIPTION INITIATION IN PROKARYOTES
McClure, W. R. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.001131 · Cited by 1,014
Mechanism of transcriptional activation by Sp1: Evidence for coactivators
Pugh, B. F., & Tjian, R. (1990) · Cell · doi:10.1016/0092-8674(90)90683-6 · Cited by 978
Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of Yeast
Hope, I. A., & Struhl, K. (1986) · Cell · doi:10.1016/0092-8674(86)90070-x · Cited by 918
Deletion analysis of GAL4 defines two transcriptional activating segments
Ma, J., & Ptashne, M. (1987) · Cell · doi:10.1016/0092-8674(87)90081-x · Cited by 887
Self-citationA Third Recognition Element in Bacterial Promoters: DNA Binding by the α Subunit of RNA Polymerase
Ross, W., Gosink, K. K., Salomon, J., Igarashi, K., Zou, C., Ishihama, A., Severinov, K., & Gourse, R. L. (1993) · Science · doi:10.1126/science.8248780 · Cited by 789
BIOCHEMISTRY AND STRUCTURAL BIOLOGY OF TRANSCRIPTION FACTOR IID (TFIID)
Burley, S. K., & Roeder, R. G. (1996) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.65.070196.004005 · Cited by 734
RSC, an Essential, Abundant Chromatin-Remodeling Complex
Cairns, B. R., Lorch, Y., Li, Y., Zhang, M., Lacomis, L., Erdjument‐Bromage, H., Tempst, P., Du, J., Laurent, B. C., & Kornberg, R. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81820-6 · Cited by 667
Polach, K. J., & Widom, J. (1995) · Journal of Molecular Biology · doi:10.1006/jmbi.1995.0606 · Cited by 657
Negative effect of the transcriptional activator GAL4
Gill, G., & Ptashne, M. (1988) · Nature · doi:10.1038/334721a0 · Cited by 648
Self-citation
Research works printed but not linked: 2
- Ptashne, M. A Genetic Switch: Phage Lambda and Higher Organisms (Cell and Blackwell Scientific, Cambridge, MA, 1992).
- Hawley, D. K. & McClure, W. R. Mechanism of activation of transcription initiation from the lambda-PRM promoter. J. Mol. Biol. 157, 493–525 (1982). · DOI
Cited by
Sorted by citations
Histone acetylation in chromatin structure and transcription
Grunstein, M. (1997) · Nature · doi:10.1038/38664 · Cited by 2,884
Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain
Gu, W., & Roeder, R. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80521-8 · Cited by 2,559
Histone acetylation and transcriptional regulatory mechanisms
Struhl, K. (1998) · Genes & Development · doi:10.1101/gad.12.5.599 · Cited by 1,815
Genome-Wide Location and Function of DNA Binding Proteins
Ren, B., Robert, F., Wyrick, J. J., Aparicio, O. M., Jennings, E. G., Simon, I., Zeitlinger, J., Schreiber, J., Hannett, N. M., Kanin, E. I., et al. (2000) · Science · doi:10.1126/science.290.5500.2306 · Cited by 1,768
Dissecting the regulatory circuitry of a eukaryotic genome
Holstege, F. C. P., Jennings, E. G., Wyrick, J. J., Lee, T. I., Hengartner, C. J., Green, M. R., Golub, T. R., Lander, E. S., & Young, R. A. (1998) · Cell · doi:10.1016/s0092-8674(00)81641-4 · Cited by 1,670
Metadata
- Authors
- Ptashne, M., & Gann, A.
- Affiliations
- Harvard University (US)
- Lancaster University (GB)
- Venue
- Nature
- Published
- 1997-04
- Volume
- 386
- Issue
- 6625
- Pages
- 569-577
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2087950896
- Cited by
- 1,158
- References
- 103
- Citations by year
- 2026: 5 · 2025: 20 · 2024: 29 · 2023: 13 · 2022: 22 · 2021: 32 · 2020: 20 · 2019: 22 · 2018: 21 · 2017: 15 · 2016: 34 · 2015: 18 · 2014: 35 · 2013: 27 · 2012: 43
- FWCI
- 8.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- transcriptional activation, recruitment model, activators, transcription machinery, histones, gene expression regulation, bacterial transcription
- MeSH terms
- Transcriptional Activation, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Fungal
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