Cited by 1,158Genomics and Chromatin DynamicsBacterial Genetics and BiotechnologyGene Regulatory Network Analysis

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Transcriptional activation by recruitment

Ptashne, Mark, Gann, Alexander·1997·Nature

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Abstract

The recruitment model for gene activation stipulates that an activator works by bringing the transcriptional machinery to the DNA. Recent experiments in bacteria and yeast indicate that many genes can be activated by this mechanism. These findings have implications for our understanding of the nature of activating regions and their targets, and for the role of histones in gene regulation.

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Authors: Ptashne, M., & Gann, A.
Affiliations: Harvard University (US)
Lancaster University (GB)
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1997-04
Volume: 386
Issue: 6625
Pages: 569-577
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/386569a0
OpenAlex: W2087950896
Cited by: 1,158
References: 103
Citations by year: 2026: 5 · 2025: 20 · 2024: 29 · 2023: 13 · 2022: 22 · 2021: 32 · 2020: 20 · 2019: 22 · 2018: 21 · 2017: 15 · 2016: 34 · 2015: 18 · 2014: 35 · 2013: 27 · 2012: 43
FWCI: 8.60
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Keywords: transcriptional activation, recruitment model, activators, transcription machinery, histones, gene expression regulation, bacterial transcription
MeSH terms: Transcriptional Activation, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Fungal

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