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Adaptive protein evolution in Drosophila
Open accessAbstract
For over 30 years a central question in molecular evolution has been whether natural selection plays a substantial role in evolution at the DNA sequence level. Evidence has accumulated over the last decade that adaptive evolution does occur at the protein level, but it has remained unclear how prevalent adaptive evolution is. Here we present a simple method by which the number of adaptive substitutions can be estimated and apply it to data from Drosophila simulans and D. yakuba. We estimate that 45% of all amino-acid substitutions have been fixed by natural selection, and that on average one adaptive substitution occurs every 45 years in these species.
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Citations
Cites
The hitch-hiking effect of a favourable gene
Smith, J. M., & Haigh, J. (1974) · Genetical Research · doi:10.1017/s0016672300014634 · Cited by 3,415
Cited by
Evolution of genes and genomes on the Drosophila phylogeny
Drosophila 12 Genomes Consortium (2007) · Nature · doi:10.1038/nature06341 · Cited by 2,010
Molecular Signatures of Natural Selection
Nielsen, R. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.073003.112420 · Cited by 1,641
Natural selection on protein-coding genes in the human genome
Bustamante, C. D., Fledel-Alon, A., Williamson, S., Nielsen, R., Todd Hubisz, M., Glanowski, S., Tanenbaum, D. M., White, T. J., Sninsky, J. J., Hernandez, R. D., et al. (2005) · Nature · doi:10.1038/nature04240 · Cited by 788
Genome sequencing and population genomics in non-model organisms
Ellegren, H. (2014) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2013.09.008 · Cited by 759
Detecting Natural Selection in Genomic Data
Vitti, J. J., Grossman, S. R., & Sabeti, P. C. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133526 · Cited by 694
Metadata
- Authors
- Smith, N. G. C., & Eyre-Walker, A.
- Venue
- Nature
- Published
- 2002-02
- Volume
- 415
- Issue
- 6875
- Pages
- 1022-1024
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2071537172
- Cited by
- 666
- References
- 1
- FWCI
- 14.51
- Type
- journal article
- Language
- en
- Open access
- green
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