The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Brain asymmetry and long-term memory
Abstract
The asymmetrical positioning of neural structures on the left or right side of the brain in vertebrates and in invertebrates may be correlated with brain laterality, which is associated with cognitive skills. But until now this has not been illustrated experimentally. Here we describe an asymmetrically positioned brain structure in the fruitfly Drosophila and find that the small proportion of wild-type flies that have symmetrical brains with two such structures lack a normal long-term memory, although their short-term memory is intact. Our results indicate that brain asymmetry may be required for generating or retrieving long-term memory.
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“In the fly brain, the asymmetric body is reproducibly around 4 times larger on the right hemisphere than on the left112–114, except in rare cases of situs inversus114,115.”
From Whole-brain annotation and multi-connectome cell typing of Drosophila (2024) · cites this paper as [112]
Citations
Cites
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Localization of Long-Term Memory Within the Drosophila Mushroom Body
Pascual, A., & Préat, T. (2001) · Science · doi:10.1126/science.1064200 · Cited by 368
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Left–right asymmetry in the nervous system: the Caenorhabditis elegans model
Hobert, O., Johnston, R. J., & Chang, S. S. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn897 · Cited by 165
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Sorted by citations
A GAL4-Driver Line Resource for Drosophila Neurobiology
Jenett, A., Rubin, G. M., Ngo, T.-T. B., Shepherd, D., Murphy, C., Dionne, H., Pfeiffer, B. D., Cavallaro, A., Hall, D., Jeter, J., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.09.011 · Cited by 1,449
A connectome and analysis of the adult Drosophila central brain
Scheffer, L. K., Xu, C. S., Januszewski, M., Lu, Z., Takemura, S.-Y., Hayworth, K. J., Huang, G. B., Shinomiya, K., Maitlin-Shepard, J., Berg, S., et al. (2020) · eLife · doi:10.7554/elife.57443 · Cited by 1,128
“The AB has been described as a fasciculin II (fasII)-positive structure that exhibits left-right structural asymmetry by Pascual et al.(Pascual et al., 2004), who reported that most flies have their AB only in the right hemisphere, while a small proportion (7.6”
BackgroundInfluentialsurvival with an asymmetrical brain: advantages and disadvantages of cerebral lateralization
Vallortígara, G., & Rogers, L. J. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000105 · Cited by 1,133
The connectome of an insect brain
Winding, M., Pedigo, B. D., Barnes, C. L., Patsolic, H. G., Park, Y., Kazimiers, T., Fushiki, A., Andrade, I. V., Khandelwal, A., Valdes-Aleman, J., et al. (2023) · Science · doi:10.1126/science.add9330 · Cited by 435
Whole-brain annotation and multi-connectome cell typing of Drosophila
Schlegel, P., Yin, Y., Bates, A. S., Dorkenwald, S., Eichler, K., Brooks, P., Han, D. S., Gkantia, M., dos Santos, M., Munnelly, E. J., et al. (2024) · Nature · doi:10.1038/s41586-024-07686-5 · Cited by 413
Metadata
- Authors
- Pascual, A., Huang, K.-L., Neveu, J., & Préat, T.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Préat, Thomas
- Venue
- Nature
- Published
- 2004-02
- Volume
- 427
- Issue
- 6975
- Pages
- 605-606
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2091960120
- Cited by
- 208
- References
- 9
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 12 · 2023: 15 · 2022: 5 · 2021: 7 · 2020: 9 · 2019: 13 · 2018: 8 · 2017: 8 · 2016: 5 · 2015: 8 · 2014: 9 · 2013: 5 · 2012: 14
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- brain asymmetry, brain laterality, long-term memory, short-term memory, Drosophila, neural structures, memory retrieval, cognitive skills
- MeSH terms
- Animals, Brain, Conditioning, Psychological, Drosophila melanogaster, Electroshock, Female, Functional Laterality, Male, Memory, Memory, Short-Term, Odorants, Smell, Time Factors
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