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Casein kinase I transduces Wnt signals
Abstract
The Wnt signalling cascade is essential for the development of both invertebrates and vertebrates, and is altered during tumorigenesis. Although a general framework for Wnt signalling has been elucidated, not all of the components have been identified. Here we describe a serine kinase, casein kinase I (CKI), which was isolated by expression cloning in Xenopus embryos. CKI reproduces several properties of Wnt signals, including generation of complete dorsal axes, stabilization of beta-catenin and induction of genes that are direct targets of Wnt signals. Dominant-negative forms of CKI and a pharmacological blocker of CKI inhibited Wnt signals in Xenopus. Inhibiting CKI in Caenorhabditis elegans generated worms with a mom phenotype, indicative of a loss of Wnt signals. In addition, CKI bound to and increased the phosphorylation of dishevelled, a known component of the Wnt pathway. These data indicate that CKI may be a conserved component of the Wnt pathway.
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“Dsh is phosphorylated by a number of kinases including Casein Kinase 1,37 Casein Kinase 2,38 Metastasis Associated Kinase,39 Protein Kinase C40 and Par1.41”
From Wnt signal transduction pathways (2008) · cites this paper as [37]
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Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Site-directed mutagenesis by overlap extension using the polymerase chain reaction
Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., & Pease, L. R. (1989) · Gene · doi:10.1016/0378-1119(89)90358-2 · Cited by 7,414
Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
Wnt signaling: a common theme in animal development
Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567
Nusse, R., & VARMUS, H. E. (1982) · Cell · doi:10.1016/0092-8674(82)90409-3 · Cited by 1,864
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos
Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824
A new member of the frizzled family from Drosophila functions as a Wingless receptor
Bhanot, P., van den Brink, M. R. M., Samos, C. H., Hsieh, J.-C., Wang, Y., Macke, J. P., Andrew, D. J., Nathans, J., & Nusse, R. (1996) · Nature · doi:10.1038/382225a0 · Cited by 1,504
Chien, C., Bartel, P. L., Sternglanz, R., & Fields, S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.21.9578 · Cited by 1,494
Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines
Rubinfeld, B., Robbins, P. F., El‐Gamil, M., Albert, I., Porfiri, E., & Polakis, P. G. (1997) · Science · doi:10.1126/science.275.5307.1790 · Cited by 1,223
Yost, C., Torres, M., Miller, J., Huang, E., Kimelman, D., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.12.1443 · Cited by 1,167
Research works printed but not linked: 1
- Epstein,H. & Shakes,D. in Methods in Cell Biology (eds Wilson, L. & Matsudaira, P.) (Academic, San Diego, 1995).
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Waddell, D., Wang, X.-F., & Liberati, N. T. (2002) · Defense Technical Information Center (DTIC)
Tomaz, L. B., Liu, B. A., Ong, S. L. M., Tan, E. K., Meroshini, M., Tolwinski, N. S., Williams, C. S., Gingras, A., Leushacke, M., & Dunn, N. R. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.27.453941
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Li, Y., Li, Y., Chen, Y., Wang, M., Yang, J., Zhang, X., Zhu, L., Kong, J., & Min, L. (2021) · Figshare · doi:10.6084/m9.figshare.14650766
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Rahman, A., Das, A. K., Roy, J. K., Amandeep, A., McMullen, M. S., Flores, P., & Carlson, C. H. (2026) · The Plant Phenome Journal · doi:10.1002/ppj2.70120
Metadata
- Authors
- Peters, J. M., McKay, R. M., McKay, J. P., & Graff, J. M.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Graff, Jonathan M.
- ORCID
- McKay, Renée M.
- Venue
- Nature
- Published
- 1999-09
- Volume
- 401
- Issue
- 6751
- Pages
- 345-350
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2114511731
- Cited by
- 447
- References
- 50
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 3 · 2022: 8 · 2021: 13 · 2020: 12 · 2019: 15 · 2018: 9 · 2017: 15 · 2016: 7 · 2015: 11 · 2014: 21 · 2013: 17 · 2012: 12
- FWCI
- 11.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- casein kinase 1, Wnt signaling, signal transduction, β-catenin stabilization, dorsal axis formation, Xenopus embryo, dominant negative kinase, carcinogenesis
- MeSH terms
- Dishevelled Proteins, Animals, Cloning, Molecular, Cytoskeletal Proteins, Embryo, Nonmammalian, Enzyme Inhibitors, Epistasis, Genetic, Isoquinolines, Molecular Sequence Data, Mutation, Phosphoproteins, Phosphorylation, Protein Binding, Protein Kinases, Proto-Oncogene Proteins, Xenopus, Signal Transduction, Trans-Activators, Caenorhabditis elegans, Xenopus Proteins, Zebrafish Proteins, Casein Kinases, Protein Kinase Inhibitors, Adaptor Proteins, Signal Transducing, Wnt Proteins, beta Catenin
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