Cited by 458Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene RegulationHedgehog Signaling Pathway Studies

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Casein kinase I transduces Wnt signals

Peters, John M., McKay, Renée M., McKay, James P., Graff, Jonathan M.·1999·Nature

DOI 10.1038/43830

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Abstract

The Wnt signalling cascade is essential for the development of both invertebrates and vertebrates, and is altered during tumorigenesis. Although a general framework for Wnt signalling has been elucidated, not all of the components have been identified. Here we describe a serine kinase, casein kinase I (CKI), which was isolated by expression cloning in Xenopus embryos. CKI reproduces several properties of Wnt signals, including generation of complete dorsal axes, stabilization of beta-catenin and induction of genes that are direct targets of Wnt signals. Dominant-negative forms of CKI and a pharmacological blocker of CKI inhibited Wnt signals in Xenopus. Inhibiting CKI in Caenorhabditis elegans generated worms with a mom phenotype, indicative of a loss of Wnt signals. In addition, CKI bound to and increased the phosphorylation of dishevelled, a known component of the Wnt pathway. These data indicate that CKI may be a conserved component of the Wnt pathway.

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Authors: Peters, J. M., McKay, R. M., McKay, J. P., & Graff, J. M.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Graff, Jonathan M.
ORCID: McKay, Renée M.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1999-09
Volume: 401
Issue: 6751
Pages: 345-350
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/43830
OpenAlex: W2114511731
Cited by: 447
References: 50
Citations by year: 2026: 4 · 2025: 6 · 2024: 4 · 2023: 3 · 2022: 8 · 2021: 13 · 2020: 12 · 2019: 15 · 2018: 9 · 2017: 15 · 2016: 7 · 2015: 11 · 2014: 21 · 2013: 17 · 2012: 12
FWCI: 11.39
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
Keywords: casein kinase 1, Wnt signaling, signal transduction, β-catenin stabilization, dorsal axis formation, Xenopus embryo, dominant negative kinase, carcinogenesis
MeSH terms: Dishevelled Proteins, Animals, Cloning, Molecular, Cytoskeletal Proteins, Embryo, Nonmammalian, Enzyme Inhibitors, Epistasis, Genetic, Isoquinolines, Molecular Sequence Data, Mutation, Phosphoproteins, Phosphorylation, Protein Binding, Protein Kinases, Proto-Oncogene Proteins, Xenopus, Signal Transduction, Trans-Activators, Caenorhabditis elegans, Xenopus Proteins, Zebrafish Proteins, Casein Kinases, Protein Kinase Inhibitors, Adaptor Proteins, Signal Transducing, Wnt Proteins, beta Catenin

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Casein kinase I transduces Wnt signals

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