Treat obesity as physiology, not physics
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Insulin is the major hormone responsible for uptake of energy-rich substrates into liver, muscle, and adipose tissue when there is no insulin resistance.
“Insulin is the major hormone responsible for uptake of energy-rich substrates into liver, muscle, and adipose tissue when there is no insulin resistance.”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [12]
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Obesity in CKD--what should nephrologists know?
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Interaction of the endocrine system with inflammation: a function of energy and volume regulation
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“mainly by circulating glucose [12].”
Metabolic Reprogramming by Hexosamine Biosynthetic and Golgi N-Glycan Branching Pathways
Ryczko, M. C., Pawling, J., Chen, R., Rahman, A. M. A., Yau, K., Copeland, J. K., Zhang, C., Surendra, A., Guttman, D. S., Figeys, D., et al. (2016) · Scientific Reports · doi:10.1038/srep23043 · Cited by 119 · see citing works
Straub, R. H. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4688 · Cited by 98 · see citing works
“Particularly, high energy-dense carbohydrates are consumed too often, which induces inadequate hyperinsulinemia [65].”
BackgroundTraish, A. M. (2014) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000086 · Cited by 94 · see citing works
“Obesity is a chronic condition that cannot be ameliorated simply with lifestyle behavior alone [1,2].”
BackgroundLucan, S. C., & DiNicolantonio, J. J. (2014) · Public Health Nutrition · doi:10.1017/s1368980014002559 · Cited by 73 · see citing works
“By more-nuanced thinking, then, what counts for obesity and related diseases is not the number of calories in specific foods but rather the concentration and type of carbohydrates these foods contain((30,49,50)).”
BackgroundPhysiological handling of dietary fructose-containing sugars: implications for health
Campos, V. C., & Tappy, L. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.8 · Cited by 64 · see citing works
Li, D., Ferber, J. R., & Odouli, R. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.196 · Cited by 62 · see citing works
Testosterone a key factor in gender related metabolic syndrome
Bianchi, V. E., & Locatelli, V. (2018) · Obesity Reviews · doi:10.1111/obr.12633 · Cited by 61 · see citing works
“Obesity contributes substantially to metabolic disorders, and its treatment represents the first step of therapy of MetS (200).”
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Sharma, I., Liao, Y., Zheng, X., & Kanwar, Y. S. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.673556 · Cited by 57 · see citing works
“Although much advancements have been made in identifying the epigenetic markers of obesity, there is still a lack of information regarding tissue specific epigenetic markers of obesity (24).”
BackgroundInsights and challenges in usingC. elegansfor investigation of fat metabolism
Lemieux, G. A., & Ashrafi, K. (2014) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2014.959890 · Cited by 52 · see citing works
“…and energy expenditure can affect fat content of an organism, the problem with this nearly universally accepted conceptualization is that it largely ignores the wealth of wellestablished data showing that fat regulation in intact organisms is a physiological process (Atkinson, 2014; Taubes, 2012).”
BackgroundStenvinkel, P. (2014) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfu338 · Cited by 52 · see citing works
“This theory has recently been questioned [8].”
BackgroundNeural Regulatory Pathways of Feeding and Fat in Caenorhabditis elegans
Lemieux, G. A., & Ashrafi, K. (2015) · Annual Review of Genetics · doi:10.1146/annurev-genet-120213-092244 · Cited by 43 · see citing works
Macronutrients and obesity: Revisiting the calories in, calories out framework
Riera‐Crichton, D., & Tefft, N. (2014) · Economics & Human Biology · doi:10.1016/j.ehb.2014.04.002 · Cited by 38 · see citing works
Appetite, Energy Expenditure, and the Regulation of Energy Balance
ROSENBAUM, M. S. (2023) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2023.03.004 · Cited by 10 · see citing works
Childhood obesity: a (re) programming disease?
Paes, S. T., Gonçalves, C., Terra, M. M., Fontoura, T. S., Guerra, M. D. O., Peters, V., Mathias, P. C. D. F., & Andreazzi, A. (2015) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174415007837 · Cited by 13 · see citing works
Macronutrients and Obesity: Revisiting the Calories in, Calories out FrameworkPreprint
Riera‐Crichton, D., & Tefft, N. (2013) · SSRN Electronic Journal · doi:10.2139/ssrn.2279503 · Cited by 7 · see citing works
Obesity: Multiple factors contribute
Hamre, K. (2013) · Nature · doi:10.1038/493480c · Cited by 4 · see citing works
Gupta, H., & Bhandari, U. (2024) · Current Drug Targets · doi:10.2174/0113894501314788241008115712 · Cited by 4 · see citing works
Petzold, A. M., & Altrichter, S. L. (2023) · AJP Advances in Physiology Education · doi:10.1152/advan.00093.2023 · Cited by 2 · see citing works
Theoretical Advances in Type 2 Diabetes
Goel, P. (2017) · Handbook of statistics · doi:10.1016/bs.host.2017.07.001 · Cited by 2 · see citing works
Obesity: Appetite hormone weighs in
Guyenet, S. J. (2013) · Nature · doi:10.1038/493480d · Cited by 1 · see citing works
Stenvinkel, P. (2019) · Springer eBooks · doi:10.1007/978-3-319-97765-2_19 · Cited by 1 · see citing works
Andropause – gibt es das überhaupt?
Zitzmann, M. (2023) · Journal für Gynäkologische Endokrinologie/Schweiz · doi:10.1007/s41975-023-00306-x
- Authors
- Taubes, G.
- Corresponding author
- Taubes, Gary
- Venue
- Nature
- Published
- 2012-12-12
- Volume
- 492
- Issue
- 7428
- Pages
- 155-155
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2142250241
- Cited by
- 24
- References
- 0
- Citations by year
- 2024: 1 · 2023: 3 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 9 · 2013: 3
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- obesity, energy balance, hormonal regulation of appetite, adiposity, metabolism, obesity pathophysiology
- MeSH terms
- Clinical Trials as Topic, Hormones, Humans, Obesity, Research
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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