Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease

Kehoe, Patrick G., Russ, Carsten, McIlroy, Stephen, Williams, Hywel, Holmans, Peter, Holmes, Clive, Liolitsa, Danae, Vahidassr, Djamil +13 more·1999·Nature Genetics
DOI 10.1038/5009

Cited by (276)

Items 201–276 of 276

  1. Whole genome association analysis shows that ACE is a risk factor for Alzheimer's disease and fails to replicate most candidates from Meta-analysis.
    Jennifer Webster, Eric M. Reiman, Victoria Zismann, Keta D. Joshipura, John V. Pearson, Diane Hu‐Lince, Matthew J. Huentelman, David Wesley Craig, Keith D. Coon, Thomas Beach et al. · 2010 · PubMed Central
  2. Differences in allele frequencies of ACE I/D polymorphism between Northern and Southern Europe at different ages
    Francesco Panza, Cristiano A. Capurso, Alessia D’Introno, Anna Maria Colacicco, Patrick G. Kehoe, Davide Seripa, Alberto Pilotto, Antonio Capurso, Vincenzo Solfrizzi · 2006 · Atherosclerosis
  3. Angiotensin Converting Enzyme 1 Expression in the Leukocytes of Adults Aged 64 to 67 Years
    Valquíria Bueno, Pedro Henrique Destro, Daniela Teixeira, Daniela Frasca · 2022 · JMIRx Med
  4. ACE Phenotyping in Human Blood and Tissues: Revelation of ACE Outliers and Sex Differences in ACE Sialylation
    Enikő Edit Enyedi, Pavel A. Petukhov, Alexander J. Kozuch, Steven M. Dudek, Attila Tóth, Miklós Fagyas, Sergei M. Danilov · 2024 · Biomedicines
  5. Exclusion of Angiotensin I-Converting Enzyme as a Candidate Gene Involved In Exudative Inflammatory Resistance in F344/N Rats
    Mehrnaz Jafarian-Tehrani, Samuel J. Listwak, Ruth M. Barrientos, Annie Michaud, Pierre L. Corvol, Esther M. Sternberg · 2000 · Molecular Medicine
  6. Effect of ACE mutations on blood ACE phenotype parameters
    Olga V. Kryukova, Dmitriy O. Korostin, Vera Аlexandrovna Belova, Valery V. Cheranev, Zhanna A. Repinskaia, I. V. Uporov, Steven M. Dudek, Olga A. Kost, Denis V. Rebrikov, Sergei M. Danilov · 2024 · PLoS ONE
  7. Fast high-throughput screening of angiotensin-converting enzyme insertion/deletion polymorphism by variable programmed electric field strength-based microchip electrophoresis
    Yucheng Sun, Su Kang Kim, Peng Zhang, Nain Woo, Seong Ho Kang · 2016 · Journal of Chromatography B
  8. ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial
    Christos Rossios, Tufail Bashir, Marcus Achison, Simon Adamson, Asangaedem Akpan, Terry Aspray, Alison Avenell, Margaret M. Band, Louise A. Burton, Vera Cvoro et al. · 2023 · PLoS ONE
  9. Is the Relationship Between Cardiovascular Disease and Alzheimer’s Disease Genetic? A Scoping Review
    Anni K. Moore, Marylyn DeRiggi Ritchie · 2024 · Genes
  10. Angiotensin I converting enzyme polymorphism effects in patients with normal pressure hydrocephalus syndrome before and after surgery
    Maria Mar Matar�n, Maria Antonia Poca, David Bartrés-faz A, Maria Matar�, Imma C. Clemente, Cristina Solé‐Padullés, Emili Gonz�lez-P�rez, Pedro Moral, Maite Barrios, Carme Junqué et al. · 2005 · Journal of Neurology
  11. Contributing Factors of Neurodegeneration in Alzheimer’s Disease
    Breeya A Tailor, Alexander R. Pilozzi, Xudong Huang · 2019 · Codon Publications eBooks
  12. Association of Angiotensin-Converting Enzyme gene polymorphism and Alzheimer's risk in Kashmiri population
    Kamran Nissar, Insha Rauf, Arshad Hussain, Parvaiz Ahmad Shah, Bashir Ahmad Ganai · 2021 · Gene Reports
  13. Effects of Angiotensin-I-Converting Enzyme (ACE) Mutations Associated with Alzheimer’s Disease on Blood ACE Phenotype
    Olga V. Kryukova, Igor O. Islanov, Elena V. Zaklyazminskaya, Dmitriy O. Korostin, Vera Belova, Valery V. Cheranev, Zhanna A. Repinskaia, Svetlana A. Tonevitskaya, Pavel A. Petukhov, Steven M. Dudek et al. · 2024 · Biomedicines
  14. ACE-dependent Alzheimer's disease: Further assessment of the impact of ACE mutations on blood ACE levels
    Ekaterina A. Korf, Daria A. Belinskaia, Andrei S. Glotov, Oleg S. Glotov, Yulia S. Novokovich, Dmitriy O. Korostin, Denis V. Rebrikov, Steven M. Dudek, Nikolay V. Goncharov, Sergei M. Danilov · 2025 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  15. ACE-Dependent Alzheimer’s Disease: Circulating ACE Phenotypes in Heterozygous Carriers of Rare ACE Variants
    Iaroslav V. Mironenko, Olga V. Kryukova, Anastasiia A. Buianova, Alexey Viktorovich Churov, Mikhail S. Arbatsky, Alyona A. Kubrikova, Yunna S. Petrusenko, Zhanna A. Repinskaia, Anna O. Shmitko, Galit A. Ilyina et al. · 2025 · International Journal of Molecular Sciences
  16. Relation of Apo E and ACE genes to cognitive performance in chronic alcoholic patients
    David Bartrés-faz A, Imma C. Clemente, Miquel Monràs, Miguel Ponce Muñoz, Antoni López‐Alomar, Neus Valveny, Pedro Moral, Antoni Gual, M. Sánchez-Turet, J. GUARDIA et al. · 2002 · Addiction Biology
  17. Favourable outcome of a brain trauma patient despite bilateral loss of cortical somatosensory evoked potential during thiopental sedation
    Pierre A. J. T. Robe · 2003 · Journal of Neurology Neurosurgery & Psychiatry
  18. How does “Protein Corona” Affect the In vivo Efficiency of Polymeric Nanoparticles? State of Art
    2017 · BENTHAM SCIENCE PUBLISHERS eBooks
  19. ACE and LRPAP1 Insertion-Deletion Polymorphisms in a Northern Ivory Coast Population
    Alfredo Santovito, Claudio Bulgarello, G. A. Caravatti, M. Ouattará, Piero Cervella, G. Pisano, Bruna Salvarani, Massimiliano Delpero · 2007 · Human Biology
  20. The relationship between angiotensin-converting enzyme (ACE) insertion (I) / deletion (D) polymorphism, serum ACE activity and bone mineral density (BMD) in older Chinese
    Yafeng Zhang, Hong Wang, Qiong Cheng, Ling Qin, Nelson L.S. Tang, Ping-chong Leung, Timothy C. Y. Kwok · 2017 · Journal of the Renin-Angiotensin-Aldosterone System
  21. acn-1, aC. eleganshomologue ofACE, genetically interacts with thelet-7microRNA and other heterochronic genes
    Chanatip Metheetrairut, Yuri Ahuja, Frank John Slack · 2017 · Cell Cycle
  22. Allelic frequencies at the ACE and LRPAP1 loci suggest age-related relationships in a Northern Italian population
    Alfredo Santovito, Claudio Bulgarello, Piero Cervella, Maria Paola Bigatti, Massimiliano Delpero · 2007 · Annals of Human Biology
  23. Molecular Determinants of Human Longevity
    Francesco Panza, Alessia D’Introno, Anna Maria Colacicco, Cristiano A. Capurso, Rosa Palasciano, Sabrina A. Capurso, Annamaria Gadaleta, Antonio Capurso, Patrick G. Kehoe, Vincenzo Solfrizzi · 2005 · Advances in clinical chemistry
  24. Polymorphisms of toxifying and detoxifying hepatic enzymes in amyotrophic lateral sclerosis
    Rainer Bachus · 2003 · Journal of Neurology Neurosurgery & Psychiatry
  25. Alzheimer's Disease
    Richard P Mayeux, Sam Gandy · 2000 · Elsevier eBooks
  26. Faculty Opinions recommendation of Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
    Riqiang Yan · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  27. Angiotensin converting enzyme (ACE) 1 expression in leukocytes of adults from 64 to 67 years old
    Valquíria Bueno, Pedro Henrique Destro, Daniela Teixeira, Daniela Frasca · 2022 · medRxiv
  28. Angiotensin Converting Enzyme (ACE) expression in microglia reduces amyloid β deposition and neurodegeneration by increasing SYK signaling and endolysosomal trafficking
    Andrew R. Gomez, Hyae Ran Byun, Shaogen Wu, AKM Ghulam Muhammad, Jasmine Ikbariyeh, Jaelin Chen, Alek Muro, Lin Li, Kenneth E. Bernstein, Richard I. Ainsworth et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  29. ACE-Dependent Alzheimer’s Disease: Blood ACE Phenotyping of the Most Prevalent and Damaging ACE Missense Mutation—Y215C (rs3730025)
    Anastasiia A. Buianova, Ivan A. Adzhubei, Olga V. Kryukova, Olga A. Kost, Iaroslav V. Mironenko, Alexander J. Kozuch, Galit A. Ilyina, Anna A. Kuznetsova, Zhanna A. Repinskaia, Alexey Viktorovich Churov et al. · 2026 · Biomedicines
  30. A review of plant-derived products regulating amyloid beta-degrading enzymes in Alzheimer’s disease
    Benyamin Honaramouz, Mohsen Imenshahidi, Hossein Hosseinzadeh · 2026 · Phytomedicine
  31. Trait, State, and Mechanism: Looking Back, Looking Forward, and Understanding Why
    Simon Lovestone · 2012 · Journal of Alzheimer s Disease
  32. Lack of association between two ACE gene polymorphisms (rs4291 and Alu I/D) and late onset Alzheimer's disease
    P. Yenki, Zahra Safari, C. Azimi · 2012 · AFRICAN JOURNAL OF BIOTECHNOLOGY
  33. Catabolism and Anabolism of Amyloid-β
    Shoko Hashimoto, Per Nilsson, Takaomi C. Saido · 2015 · Springer eBooks
  34. The association between ACE I/D polymorphism and the risk of Alzheimer's disease in Lebanon
    Saïd El Shamieh, Fatima Saleh, Niveen Masri, Hana M. A. Fakhoury, Rajaa Fakhoury · 2018 · Meta Gene
  35. Is the Role of the Angiotensin-Converting Enzyme Gene in Alzheimer's Disease Independent of Hypertension?
    Yuan‐Han Yang, Yuan‐Han Yang, Shyh-Jong Wu, Chinchun Huang, Jong‐Ling Fuh, Chingkuan Liu, Shyh-Jong Wu, Chinchun Huang, Jong‐Ling Fuh, Chingkuan Liu · 2017 · Translational Neuroscience and Clinics
  36. Amyloid-β in Brain Aging and Alzheimer’s Disease
    Hiroki Sasaguri, Takaomi C. Saido · 2022 · Springer eBooks
  37. Genomics and proteomics are changing discovery, development and clinical use of dementia drugs
    Hermann AM Mucke · 2007 · Expert Opinion on Drug Discovery
  38. Modulation der neutralen Endopeptidase im humanen Zellkultursystem durch pflanzliche Drogenextrakte und Naturstoffe
    Shereen Ayoub · 2007 · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver
  39. Lokalny układ renina-angiotensyna - nowy łącznik pomiędzy mózgiem a tarczycą?
    Mariusz Stasiołek, Andrzej Lewiñski · 2011
  40. The value of haplotypes
    Anne René de Vries · 2009 · University of Groningen research database (University of Groningen / Centre for Information Technology)
  41. Neural stem cell biology and neurogenesis in mouse models of aging and Alzheimer's disease
    Florian Ermini · 2006 · edoc (University of Basel)
  42. Endosomes élargis et cholestérol : De la trisomie 21 à la maladie d'Alzheimer
    Jack‐Christophe Cossec · 2009 · OpenGrey (Institut de l'Information Scientifique et Technique)
  43. Genetics: Alzheimer disease.
    Heather Dorman, Wendy S. Meschino, Judith E Allanson, Sean Blaine, Carol Cremin, Clare Gibbons, Christina R. Honeywell, Joanne Permaul, June C. Carroll · 2009 · PubMed Central
  44. Avaliação de polimorfismos de DNA em genes candidatos de pacientes com comprometimento cognitivo leve e doença de Alzheimer
    Giselle Izzo · 2010
  45. The angiotensin-converting enzyme gene insertion–deletion polymorphism in a white British patient cohort with obstetric cholestasis
    Roman Müllenbach, Natasha Tetlow, Amanda J. Bennett, Fiona Broughton Pipkin, Linda Morgan, Catherine Williamson · 2009 · Obstetric Medicine
  46. THE ROLE OF ANGIOTENSIN-(1-7) IN CARDIOVASCULAR PHYSIOLOGY
    Justin L. Grobe · 2006
  47. Evaluating the Potential Therapeutic Role of Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers for Alzheimer's Disease using a Drosophila Model
    Sarah Gomes · 2017
  48. Genetic Risk Factors for Complex Forms of Alzheimer’s Disease
    Céline Bellenguez, Jean‐Charles Lambert · 2018 · Springer eBooks
  49. P1–291: Angiotensin converting enzyme insertion/deletion polymorphism in sporadic and familial Alzheimer's disease and longevity
    Sandro Sorbi · 2006 · Alzheimer s & Dementia
  50. The geographic distribution of the ACE II genotype : a novel finding
    Y. B. S Aab, A. D. J. O Verall · 2007
  51. Additional file 7 of A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
    Yanfa Sun, Jingjing Zhu, Dan Zhou, Saranya Canchi, Chong Wu, Nancy Jean Cox, Robert A. Rissman, Eric R. Gamazon, Lang Wu · 2021 · Figshare
  52. Additional file 1 of A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
    Yanfa Sun, Jingjing Zhu, Dan Zhou, Saranya Canchi, Chong Wu, Nancy Jean Cox, Robert A. Rissman, Eric R. Gamazon, Lang Wu · 2021 · Figshare
  53. Additional file 9 of A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
    Yanfa Sun, Jingjing Zhu, Dan Zhou, Saranya Canchi, Chong Wu, Nancy Jean Cox, Robert A. Rissman, Eric R. Gamazon, Lang Wu · 2021 · Figshare
  54. Additional file 10 of A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
    Yanfa Sun, Jingjing Zhu, Dan Zhou, Saranya Canchi, Chong Wu, Nancy Jean Cox, Robert A. Rissman, Eric R. Gamazon, Lang Wu · 2021 · Figshare
  55. Additional file 5 of A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
    Yanfa Sun, Jingjing Zhu, Dan Zhou, Saranya Canchi, Chong Wu, Nancy Jean Cox, Robert A. Rissman, Eric R. Gamazon, Lang Wu · 2021 · Figshare
  56. Additional file 3 of A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
    Yanfa Sun, Jingjing Zhu, Dan Zhou, Saranya Canchi, Chong Wu, Nancy Jean Cox, Robert A. Rissman, Eric R. Gamazon, Lang Wu · 2021 · Figshare
  57. Additional file 13 of A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
    Yanfa Sun, Jingjing Zhu, Dan Zhou, Saranya Canchi, Chong Wu, Nancy Jean Cox, Robert A. Rissman, Eric R. Gamazon, Lang Wu · 2021 · Figshare
  58. Additional file 4 of A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
    Yanfa Sun, Jingjing Zhu, Dan Zhou, Saranya Canchi, Chong Wu, Nancy Jean Cox, Robert A. Rissman, Eric R. Gamazon, Lang Wu · 2021 · Figshare
  59. Additional file 8 of A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
    Yanfa Sun, Jingjing Zhu, Dan Zhou, Saranya Canchi, Chong Wu, Nancy Jean Cox, Robert A. Rissman, Eric R. Gamazon, Lang Wu · 2021 · Figshare
  60. Additional file 2 of A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
    Yanfa Sun, Jingjing Zhu, Dan Zhou, Saranya Canchi, Chong Wu, Nancy Jean Cox, Robert A. Rissman, Eric R. Gamazon, Lang Wu · 2021 · Figshare
  61. Additional file 6 of A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
    Yanfa Sun, Jingjing Zhu, Dan Zhou, Saranya Canchi, Chong Wu, Nancy Jean Cox, Robert A. Rissman, Eric R. Gamazon, Lang Wu · 2021 · Figshare
  62. Additional file 11 of A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
    Yanfa Sun, Jingjing Zhu, Dan Zhou, Saranya Canchi, Chong Wu, Nancy Jean Cox, Robert A. Rissman, Eric R. Gamazon, Lang Wu · 2021 · Figshare
  63. The Contribution of the Renin-Angiotensin System to Alzheimer’s Disease
    Özge Güzel, Patrick G. Kehoe · 2024 · Current topics in behavioral neurosciences
  64. Association Between Angiotensin‐Converting Enzyme (ACE) Gene Insertion/Deletion (I/D) Polymorphism Genotypes With Brain Volume and Hypertension in Alzheimer's Disease—A Retrospective Study
    Bin‐Tse Lin, Ching‐Fang Chien, Ling‐Chun Huang, Yuan‐Han Yang · 2025 · The Kaohsiung Journal of Medical Sciences
  65. Additional file 12 of A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
    Sun, Yanfa, Jingjing Zhu, Zhou, Dan, Saranya Canchi, Wu, Chong, Nancy Jean Cox, Robert A. Rissman, Eric R. Gamazon, Wu, Lang · 2021 · Figshare
  66. Additional file 1 of Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits
    William P. Bone, Katherine M. Siewert, Jha, Anupama, Derek M. Klarin, Scott M. Damrauer, Chang, Kyong-Mi, Philip S. Tsao, Themistocles L. Assimes, Marylyn DeRiggi Ritchie, Benjamin F. Voight · 2021 · Figshare
  67. Métalloprotéases matricielles et maladie d'Alzheimer : étude du rôle de MT1-MMP dans le métabolisme de l'APP/Aß
    Nathalie A. Py · 2014 · theses.fr (ABES)
  68. Molecular mechanisms of action of MT-MMPs involved in the pathogenesis of Alzheimer’s disease
    Laura García‐González · 2020 · theses.fr (ABES)
  69. Métalloprotéases matricielles et maladie d'Alzheimer : étude des rôles de MT1- et MT5-MMP dans l'amyloïdogenèse et la neuro-inflammation
    Jean‐Michel Paumier · 2018 · theses.fr (ABES)
  70. Implication du fragment C99 dans l’avènement des phénotypes pathologiques de la maladie d’Alzheimer
    Alexandre Bourgeois · 2019 · theses.fr (ABES)
  71. MT5-MMP promotes neuroinflammation, pathogenic processing of amyloid precursor protein and synaptic dysfunction at early stages in an Alzheimer's disease model
    Dominika Piłat · 2021 · theses.fr (ABES)
  72. Integration of multi-omics and artificial intelligence for therapeutic insights in Alzheimer's disease: A comprehensive review
    Tamilarasi Sambu Periyasamy, Nishu Sekar, Hariprasath Lakshmanan · 2026 · Journal of Alzheimer s Disease
  73. Classification of ACE variants related to Alzheimer’s disease (AD): the ACE mutations — AD browser
    Anastasiia A. Buianova, Ivan A. Adzhubei, Petr A. Buianov, Olga V. Kryukova, Olga A. Kost, Mikhail Iu. Kuznetsov, Steven M. Dudek, Denis V. Rebrikov, Sergei M. Danilov · 2026 · medRxiv
  74. Circulating Oxidative Damage and Antioxidant Defense System Biomarkers in Early Stage Alzheimer’s Disease
    Marı́a Jesús Ramı́rez-Expósito, José Manuel Martı́nez-Martos · 2014 · Elsevier eBooks
  75. Environmental Studies as a Tool for Detecting Epigenetic Mechanisms in Schizophrenia
    Wim Veling, Lambert H. Lumey, Bas T. Heijmans, Ezra Susser · 2011 · Springer eBooks
  76. Angiotensin-converting enzyme levels and activity in Alzheimer's disease: differences in brain and CSF ACE and association with ACE1 genotypes.
    2009 · PubMed Central