The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease
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Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“which is a known blood pressure and AD association”
From Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits (2021) · cites this paper as [35]
In the citing paper
“ACE and ADAM10 were previously reported as Alzheimer’s disease candidate genes18–22 but were not replicated in some subsequent studies23–25.”
From Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) · cites this paper as [20]
In the citing paper
“Candidate gene studies have associated ACE variants with Alzheimer’s disease risk20,22,79, including a strong association in the Wadi Ara, an Israeli Arab community with high risk of Alzheimer’s disease21.”
From Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) · cites this paper as [20]
Citations
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Rigat, B., Hubert, C., Alhenc-Gelas, F., Cambien, F., Corvol, P., & Soubrier, F. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114844 · Cited by 3,767
ON ESTIMATING THE RELATION BETWEEN BLOOD GROUP AND DISEASE
Woolf, B. (1955) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1955.tb01348.x · Cited by 2,724
Rigat, B. A., Hübert, C., Corvol, P. L., & Soubrier, R. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.6.1433-a · Cited by 1,237
Genetic associations with human longevity at the APOE and ACE loci
Schächter, F., Faure-Delanef, L., Guénot, F., Rouger, H., Froguel, P., Lesueur-Ginot, L., & Cohen, D. (1994) · Nature Genetics · doi:10.1038/ng0194-29 · Cited by 1,095
Apolipoprotein E genotyping by one-stage PCR
Wenham, P. R., Price, W. H., & Blundell, G. (1991) · The Lancet · doi:10.1016/0140-6736(91)92823-k · Cited by 1,070
Lindpaintner, K., Pfeffer, M. A., Kreutz, R. H., Stampfer, M. J., Grodstein, F., Lamotte, F., Buring, J. E., & Hennekens, C. H. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503163321103 · Cited by 899
Angiotensin-converting enzyme: new concepts concerning its biological role.
Ehlers, M., & Riordan, J. (1989) · Biochemistry · doi:10.1021/bi00439a001 · Cited by 395
Genetic susceptibility to Alzheimer disease
Pericak‐Vance, M. A., & Haines, J. L. (1995) · Trends in Genetics · doi:10.1016/s0168-9525(00)89161-1 · Cited by 126
Attenuation of scopolamine-induced spatial learning impairments by an angiotensin IV analog
Pederson, E. S., Harding, J. W., & Wright, J. W. (1998) · Regulatory Peptides · doi:10.1016/s0167-0115(98)00028-7 · Cited by 103
Research works printed but not linked: 1
- McIlroy, S.P. et al. Am. J. Med. Genet. (in press).
Cited by
Sorted by citations
Alzheimer Disease Genetics Consortium (ADGC), Kunkle, B. W., The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, P. A. E. R. F. A. D. C. (., Grenier-Boley, B., Sims, R., Bis, J. C., Damotte, V., Naj, A. C., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0358-2 · Cited by 2,946
Self-citationThe Genetics of Alzheimer Disease: Back to the Future
Bertram, L., Lill, C. M., & Tanzi, R. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.013 · Cited by 834
The Genetics of Alzheimer's Disease
Bertram, L., & Tanzi, R. E. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385883-2.00008-4 · Cited by 794
The genetics of Alzheimer disease
Tanzi, R. E. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006296 · Cited by 727
“ACE is also able to degrade Ab in vitro (Hu et al. 2001; Hemming et al. 2005).”
BackgroundThirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses
Bertram, L., & Tanzi, R. E. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2494 · Cited by 747
Metadata
- Authors
- Kehoe, P. G., Russ, C., McIlroy, S., Williams, H., Holmans, P., Holmes, C., Liolitsa, D., Vahidassr, D., Powell, J., McGleenon, B., Liddell, M., Plomin, R., Dynan, K., Williams, N., Neal, J., Cairns, N. J., Wilcock, G., Passmore, P., Lovestone, S., Williams, J., & Owen, M. J.
- Affiliations
- Cardiff University (GB)
- Queen's University Belfast (GB)
- Medical Research Council (GB)
- Frenchay Hospital (GB)
- Corresponding author
- Owen, Michael J.
- ORCID
- Venue
- Nature Genetics
- Published
- 1999-01
- Volume
- 21
- Issue
- 1
- Pages
- 71-72
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- DOI
- 10.1038/5009
- OpenAlex
- W2102952062
- Cited by
- 260
- References
- 14
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 3 · 2019: 11 · 2018: 7 · 2017: 10 · 2016: 5 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 10
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Explore Bristol Research (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- DCP1, ACE, angiotensin-converting enzyme, Alzheimer's disease, genetic susceptibility, genetic association, renin-angiotensin system
- MeSH terms
- Alleles, Alzheimer Disease, Apolipoproteins E, Cardiovascular Diseases, Genotype, Humans, Peptidyl-Dipeptidase A, Endopeptidases, Genetic Variation, Case-Control Studies, Genetic Predisposition to Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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