A long journey to reproducible results
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Lack of reproducibility may herald genuine heterogeneity in biological and experimental systems that is poorly controlled or not well understood.
“It may herald genuine heterogeneity in biological and experimental systems5,6 that is poorly controlled or not well understood.”
From How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation (2018) · cites this paper as [5]
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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868 · see citing works
Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics
Melov, S., Ravenscroft, J., Malik, S., Gill, M. S., Walker, D. W., Clayton, P., Wallace, D. C., Malfroy, B., Doctrow, S. R., & Lithgow, G. J. (2000) · Science · doi:10.1126/science.289.5484.1567 · Cited by 913 · see citing works
Self-citationAbsence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
Burnett, C., Valentini, S., Cabreiro, F., Goss, M., Somogyvári, M., Piper, M. D., Hoddinott, M., Sutphin, G. L., Leko, V., McElwee, J. J., et al. (2011) · Nature · doi:10.1038/nature10296 · Cited by 624 · see citing works
Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans
Bass, T. M., Weinkove, D., Houthoofd, K., Gems, D., & Partridge, L. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.07.007 · Cited by 435 · see citing works
An antidepressant that extends lifespan in adult Caenorhabditis elegans
Petrascheck, M., Ye, X., & Buck, L. B. (2007) · Nature · doi:10.1038/nature05991 · Cited by 287 · see citing works
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Sorting Out the FACS: A Devil in the Details
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Molecular hyperdiversity and evolution in very large populations
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Factors affecting reproducibility between genome-scale siRNA-based screens
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Ioannidis, J. P. A., Kim, B. Y. S., & Trounson, A. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0314-y · Cited by 175 · see citing works
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Gundersen, O. E., Gil, Y., & Aha, D. W. (2018) · AI Magazine · doi:10.1609/aimag.v39i3.2816 · Cited by 99 · see citing works
Reproducibility failures are essential to scientific inquiry
Redish, A. D., Kummerfeld, E., Morris, R. L., & Love, A. C. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1806370115 · Cited by 66 · see citing works
- Authors
- Lithgow, G. J., Driscoll, M., & Phillips, P.
- Affiliations
- Buck Institute for Research on Aging (US)
- Rutgers, The State University of New Jersey (US)
- University of Oregon (US)
- Corresponding author
- Lithgow, Gordon J.
- Venue
- Nature
- Published
- 2017-08
- Volume
- 548
- Issue
- 7668
- Pages
- 387-388
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5762131
- OpenAlex
- W2747311934
- Cited by
- 157
- References
- 13
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 16 · 2023: 13 · 2022: 2 · 2021: 21 · 2020: 32 · 2019: 21 · 2018: 25 · 2017: 4 · 2015: 1
- FWCI
- 9.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institute on Aging (R01AG029631, U01AG045829, U01AG045864, U24AG056052)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Social Sciences › Decision Sciences › Information Systems and Management › Scientific Computing and Data Management
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy and History of Science
- Keywords
- reproducibility, replication study, Caenorhabditis elegans, scientific rigor
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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