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Fast synaptic fatigue in shibire mutants reveals a rapid requirement for dynamin in synaptic vesicle membrane trafficking

Kawasaki, Fumiko, Hazen, Missy, Ordway, Richard W.·2000·Nature Neuroscience
DOI 10.1038/78753
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Abstract

The GTPase dynamin is involved in endocytosis in many cell types, as first revealed by temperature-sensitive paralytic mutations in the Drosophila dynamin gene, shibire (shi), which disrupt synaptic vesicle endocytosis and deplete synaptic terminals of vesicles. Here we report that shi synapses exhibit a fast synaptic fatigue phenotype within 20 ms of repetitive stimulation, which cannot be explained by vesicle depletion, as we confirmed by electron microscopy. These results suggest that, in addition to its well-characterized role in synaptic vesicle recycling, dynamin may be required for short-term maintenance of the readily releasable pool of synaptic vesicles.

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Crossref · 10.1038/78753

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Research works printed but not linked: 15

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Metadata

Authors
Kawasaki, F., Hazen, M., & Ordway, R. W.
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2000-09
Volume
3
Issue
9
Pages
859-860
ISSN
  • 1097-6256
  • 1546-1726
DOI
10.1038/78753
Cited by
117
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

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