Cited by 1,383Atherosclerosis and Cardiovascular DiseasesImmunotherapy and Immune ResponsesLipoproteins and Cardiovascular Health

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Statins as a newly recognized type of immunomodulator.

Kwak, Brenda, Mulhaupt, Flore, Myit, Samir, Mach, François·2000·Nature Medicine

DOI 10.1038/82219

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Abstract

Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, or statins, are effective lipid-lowering agents, extensively used in medical practice. Statins have never been shown to be involved in the immune response, although a report has indicated a better outcome of cardiac transplantation in patients under Pravastatin therapy. Major histocompatibility complex class II (MHC-II) molecules are directly involved in the activation of T lymphocytes and in the control of the immune response. Whereas only a limited number of specialized cell types express MHC-II constitutively, numerous other cells become MHC-II positive upon induction by interferon gamma (IFN-gamma). This complex regulation is under the control of the transactivator CIITA (refs 6,7). Here we show that statins act as direct inhibitors of induction of MHC-II expression by IFN-gamma and thus as repressors of MHC-II-mediated T-cell activation. This effect of statins is due to inhibition of the inducible promoter IV of the transactivator CIITA and is observed in several cell types, including primary human endothelial cells (ECs) and monocyte-macrophages (Mstraight phi). It is of note that this inhibition is specific for inducible MHC-II expression and does not concern constitutive expression of CIITA and MHC-II. In repressing induction of MHC-II, and subsequent T-lymphocyte activation, statins therefore provide a new type of immunomodulation. This unexpected effect provides a scientific rationale for using statins as immunosuppressors, not only in organ transplantation but in numerous other pathologies as well.

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Kobashigawa, J. A., Katznelson, S., Laks, H., Johnson, J. A., Yeatman, L., Wang, X. M., Chia, D., Terasaki, P. I., Sabad, A., Cogert, G. A., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509073331003 · Cited by 1,301
Current Perspectives on Statins
Maron, D. J., Fazio, S., & Linton, M. F. (2000) · Circulation · doi:10.1161/01.cir.101.2.207 · Cited by 1,216
Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA
Steimle, V., Siegrist, C.-A., Mottet, A., Lisowska-Grospierre, B., & Mach, B. (1994) · Science · doi:10.1126/science.8016643 · Cited by 898
Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)
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Hebert, P. R. (1997) · JAMA · doi:10.1001/jama.1997.03550040069040 · Cited by 740
Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40–CD40 ligand signaling in atherosclerosis
Mach, F., Schönbeck, U., Sukhova, G. K., Bourcier, T., Bonnefoy, J., Pober, J. S., & Libby, P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.1931 · Cited by 730
Self-citation
Statins do more than just lower cholesterol
Vaughan, C. J., Murphy, M. B., & Buckley, B. M. (1996) · The Lancet · doi:10.1016/s0140-6736(96)05190-2 · Cited by 700
The evolving role of statins in the management of atherosclerosis
Vaughan, C. J., Gotto, A. M., & Basson, C. T. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00525-2 · Cited by 573
Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA
Mühlethaler‐Mottet, A., Otten, L., Steimle, V., & Mach, B. (1997) · The EMBO Journal · doi:10.1093/emboj/16.10.2851 · Cited by 507
Cholesterol Lowering With Statin Drugs, Risk of Stroke, and Total Mortality
Hebert, P. R., Gaziano, J. M., Chan, K. S., & Hennekens, C. H. (1998) · Survey of Anesthesiology · doi:10.1097/00132586-199806000-00060 · Cited by 506

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Chen, H.-H., Lin, C., Yeh, C.-J., Yeh, S.-Y., & Kao, C. (2015) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-015-2372-3 · Cited by 17
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Authors: Kwak, B., Mulhaupt, F., Myit, S., & Mach, F.
Affiliations: University Hospital of Geneva (CH)
Corresponding author: Mach, François
ORCID: Kwak, Brenda
Mach, François
Venue: Nature Medicine
Publisher: Springer Science and Business Media LLC
Published: 2000-12
Volume: 6
Issue: 12
Pages: 1399-1402
ISSN: 1078-8956 (ISSN-L)
1546-170X
DOI: 10.1038/82219
OpenAlex: W1525331105
Cited by: 1,383
References: 18
Citations by year: 2026: 14 · 2025: 18 · 2024: 26 · 2023: 27 · 2022: 25 · 2021: 33 · 2020: 33 · 2019: 35 · 2018: 29 · 2017: 39 · 2016: 37 · 2015: 53 · 2014: 55 · 2013: 44 · 2012: 56
FWCI: 23.50
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Nature Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: statins, immunomodulation, MHC class II induction, interferon-gamma, CIITA, T cell activation, endothelial cells, monocytes/macrophages, immunosuppression, organ transplantation, pravastatin
MeSH terms: Atorvastatin, Adjuvants, Immunologic, Anticholesteremic Agents, Endothelium, Vascular, Genes, MHC Class II, Heptanoic Acids, Humans, Interferon-gamma, Lovastatin, Lymphocyte Activation, Macrophages, Monocytes, Nuclear Proteins, Pyrroles, Saphenous Vein, T-Lymphocytes, Trans-Activators, Pravastatin, Hydroxymethylglutaryl-CoA Reductase Inhibitors

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Statins as a newly recognized type of immunomodulator.

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