Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis

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3. The TAM receptor Tyro3 regulates myelination in the central nervous system
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4. Platelet Interaction with the Vessel Wall
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5. Transforming growth factor-β–induced protein (TGFBIp/β ig-h3) activates platelets and promotes thrombogenesis
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6. TAM receptors Tyro3 and Mer as novel targets in colorectal cancer
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7. Development and Validation of an ELISA Method for Detection of Growth Arrest Specific 6 (GAS6) Protein in Human Plasma
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9. Molecular Imaging of Vulnerable Atherosclerotic Plaques in Animal Models
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10. Phase 1b study of AVB-500 in combination with paclitaxel or pegylated liposomal doxorubicin platinum-resistant recurrent ovarian cancer
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11. Gene of the month: Axl
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12. Stromal Gas6 promotes the progression of premalignant mammary cells
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13. Quantitative Differences in the Urinary Proteome of Siblings Discordant for Type 1 Diabetes Include Lysosomal Enzymes
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14. Targeting MERTK and AXL in EGFR Mutant Non-Small Cell Lung Cancer
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15. Association study between polymorphims in GAS6-TAM genes and carotid atherosclerosis
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16. GAS6 attenuates sepsis-induced cardiac dysfunction through NLRP3 inflammasome-dependent mechanism
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17. TAM receptor signaling in development
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18. Platelet Thrombus Formation in Flowing Blood
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19. Upregulated LINC00565 Accelerates Ovarian Cancer Progression By Targeting GAS6
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20. Dynamics of Axl Receptor Shedding in Hepatocellular Carcinoma and Its Implication for Theranostics
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21. Tyro3, Axl, and Mertk receptors differentially participate in platelet activation and thrombus formation
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22. Platelet protein S limits venous but not arterial thrombosis propensity by controlling coagulation in the thrombus
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23. Ginsenoside Rk1 suppresses platelet mediated thrombus formation by downregulation of granule release and αIIbβ3 activation
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24. ERK2 activation in arteriolar and venular murine thrombosis: platelet receptor GPIb vs. P2X1
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25. Role of the growth arrest-specific gene 6 (gas6) product in thrombus stabilization
    François Saller, Laurent Burnier, Marc Schapira, Anne Angelillo‐Scherrer · 2006 · Blood Cells Molecules and Diseases
26. The role of the vitamin K-dependent growth factor Gas6 in glomerular pathophysiology
    Motoko Yanagita · 2004 · Current Opinion in Nephrology & Hypertension
27. The small‐molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis
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28. Signal Transduction During Platelet Plug Formation
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29. Targeted inhibition of Axl receptor tyrosine kinase ameliorates anti-GBM-induced lupus-like nephritis
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30. Vitamin K antagonism impairs the bone marrow microenvironment and hematopoiesis
    Divij Verma, Rahul Kumar, Raquel S. Pereira, Christina Karantanou, Costanza Zanetti, Valentina R. Minciacchi, Keertik S. Fulzele, Kathrin Kunz, Soraya Hoelper, Sara Zia Chahabi et al. · 2019 · Blood
31. Modulation of Immune Responses by Platelet-Derived ADAM10
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32. TAM Signaling in the Nervous System
    Burstyn-Cohen, Tal, Hochberg, Arielle · 2021 · Brain Plasticity
33. Prostaglandin E synthase is upregulated by Gas6 during cancer-induced venous thrombosis
    Meghedi N. Aghourian, Catherine A. Lemarié, François Bertin, Mark D. Blostein · 2016 · Blood
34. Gas6-mediated signaling is dependent on the engagement of its gamma-carboxyglutamic acid domain with phosphatidylserine
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35. IL-6 as a Mediator of Platelet Hyper-Responsiveness
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36. Overexpressed Receptors and Proteins in Lung Cancer
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37. Elevated plasma gas6 levels are associated with venous thromboembolic disease
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38. Clearance of Apoptotic Cells and Pyrenocytes
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39. Gas6/TAM Receptors in Systemic Lupus Erythematosus
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40. Contact-dependent signaling events that promote thrombus formation
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41. Regulation of phagocytosis by TAM receptors and their ligands
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42. Gene Expression Profiles Link Respiratory Viral Infection, Platelet Response to Aspirin, and Acute Myocardial Infarction
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43. TYRO3: A potential therapeutic target in cancer
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44. Gas6 evaluation in patients with acute dyspnea due to suspected pulmonary embolism
    Pier Paolo Sainaghi, Federica Alciato, Stefania Carnieletto, Luigi Mario Castello, Luca Bergamasco, Daniele Sola, Angelo Sante Bongo, Eugenio Inglese, Riccardo Polosa, Gian Carlo Avanzi · 2008 · Respiratory Medicine
45. Elevation of Gas6 protein concentration in cerebrospinal fluid of patients with chronic inflammatory demyelinating polyneuropathy (CIDP)
    Pier Paolo Sainaghi, Laura Collimedaglia, Federica Alciato, Maurizio Angelo Leone, Erinda Puta, Paola Naldi, Luigi Mario Castello, Francesco Monaco, Gian Carlo Avanzi · 2008 · Journal of the Neurological Sciences
46. Development of a Novel Immunoassay for the Assessment of Plasma Gas6 Concentrations and Their Variation with Hormonal Status
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47. Phagocytosis of apoptotic cells in mammals, Caenorhabditis Elegans and drosophila Melanogaster: molecular mechanisms and physiological consequences
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48. Elevated Serum Gas6 Is a Novel Prognostic Biomarker in Patients with Oral Squamous Cell Carcinoma
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49. GAS6 in systemic inflammatory diseases: with and without infection
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50. Comprehensive Proteome Profiling of Platelet Identified a Protein Profile Predictive of Responses to An Antiplatelet Agent Sarpogrelate
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51. Vitamin K–Dependent Protein Activity and Incident Ischemic Cardiovascular Disease
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52. TAM receptors and the regulation of erythropoiesis in mice
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53. Serglycin Proteoglycan Deletion in Mouse Platelets
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54. P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries
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55. Using proteomics to identify potential therapeutic targets in platelets
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56. Having an Old Friend for Dinner: The Interplay between Apoptotic Cells and Efferocytes
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57. Opposing Roles of Tyrosine Kinase Receptors Mer and Axl Determine Clinical Outcomes in Experimental Immune-Mediated Nephritis
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58. Gintonin modulates platelet function and inhibits thrombus formation via impaired glycoprotein VI signaling
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59. Pleiotropic role of growth arrest-specific gene 6 in atherosclerosis
    Marc Tjwa, Lieve Moons, Esther Lutgens · 2009 · Current Opinion in Lipidology
60. Gas6 Stimulates Angiogenesis of Human Retinal Endothelial Cells and of Zebrafish Embryos via ERK1/2 Signaling
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61. Gas6/TAM Axis Involvement in Modulating Inflammation and Fibrosis in COVID-19 Patients
    Manuela Rizzi, Stelvio Tonello, Davide D’Onghia, Pier Paolo Sainaghi · 2023 · International Journal of Molecular Sciences
62. Genetic models for the clearance of apoptotic cells
    Philip L. Cohen, Roberto Caricchio · 2004 · Rheumatic Disease Clinics of North America
63. Early death in a mouse model of Alzheimer’s disease exacerbated by microglial loss of TAM receptor signaling
    Youtong Huang, Greg Lemke · 2022 · Proceedings of the National Academy of Sciences
64. Evaluation of targeting c-Src by the RGT-containing peptide as a novel antithrombotic strategy
    Jiansong Huang, Xiaofeng Shi, Wenda Xi, Ping Liu, Zhangbiao Long, Xiaodong Xi · 2015 · Journal of Hematology & Oncology
65. Is Gas6 Protein Associated With Sticky Platelet Syndrome?
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66. Role of Growth Arrest–Specific Gene 6 in the Development of Fungal Allergic Airway Disease in Mice
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67. Antibody‐mediated neutralization of autocrine Gas6 inhibits the growth of pancreatic ductal adenocarcinoma tumors in vivo
    Gordon E. Moody, Brian Belmontes, Stephanie K. Masterman, Wei Wang, Chadwick King, Christopher M. Murawsky, Trace S. Tsuruda, Shuying Liu, Robert Radinsky, Pedro J. Beltran · 2016 · International Journal of Cancer
68. Gas6 protein: its role in cardiovascular calcification
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69. Exogenous Gas6 attenuates silica-induced inflammation on differentiated THP-1 macrophages
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70. Physiological Plasma Gas6 Levels Do Not Influence Platelet Aggregation
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71. Role of Axl in T-Lymphocyte Survival in Salt-Dependent Hypertension
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74. The TAM receptor tyrosine kinases Axl and Mer drive the maintenance of highly phagocytic macrophages
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75. Involvement of neutrophils in thrombus formation in living mice
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76. Study of Early Elevated Gas6 Plasma Level as a Predictor of Mortality in a Prospective Cohort of Patients with Sepsis
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77. GAS6‐induced signaling in human endothelial cells is mediated by FOXO1a
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83. Sticky platelet syndrome: an important cause of life-threatening thrombotic complications
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84. Platelet Thrombus Formation in Flowing Blood
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85. Application of Proteomics to the Study of Platelet Regulatory Mechanisms
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89. Plasma levels of the growth arrest‐specific gene 6 product (Gas6) and antiplatelet drug responsiveness in healthy subjects
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91. Fonctions nouvelles de Gas-6 et de la protéine S
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99. In Vivo Models for the Evaluation of Antithrombotics and Thrombolytics
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100. Influence of the genetic background on platelet function, microparticle and thrombin generation in the common laboratory mouse
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