Cited by 1,137Muscle Physiology and DisordersNeurogenetic and Muscular Disorders ResearchGenetics and Physical Performance

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle

Musarò, Antonio, McCullagh, Karl, Paul, Angelika, Houghton, Leslie, Dobrowolny, Gabriella, Molinaro, Mario, Barton, Elisabeth R., L Sweeney, H., Rosenthal, Nadia·2001·Nature Genetics

DOI 10.1038/84839

Open this paper in CoChat — free account

Abstract

Aging skeletal muscles suffer a steady decline in mass and functional performance, and compromised muscle integrity as fibrotic invasions replace contractile tissue, accompanied by a characteristic loss in the fastest, most powerful muscle fibers. The same programmed deficits in muscle structure and function are found in numerous neurodegenerative syndromes and disease-related cachexia. We have generated a model of persistent, functional myocyte hypertrophy using a tissue-restricted transgene encoding a locally acting isoform of insulin-like growth factor-1 that is expressed in skeletal muscle (mIgf-1). Transgenic embryos developed normally, and postnatal increases in muscle mass and strength were not accompanied by the additional pathological changes seen in other Igf-1 transgenic models. Expression of GATA-2, a transcription factor normally undetected in skeletal muscle, marked hypertrophic myocytes that escaped age-related muscle atrophy and retained the proliferative response to muscle injury characteristic of younger animals. The preservation of muscle architecture and age-independent regenerative capacity through localized mIgf-1 transgene expression suggests clinical strategies for the treatment of age or disease-related muscle frailty.

Integrity signals

Registry

Crossref · 10.1038/84839

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
Molkentin, J. D., Lu, J., Antos, C. L., Markham, B. E., Richardson, J. A., Robbins, J. M., Grant, S. R., & Olson, E. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81573-1 · Cited by 2,566
Growth Hormone and the Insulin-Like Growth Factor System in Myogenesis*
Florini, J. R., Ewton, D. Z., & Coolican, S. A. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-5-481 · Cited by 1,148
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber typePreprint
Chin, E. R., Olson, E. N., Richardson, J. A., Yang, Q., Humphries, C. G., Shelton, J. M., Wu, H., Zhu, W., Bassel‐Duby, R., & Williams, R. S. (1998) · Genes & Development · doi:10.1101/gad.12.16.2499 · Cited by 1,015
Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice
Sjögren, K., Liu, J., Blad, K., Skrtic, S., Vidal, O., Wallenius, V., LeRoith, D., Törnell, J., Isaksson, O. G. P., Jansson, J., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.7088 · Cited by 940
Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors
Stewart, C. E., & Rotwein, P. S. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.4.1005 · Cited by 785
Contractile properties of skeletal muscles from young, adult and aged mice.
Brooks, S. V., & Faulkner, J. A. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017279 · Cited by 777
Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function
Barton-Davis, E. R., Shoturma, D. I., Musarò, A., Rosenthal, N. A., & Sweeney, H. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15603 · Cited by 700
Self-citation
IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1
Musarò, A., McCullagh, K. J. A., Naya, F. J., Olson, E. N., & Rosenthal, N. A. (1999) · Nature · doi:10.1038/23060 · Cited by 652
Self-citation
Myogenic Vector Expression of Insulin-like Growth Factor I Stimulates Muscle Cell Differentiation and Myofiber Hypertrophy in Transgenic Mice
Coleman, M. E., DeMayo, F., Yin, K. C., Lee, H. M., Geske, R., Montgomery, C., & Schwartz, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.20.12109 · Cited by 642
CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo
Passier, R., Zeng, H., Frey, N., Naya, F. J., Nicol, R. L., McKinsey, T. A., Overbeek, P. A., Richardson, J. A., Grant, S. R., & Olson, E. N. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8551 · Cited by 521

Flagged first, then by citations

Show all 30 references

Sorted by citations

Items 401–500 of 996

Suppression of body fat accumulation in myostatin-deficient mice
McPherron, A. C., & Lee, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200213562 · Cited by 55
Alteration of somatotropic function by proinflammatory cytokines.
Frost, R. A., & Lang, C. H. (2004) · PubMed · doi:10.2527/2004.8213_supple100x · Cited by 55
Muscular Dystrophy—Reason for Optimism?
Burton, E. A., & Davies, K. E. (2002) · Cell · doi:10.1016/s0092-8674(01)00626-2 · Cited by 55
Skeletal muscle fibres synthesis in heart failure: Role of PGC-1α, calcineurin and GH
Vescovo, G., Ravara, B., Gobbo, V., Angelini, A., & Libera, L. D. (2005) · International Journal of Cardiology · doi:10.1016/j.ijcard.2004.10.059 · Cited by 53
Local expression of mIgf-1 modulates ubiquitin, caspase and CDK5 expression in skeletal muscle of an ALS mouse model
Dobrowolny, G., Aucello, M., Molinaro, M., & Musarò, A. (2008) · Neurological Research · doi:10.1179/174313208x281235 · Cited by 54
Self-citation
Body composition and nutritional intake in children with chronic kidney disease
Rashid, R., Neill, E., Smith, W. A., King, D., Beattie, T. J., Murphy, A. V., Ramage, I. J., Maxwell, H., & Ahmed, S. F. (2006) · Pediatric Nephrology · doi:10.1007/s00467-006-0235-y · Cited by 54
Skeletal Muscle in Motor Neuron Diseases: Therapeutic Target and Delivery Route for Potential Treatments
Dupuis, L., & Echaniz‐Laguna, A. (2010) · Current Drug Targets · doi:10.2174/1389450111007011250 · Cited by 53
Dihydrotestosterone Ameliorates Degeneration in Muscle, Axons and Motoneurons and Improves Motor Function in Amyotrophic Lateral Sclerosis Model Mice
Yoo, Y.-E., & Ko, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037258 · Cited by 54
Dystrophin and utrophin expression require sarcospan: loss of α7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice
Marshall, J. L., Chou, E., Oh, J., Kwok, A., Burkin, D. J., & Crosbie, R. H. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds271 · Cited by 50
Effects of different types of exercise on skeletal muscle atrophy, antioxidant capacity and growth factors expression following myocardial infarction
Cai, M., Wang, Q., Liu, Z., Jia, D., Feng, R., & Tian, Z. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.10.015 · Cited by 53
The role of myostatin and the calcineurin-signalling pathway in regulating muscle mass in response to exercise training in the rainbow troutOncorhynchus mykissWalbaum
Martin, C. I., & Johnston, I. A. (2005) · Journal of Experimental Biology · doi:10.1242/jeb.01605 · Cited by 53
Are antioxidants useful for treating skeletal muscle atrophy?
Bonetto, A., Penna, F., Muscaritoli, M., Minero, V. G., Fanelli, F. R., Baccino, F. M., & Costelli, P. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.07.002 · Cited by 53
Cardiac Stem Cells Fail With Aging
Capogrossi, M. C. (2004) · Circulation Research · doi:10.1161/01.res.0000122070.37999.1b · Cited by 52
Correlation between insulin-like growth factor 1 gene expression and fennel (Foeniculum vulgare) seed powder consumption in muscle of sheep
Shahsavari, M., Mohammadabadi, M., Khezri, A., Fozi, M. A., Babenko, O., Калашник, О. М., Oleshko, V. P., & Tkachenko, S. V. (2021) · Animal Biotechnology · doi:10.1080/10495398.2021.2000997 · Cited by 51
Chimeric Adeno-Associated Virus/Antisense U1 Small Nuclear RNA Effectively Rescues Dystrophin Synthesis and Muscle Function by Local Treatment of mdx Mice
Denti, M. A., Rosa, A., D’Antona, G., Sthandier, O., Angelis, F. G. D., Nicoletti, C., Allocca, M., Pansarasa, O., Parente, V., Musarò, A., et al. (2006) · Human Gene Therapy · doi:10.1089/hum.2006.17.565 · Cited by 53
Self-citation
Insulin-like growth factor I slows the rate of denervation induced skeletal muscle atrophy
Shavlakadze, T., White, J. D., Davies, M. J., Hoh, J. F. Y., & Grounds, M. D. (2005) · Neuromuscular Disorders · doi:10.1016/j.nmd.2004.10.013 · Cited by 51
Modulation of Insulin-like Growth Factor (IGF)-I and IGF-Binding Protein Interactions Enhances Skeletal Muscle Regeneration and Ameliorates the Dystrophic Pathology in mdx Mice
Schertzer, J. D., Gehrig, S. M., Ryall, J. G., & Lynch, G. S. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.070292 · Cited by 51
Akt/mTOR pathway contributes to skeletal muscle anti-atrophic effect of aerobic exercise training in heart failure mice
Bacurau, A. V. N., Jannig, P. R., de Moraes, W. M. A. M., Cunha, T. F., Medeiros, A., Barberi, L., Coelho, M. A., Bacurau, R. F. P., Ugrinowitsch, C., Musarò, A., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.03.071 · Cited by 53
Self-citation
IGF1 stimulates greater muscle hypertrophy in the absence of myostatin in male mice
Hennebry, A., Oldham, J. M., Shavlakadze, T., Grounds, M. D., Sheard, P. W., Fiorotto, M. L., Falconer, S. J., Smith, H. K., Berry, C., Jeanplong, F., et al. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0032 · Cited by 53
Increasing Local Levels of IGF-I mRNA Expression Using Adenoviral Vectors Does Not Alter Oligodendrocyte Remyelination in the CNS of Aged Rats
O'Leary, M. T., Hinks, G. L., Charlton, H. M., & Franklin, R. J. M. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.1062 · Cited by 50
Myotonic Dystrophy: Therapeutic Strategies for the Future
Wheeler, T. M. (2008) · Neurotherapeutics · doi:10.1016/j.nurt.2008.08.001 · Cited by 53
PTEN controls β‐cell regeneration in aged mice by regulating cell cycle inhibitor p16 ink4a
Zeng, N., Yang, K., Bayan, J., He, L., Aggarwal, R., Stiles, J. W., Hou, X., Medina, V., Abad, D., Palian, B. M., et al. (2013) · Aging Cell · doi:10.1111/acel.12132 · Cited by 50
Insulin‐like growth factor binding protein 2 (IGFBP‐2) separates hypertrophic and hyperplastic effects of growth hormone (GH)/IGF‐I excess on adrenocortical cells in vivo
Hoeflich, A., Weber, M. M., Fisch, T., Nedbal, S., Fottner, C., Elmlinger, M. W., Wanke, R., & Wolf, E. (2002) · The FASEB Journal · doi:10.1096/fj.02-0349com · Cited by 48
Transplanted Mesoangioblasts Require Macrophage IL-10 for Survival in a Mouse Model of Muscle Injury
Bosurgi, L., Corna, G., Vezzoli, M., Touvier, T., Cossu, G., Manfredi, A. A., Brunelli, S., & Rovere, P. Q. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102680 · Cited by 54
The Orphan Nuclear Receptor Nur77 Is a Determinant of Myofiber Size and Muscle Mass in Mice
Tontonoz, P., Cortez-Toledo, O., Wroblewski, K., Hong, C., Lim, L., Carranza, R., Conneely, O. M., METZGER, D., & Chao, L. C. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00715-14 · Cited by 48
Grb10 regulates the development of fiber number in skeletal muscle
Holt, L. J., Turner, N. A., Mokbel, N., Trefely, S., Kanzleiter, T., Kaplan, W. H., Ormandy, C. J., Daly, R. J., & Cooney, G. J. (2012) · The FASEB Journal · doi:10.1096/fj.11-199349 · Cited by 49
Insulin-Like Growth Factor-I E-Peptide Activity Is Dependent on the IGF-I Receptor
Brisson, B. K., & Barton, E. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045588 · Cited by 48
Self-citation
The Insulin-like Growth Factor (IGF)-I E-Peptides Modulate Cell Entry of the Mature IGF-I Protein
Pfeffer, L. A., Brisson, B. K., Lei, H., & Barton, E. R. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1202 · Cited by 48
Self-citation
Molecular Insights into Muscle Homeostasis, Atrophy and Wasting
Scicchitano, B. M., Dobrowolny, G., Sica, G., & Musarò, A. (2018) · Current Genomics · doi:10.2174/1389202919666180101153911 · Cited by 52
Self-citation
Mechano-growth factor, an IGF-I splice variant, rescues motoneurons and improves muscle function in SOD1G93A mice
Riddoch‐Contreras, J., Yang, S., Dick, J. R. T., Goldspink, G., Orrell, R. W., & Greensmith, L. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.10.014 · Cited by 48
Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet
Jamieson, P. M., Cleasby, M. E., Kuperman, Y., Morton, N. M., Kelly, P. A. T., Brownstein, D. G., Mustard, K. J., Vaughan, J. M., Carter, R. N., HAHN, C. N., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2205-6 · Cited by 48
Skeletal muscle IGF-binding protein-3 and -5 expressions are age, muscle, and load dependent
Spangenburg, E. E., Abraha, T. W., Childs, T. E., Pattison, J. S., & Booth, F. W. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00253.2002 · Cited by 48
Insulin-like 6 Is Induced by Muscle Injury and Functions as a Regenerative Factor
Zeng, L., Akasaki, Y., Sato, K., Ouchi, N., Izumiya, Y., & Walsh, K. X. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.160879 · Cited by 49
Gene discovery by microarray: identification of novel genes induced during growth factor-mediated muscle cell survival and differentiation
Kuninger, D., Kuzmickas, R., Peng, B. W., Pintar, J. E., & Rotwein, P. S. (2004) · Genomics · doi:10.1016/j.ygeno.2004.07.013 · Cited by 47
The Splicing of the IGF-I Gene to Yield Different Muscle Growth Factors
Goldspink, G., & Yang, S. Y. (2004) · Advances in genetics · doi:10.1016/s0065-2660(04)52002-3 · Cited by 46
Systemic Insulin-like Growth Factor-1 Reverses Hypoalgesia and Improves Mobility in a Mouse Model of Diabetic Peripheral Neuropathy
Chu, Q., Moreland, R. J., Yew, N. S., Foley, J., Ziegler, R. J., & Scheule, R. K. (2008) · Molecular Therapy · doi:10.1038/mt.2008.115 · Cited by 47
Angiotensin II as candidate of cardiac cachexia
Delafontaine, P., & Akao, M. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000222103.29009.70 · Cited by 47
Absence of Nrf2 or Its Selective Overexpression in Neurons and Muscle Does Not Affect Survival in ALS-Linked Mutant hSOD1 Mouse Models
Vargas, M. R., Burton, N. C., Gan, L., Johnson, D. A., Schäfer, M., Werner, S., & Johnson, J. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056625 · Cited by 48
Stimulation of both estrogen and androgen receptors maintains skeletal muscle mass in gonadectomized male mice but mainly via different pathways
Svensson, J., Movérare‐Skrtic, S., Windahl, S. H., Swanson, C., & Sjögren, K. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0165 · Cited by 46
Molecular and biochemical regulation of skeletal muscle metabolism
Zumbaugh, M. D., Johnson, S., Shi, T. H., & Gerrard, D. E. (2022) · Journal of Animal Science · doi:10.1093/jas/skac035 · Cited by 56
Temperature, size and developmental plasticity in birds
Weeks, B. C., Klemz, M., Wada, H., Darling, R., Dias, T., O'Brien, B. K., Probst, C. M., Zhang, M., & Zímová, M. (2022) · Biology Letters · doi:10.1098/rsbl.2022.0357 · Cited by 45
Muscle aging and sarcopenia: The pathology, etiology, and most promising therapeutic targets
Grima-Terrén, M., Campanario, S., Ramírez‐Pardo, I., Cisneros, A., Hong, X., Perdiguero, E., Serrano, A. L., Isern, J., & Muñoz‐Cánoves, P. (2024) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2024.101319 · Cited by 52
Inhibitory effects of IL‐6 on IGF‐1 activity in skeletal myoblasts could be mediated by the activation of SOCS‐3
Al‐Shanti, N., & Stewart, C. E. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23420 · Cited by 47
Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor
Yasui, A., Nishizawa, H., Okuno, Y., Morita, K., Kobayashi, H., Kawai, K., Matsuda, M., Kishida, K., Kihara, S., Kamei, Y., et al. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.10.013 · Cited by 46
POINT: IGF IS THE MAJOR PHYSIOLOGICAL REGULATOR OF MUSCLE MASS
Stewart, C. E., & Pell, J. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01246.2009 · Cited by 45
Competitive binding of musclin to natriuretic peptide receptor 3 with atrial natriuretic peptide
Kita, S., Nishizawa, H., Okuno, Y., Tanaka, M., Yasui, A., Matsuda, M., Yamada, Y., & Shimomura, I. (2009) · Journal of Endocrinology · doi:10.1677/joe-08-0551 · Cited by 46
Muscle-specific overexpression of IGF-I improves E-C coupling in skeletal muscle fibers from dystrophic mdx mice
Schertzer, J. D., van der Poel, C., Shavlakadze, T., Grounds, M. D., & Lynch, G. S. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00399.2007 · Cited by 46
Muscle-specific expression of insulin-like growth factor 1 improves outcome in Lama2Dy-w mice, a model for congenital muscular dystrophy type 1A
Kumar, A., Yamauchi, J., Girgenrath, T., & Girgenrath, M. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr126 · Cited by 46
Directed Myogenic Differentiation of Human Induced Pluripotent Stem Cells
Shoji, E., Woltjen, K., & Sakurai, H. (2015) · Methods in molecular biology · doi:10.1007/7651_2015_257 · Cited by 44
The physiopathologic interplay between stem cells and tissue niche in muscle regeneration and the role of IL-6 on muscle homeostasis and diseases
Forcina, L., Miano, C., & Musarò, A. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.05.001 · Cited by 46
Self-citation
The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility
Kim, J., Grotegut, C. A., Wisler, J. W., Mao, L., Rosenberg, P. B., Rockman, H. A., & Lefkowitz, R. J. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920310117 · Cited by 46
Are insulin-like growth factor and its binding proteins 1 and 3 clinically useful as markers of malnutrition, sarcopenia and inflammation in end-stage renal disease?
Axelsson, J., Qureshi, A. R., Divino‐Filho, J. C., Barany, P. F., Heimbürger, O., Lindholm, B., & Stenvinkel, P. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602373 · Cited by 46
Andropause: A Quality-of-Life Issue in Older Males
Haren, M. T., Kim, M. J., Tariq, S. H., Wittert, G., & Morley, J. E. (2006) · Medical Clinics of North America · doi:10.1016/j.mcna.2006.06.001 · Cited by 49
Mechanisms of Skeletal Muscle Atrophy and Molecular Circuitry of Stem Cell Fate in Skeletal Muscle Regeneration and Aging
Bodine, S. C., Sinha, I., & Sweeney, H. L. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad023 · Cited by 47
Reversal of Muscle Atrophy by Zhimu-Huangbai Herb-Pair via Akt/mTOR/FoxO3 Signal Pathway in Streptozotocin-Induced Diabetic Mice
Zhang, J., Zhuang, P., Wang, Y., Song, L., Zhang, M., Lu, Z., Zhang, L., Wang, J., Alemu, P. N., Zhang, Y., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100918 · Cited by 50
Regulation of Myoblast Differentiation by the Nuclear Envelope Protein NET39
Liu, G., Guan, T., Datta, K., Coppinger, J. A., Yates, J. R., & Gerace, L. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00684-09 · Cited by 47
Research Resource: Hormones, Genes, and Athleticism: Effect of Androgens on the Avian Muscular Transcriptome
Fuxjager, M. J., Lee, J., Chan, T.-M., Bahn, J. H., Chew, J. G., Xiao, X. G., & Schlinger, B. A. (2016) · Molecular Endocrinology · doi:10.1210/me.2015-1270 · Cited by 44
Adult Stem Cells and Skeletal Muscle Regeneration
Costamagna, D., Berardi, E., Ceccarelli, G., & Sampaolesi, M. (2015) · Current Gene Therapy · doi:10.2174/1566523215666150630121024 · Cited by 46
It's not just about protein turnover: the role of ribosomal biogenesis and satellite cells in the regulation of skeletal muscle hypertrophy
Brook, M. S., Wilkinson, D. J., Smith, K., & Atherton, P. J. (2019) · European Journal of Sport Science · doi:10.1080/17461391.2019.1569726 · Cited by 47
Utrophin Up-Regulation by an Artificial Transcription Factor in Transgenic Mice
Mattei, E., Corbi, N., Certo, M. G. D., Strimpakos, G., Severini, C., Onori, A., Desantis, A., Libri, V., Buontempo, S., Floridi, A., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000774 · Cited by 45
Cellular and molecular pathways controlling muscle size in response to exercise
Attwaters, M., & Hughes, S. M. (2021) · FEBS Journal · doi:10.1111/febs.15820 · Cited by 47
Engineered insulin-like growth factor-1 for improved smooth muscle regeneration
Lorentz, K. M., Yang, L., Frey, P., & Hubbell, J. A. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.09.088 · Cited by 45
Controlled delivery of SDF-1α and IGF-1: CXCR4 + cell recruitment and functional skeletal muscle recovery
Rybalko, V., Pham, C. B., Hsieh, P., Hammers, D. W., Merscham‐Banda, M., Suggs, L. J., & Farrar, R. P. (2015) · Biomaterials Science · doi:10.1039/c5bm00233h · Cited by 44
Differential control of muscle mass in type 1 and type 2 diabetes mellitus
Sala, D., & Antonio Zorzano, A. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1954-7 · Cited by 45
Atomoxetine Prevents Dexamethasone-Induced Skeletal Muscle Atrophy in Mice
Jesinkey, S. R., Korrapati, M. C., Rasbach, K. A., Beeson, C., & Schnellmann, R. G. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.217380 · Cited by 48
Muscle strength in patients with acromegaly at diagnosis and during long-term follow-up
Füchtbauer, L. M., Olsson, D. S., Bengtsson, B., Norrman, L.-L., Sunnerhagen, K. S., & Johannsson, G. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0120 · Cited by 44
Insulin‐Like Growth Factor I Regulation and Its Actions in Skeletal Muscle
Vassilakos, G., & Barton, E. R. (2018) · Comprehensive physiology · doi:10.1002/cphy.c180010 · Cited by 48
Self-citation
Supplementation of Magnolol Attenuates Skeletal Muscle Atrophy in Bladder Cancer-Bearing Mice Undergoing Chemotherapy via Suppression of FoxO3 Activation and Induction of IGF-1
Chen, M.-C., Chen, Y.-L., Lee, C.-F., Hung, C.-H., & Chou, T.-C. (2015) · PLOS ONE · doi:10.1371/journal.pone.0143594 · Cited by 45
Mammalian Mss51 is a Skeletal Muscle-Specific Gene Modulating Cellular Metabolism
Moyer, A. L., & Wagner, K. R. (2015) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-150119 · Cited by 43
Signaling pathways mediating the effects of insulin-like growth factor-I in bovine muscle satellite cells
Ge, X., Zhang, Y., & Jiang, H. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.03.017 · Cited by 42
Loss of Emerin Alters Myogenic Signaling and miRNA Expression in Mouse Myogenic Progenitors
Koch, A. J., & Holaska, J. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037262 · Cited by 43
Mechanosensitive Molecular Networks Involved in Transducing Resistance Exercise-Signals into Muscle Protein Accretion
Rindom, E., & Vissing, K. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00547 · Cited by 44
Therapy of muscle wasting in cancer: what is the future?
Muscaritoli, M., Bossola, M., Bellantone, R. D. A., & Fanelli, F. R. (2004) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000134366.07148.2e · Cited by 43
Left ventricular assist device-induced molecular changes in the failing myocardium
Soppa, G. K. R., Barton, P. J. R., Terracciano, C. M., & Yacoub, M. H. (2008) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e3282fc7010 · Cited by 42
Cell-autonomous and non-cell-autonomous toxicity in polyglutamine diseases
Sambataro, F., & Pennuto, M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.10.003 · Cited by 45
NET37, a Nuclear Envelope Transmembrane Protein with Glycosidase Homology, Is Involved in Myoblast Differentiation
Datta, K., Guan, T., & Gerace, L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.034041 · Cited by 45
Emerging drugs for sarcopenia: age-related muscle wasting
Lynch, G. S. (2004) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.9.2.345 · Cited by 45
Mitochondrial glycerol 3‐phosphate dehydrogenase promotes skeletal muscle regeneration
Liu, X., Qu, H., Zheng, Y., Liao, Q., Zhang, L., Liao, X., Xiong, X., Wang, Y., Zhang, R., Wang, H., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201809390 · Cited by 40
Disparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function
Pharaoh, G. A., Owen, D. B., Yeganeh, A., Premkumar, P., Farley, J. A., Bhaskaran, S., Ashpole, N. M., Kinter, M. T., Remmen, H. V., & Logan, S. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01821-4 · Cited by 44
The neuroprotective effects of a locally acting IGF-1 isoform
Musarò, A., Dobrowolny, G., & Rosenthal, N. A. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.05.004 · Cited by 41
Self-citation
Impaired overload-induced hypertrophy in obese Zucker rat slow-twitch skeletal muscle
Paturi, S., Gutta, A. K., Kakarla, S. K., Katta, A., Arnold, E. C., Wu, M., Rice, K. M., & Blough, E. R. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00330.2009 · Cited by 42
Dietary Supplementation with α-Ketoglutarate Activates mTOR Signaling and Enhances Energy Status in Skeletal Muscle of Lipopolysaccharide-Challenged Piglets
Wang, L., Yi, D., Hou, Y., Ding, B., Li, K., Li, B., Zhu, H., Liu, Y., & Wu, G. (2016) · Journal of Nutrition · doi:10.3945/jn.116.236000 · Cited by 41
Different Effects of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-2 on Myogenic Differentiation of Human Mesenchymal Stem Cells
Aboalola, D. A., & Han, V. K. M. (2017) · Stem Cells International · doi:10.1155/2017/8286248 · Cited by 41
Blockade of IGF2R improves muscle regeneration and ameliorates Duchenne muscular dystrophy
Bella, P., Farini, A., Banfi, S., Parolini, D., Tonna, N., Meregalli, M., Belicchi, M., Erratico, S., D’Ursi, P., Bianco, F., et al. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201911019 · Cited by 41
Skeletal muscle regeneration in mice is stimulated by local overexpression of V1a-vasopressin receptor
Toschi, A., Severi, A., Coletti, D., Catizone, A., Musarò, A., Molinaro, M., Nervi, C., Adamo, S., & Scicchitano, B. M. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-1049 · Cited by 39
Self-citation
The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy
Graça, F. A., Rai, M., Hunt, L. C., Stephan, A., Wang, Y., Gordon, B., Wang, R., Quarato, G., Xu, B., Fan, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30120-1 · Cited by 41
Gene expression in skeletal muscle of coronary artery disease patients after concentric and eccentric endurance training
Zoll, J., Steiner, R., Meyer, K., Vogt, M., Hoppeler, H., & Flück, M. (2005) · European Journal of Applied Physiology · doi:10.1007/s00421-005-0082-8 · Cited by 40
Deletion of muscle IGF‐I transiently impairs growth and progressively disrupts glucose homeostasis in male mice
Vassilakos, G., Lei, H., Yang, Y., Puglise, J. M., Matheny, M. E., Durzyńska, J., Ozery, M., Bennett, K., Spradlin, R. A., Bonanno, H., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201800459r · Cited by 40
Self-citation
Measuring Mechanical Properties, Including Isotonic Fatigue, of Fast and Slow MLC/mIgf-1 Transgenic Skeletal Muscle
Prete, Z. D., Musarò, A., & Rizzuto, E. (2008) · Annals of Biomedical Engineering · doi:10.1007/s10439-008-9496-x · Cited by 40
Self-citation
Skeletal Muscle as a Mediator of Interorgan Crosstalk During Exercise: Implications for Aging and Obesity
Shero, J. A., Lindholm, M. E., Sandri, M. F., & Stanford, K. I. (2025) · Circulation Research · doi:10.1161/circresaha.124.325614 · Cited by 45
Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response
Eletto, D., Maganty, A., Eletto, D., Dersh, D., Makarewich, C. A., Biswas, C., Paton, J. C., Paton, A. W., Doroudgar, S., Glembotski, C. C., et al. (2012) · Journal of Cell Science · doi:10.1242/jcs.108928 · Cited by 39
Validated treatments and therapeutics prospectives regarding pharmacological products for sarcopenia
Onder, G., Vedova, C. D., & Landi, F. (2009) · The journal of nutrition health & aging · doi:10.1007/s12603-009-0209-4 · Cited by 39
Glucose regulated protein 94 is required for muscle differentiation through its control of the autocrine production of insulin-like growth factors
Ostrovsky, O., Eletto, D., Makarewich, C., Barton, E. R., & Argon, Y. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.11.005 · Cited by 36
Self-citation
Effects of electrical stimulation and stretching on the adaptation of denervated skeletal muscle: implications for physical therapy
Salvini, T. F., Durigan, J. L. Q., Peviani, S. M., & Russo, T. L. (2012) · Brazilian Journal of Physical Therapy · doi:10.1590/s1413-35552012005000027 · Cited by 39
Cell Size Control
Guertin, D. A., & Sabatini, D. M. (2006) · Encyclopedia of Life Sciences · doi:10.1038/npg.els.0003359 · Cited by 39
Maintaining skeletal muscle mass: lessons learned from hibernation
Ivakine, E. A., & Cohn, R. D. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2013.074344 · Cited by 39
Role of IGF-I in follistatin-induced skeletal muscle hypertrophy
Barbé, C., Kalista, S., Loumaye, A., Ritvos, O., Lause, P., Ferracin, B., & Thissen, J. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00098.2015 · Cited by 40
Coffee consumption promotes skeletal muscle hypertrophy and myoblast differentiation
Jang, Y. J., Son, H. J., Kim, J., Jung, C. H., Ahn, J., Hur, J., & Ha, T. Y. (2018) · Food & Function · doi:10.1039/c7fo01683b · Cited by 39
Effects of Soy Foods in Postmenopausal Women: A Focus on Osteosarcopenia and Obesity
Tang, S., Du, Y., Oh, C., & No, J.-K. (2020) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes20006 · Cited by 39
ANABOLIC AGENTS FOR IMPROVING MUSCLE REGENERATION AND FUNCTION AFTER INJURY
Lynch, G. S., Schertzer, J. D., & Ryall, J. G. (2008) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2008.04955.x · Cited by 38

Authors: Musarò, A., McCullagh, K., Paul, A., Houghton, L., Dobrowolny, G., Molinaro, M., Barton, E. R., L Sweeney, H., & Rosenthal, N.
Affiliations: Massachusetts General Hospital (US)
Sapienza University of Rome (IT)
University of Pennsylvania (US)
Corresponding author: Rosenthal, Nadia
ORCID: Musarò, Antonio
McCullagh, Karl
Paul, Angelika
Dobrowolny, Gabriella
Barton, Elisabeth R.
Rosenthal, Nadia
Venue: Nature Genetics
Publisher: Springer Science and Business Media LLC
Published: 2001-02
Volume: 27
Issue: 2
Pages: 195-200
ISSN: 1061-4036 (ISSN-L)
1546-1718
DOI: 10.1038/84839
OpenAlex: W1562705858
Cited by: 1,137
References: 30
Citations by year: 2026: 17 · 2025: 19 · 2024: 27 · 2023: 22 · 2022: 21 · 2021: 27 · 2020: 29 · 2019: 35 · 2018: 38 · 2017: 28 · 2016: 34 · 2015: 60 · 2014: 52 · 2013: 59 · 2012: 71
FWCI: 17.57
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Genetics (publishedVersion)
PubMed (publishedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Genetics (clinical) › Neurogenetic and Muscular Disorders Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
Keywords: insulin-like growth factor I, skeletal muscle aging, muscle atrophy, myocyte hypertrophy, muscle regeneration, muscle fibrosis, GATA2, transgenic mouse model, muscle strength
MeSH terms: Animals, Cachexia, DNA-Binding Proteins, Hypertrophy, Insulin-Like Growth Factor I, Mice, Transgenic, Organ Size, Regeneration, Tissue Distribution, Transcription Factors, Cellular Senescence, Muscle, Skeletal, Neurodegenerative Diseases, Protein Isoforms, GATA2 Transcription Factor, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks