The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle
Abstract
Aging skeletal muscles suffer a steady decline in mass and functional performance, and compromised muscle integrity as fibrotic invasions replace contractile tissue, accompanied by a characteristic loss in the fastest, most powerful muscle fibers. The same programmed deficits in muscle structure and function are found in numerous neurodegenerative syndromes and disease-related cachexia. We have generated a model of persistent, functional myocyte hypertrophy using a tissue-restricted transgene encoding a locally acting isoform of insulin-like growth factor-1 that is expressed in skeletal muscle (mIgf-1). Transgenic embryos developed normally, and postnatal increases in muscle mass and strength were not accompanied by the additional pathological changes seen in other Igf-1 transgenic models. Expression of GATA-2, a transcription factor normally undetected in skeletal muscle, marked hypertrophic myocytes that escaped age-related muscle atrophy and retained the proliferative response to muscle injury characteristic of younger animals. The preservation of muscle architecture and age-independent regenerative capacity through localized mIgf-1 transgene expression suggests clinical strategies for the treatment of age or disease-related muscle frailty.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Muscle-specific overexpression of a locally acting IGF1 isoform in mice showed that localized IGF1 expression sustains muscle growth and regeneration6.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [6]
Citations
Cites
A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
Molkentin, J. D., Lu, J., Antos, C. L., Markham, B. E., Richardson, J. A., Robbins, J. M., Grant, S. R., & Olson, E. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81573-1 · Cited by 2,566
Growth Hormone and the Insulin-Like Growth Factor System in Myogenesis*
Florini, J. R., Ewton, D. Z., & Coolican, S. A. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-5-481 · Cited by 1,148
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber typePreprint
Chin, E. R., Olson, E. N., Richardson, J. A., Yang, Q., Humphries, C. G., Shelton, J. M., Wu, H., Zhu, W., Bassel‐Duby, R., & Williams, R. S. (1998) · Genes & Development · doi:10.1101/gad.12.16.2499 · Cited by 1,015
Sjögren, K., Liu, J., Blad, K., Skrtic, S., Vidal, O., Wallenius, V., LeRoith, D., Törnell, J., Isaksson, O. G. P., Jansson, J., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.7088 · Cited by 940
Stewart, C. E., & Rotwein, P. S. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.4.1005 · Cited by 785
Contractile properties of skeletal muscles from young, adult and aged mice.
Brooks, S. V., & Faulkner, J. A. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017279 · Cited by 777
Barton-Davis, E. R., Shoturma, D. I., Musarò, A., Rosenthal, N. A., & Sweeney, H. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15603 · Cited by 700
Self-citationMusarò, A., McCullagh, K. J. A., Naya, F. J., Olson, E. N., & Rosenthal, N. A. (1999) · Nature · doi:10.1038/23060 · Cited by 652
Self-citationColeman, M. E., DeMayo, F., Yin, K. C., Lee, H. M., Geske, R., Montgomery, C., & Schwartz, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.20.12109 · Cited by 642
CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo
Passier, R., Zeng, H., Frey, N., Naya, F. J., Nicol, R. L., McKinsey, T. A., Overbeek, P. A., Richardson, J. A., Grant, S. R., & Olson, E. N. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8551 · Cited by 521
Flagged first, then by citations
Cited by
Sorted by citations
Items 701–800 of 996
Jiang, X., Edström, E., Altun, M., & Ulfhake, B. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00030.x · Cited by 16
Gallego-Colón, E., Villalba‐Orero, M., Tonkin, J. N., Cruz, F. M., Bernal, J. A., Jimenez-Borregureo, L. J., Schneider, M. D., Lara‐Pezzi, E., & Rosenthal, N. A. (2016) · npj Regenerative Medicine · doi:10.1038/npjregenmed.2016.1 · Cited by 15
Self-citationImprovement of Eye Alignment in Adult Strabismic Monkeys by Sustained IGF-1 Treatment
McLoon, L., Christiansen, S., Ghose, G. M., Das, V., & Mustari, M. J. (2016) · Investigative Ophthalmology and Visual Science · doi:10.1167/iovs.16-19739 · Cited by 14
Site-Specific Conjugated Insulin-like Growth Factor-I for Anabolic Therapy
Wu, F., Braun, A. C., Lühmann, T. C., & Meinel, L. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b01016 · Cited by 15
Extraocular muscle regeneration in zebrafish requires late signals from Insulin-like growth factors
Saera-Vila, A., Louie, K. W., Sha, C., Kelly, R. M., Kish, P. E., & Kahana, A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192214 · Cited by 17
Pharmacology of doping agents—mechanisms promoting muscle hypertrophy
Parr, M. K., & Laughlin, A. M. M. (2018) · AIMS molecular science · doi:10.3934/molsci.2018.2.131 · Cited by 14
Muta, Y., Tanaka, T., Hamaguchi, Y., Hamanoue, N., Motonaga, R., Tanabe, M., Nomiyama, T., Nawata, H., & Yanase, T. (2019) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2019.01.006 · Cited by 15
The cytosolic sialidase Neu2 is degraded by autophagy during myoblast atrophy
Rossi, S., Stoppani, E., Martinet, W., Bonetto, A., Costelli, P., Giuliani, R., Colombo, F., Preti, A., Marchesini, S., & Fanzani, A. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.04.006 · Cited by 15
Hypertrophy and atrophy inversely regulate Caveolin-3 expression in myoblasts
Fanzani, A., Musarò, A., Stoppani, E., Giuliani, R., Colombo, F., Preti, A., & Marchesini, S. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.03.148 · Cited by 15
Self-citationThe stress reaction and its molecular events: splicing variants
Tang, L., Wang, Y., & Sun, C. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.167 · Cited by 15
Molecular Biology of ACL Graft Healing: Early Mechanical Loading Perspective.
Stańczak, M., & Kacprzak, B. (2025) · Orthopedic Reviews · doi:10.52965/001c.140716 · Cited by 16
Locomotor and respiratory muscle abnormalities in HFrEF and HFpEF
Mangner, N., Winzer, E. B., Linke, A. H.-P., & Adams, V. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1149065 · Cited by 14
Neural stimulation suppresses mTORC1-mediated protein synthesis in skeletal muscle
Dumitras, A. G., Piccoli, G., Tellkamp, F., Keufgens, L., Baraldo, M., Zorzato, S., Cussonneau, L., Nogara, L., Krüger, M., & Blaauw, B. (2025) · Science Advances · doi:10.1126/sciadv.adt4955 · Cited by 15
The effects of testosterone and insulin-like growth factor 1 on motor system form and function
Oki, K., Law, T., Loucks, A. B., & Clark, B. C. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.02.005 · Cited by 14
Martin, C. I., & Johnston, I. A. (2005) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2005.08.004 · Cited by 14
Barker, T., Leonard, S. W., Trawick, R. H., Walker, J. A., & Traber, M. G. (2009) · Redox Report · doi:10.1179/135100009x12525712409535 · Cited by 14
Sun, K.-T., Cheung, K., Au, S. W., Yeung, S. S., & Yeung, E. W. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00999 · Cited by 14
Jiménez-Moreno, R., Messi, M. L., Zheng, Z., Wang, Z., Ye, P., D’Ercole, J. A., & Delbono, O. (2006) · The Journal of Membrane Biology · doi:10.1007/s00232-006-0044-z · Cited by 14
Homer 2 antagonizes protein degradation in slow-twitch skeletal muscles
Bortoloso, E., Megighian, A., Furlan, S., Gorza, L., & Pompeo Volpe, D. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00108.2012 · Cited by 14
Novel therapies for sarcopenia: ameliorating age-related changes in skeletal muscle
Lynch, G. S. (2002) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.12.1.11 · Cited by 14
Vargas, M. R., Burton, N. C., Gan, L., Johnson, D. A., Schäfer, M., Werner, S., & Johnson, J. A. (2013) · PLoS ONE · doi:10.1371/annotation/28f68b10-e23d-4519-8d52-8cc94fe372b1 · Cited by 14
Kravchenko, I. V., Furalyov, V. A., & Popov, V. O. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-1187-5 · Cited by 13
Heparan sulfate controls skeletal muscle differentiation and motor functions
Yokoyama, M., Matsuzawa, T., Yoshikawa, T., Nunomiya, A., Yamaguchi, Y., & Yanai, K. (2020) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129707 · Cited by 13
Park7 Expression Influences Myotube Size and Myosin Expression in Muscle
Yu, H. M., Waddell, J. N., Kuang, S., & Bidwell, C. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092030 · Cited by 13
Welch, C. M., Thornton, K. J., Murdoch, G. K., Chapalamadugu, K. C., Schneider, C. S., Ahola, J. K., Hall, J. B., Price, W. J., & Hill, R. A. (2013) · Journal of Animal Science · doi:10.2527/jas.2013-6609 · Cited by 13
Transgenic Mice Expressing an Artificial Zinc Finger Regulator Targeting an Endogenous Gene
Passananti, C., Corbi, N., Onori, A., Certo, M. G. D., & Mattei, E. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-753-2_11 · Cited by 13
An Emerging Therapeutic Approach by Targeting Myoferlin (MYOF) for Malignant Tumors
Gu, H., Peng, Y., & Chen, Y. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200618123436 · Cited by 13
Innovative Strategies for Treatment of Soft Tissue Injuries in Human and Animal Athletes
Hoffmann, A., & Groß, G. (2009) · Medicine and sport science/Medicine and sport · doi:10.1159/000235702 · Cited by 13
Growth Factors, Muscle Function, and Doping
Goldspink, G., Wessner, B., Tschan, H., & Bachl, N. (2010) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2009.11.001 · Cited by 13
Onder, G., Liperoti, R., Russo, A., Capoluongo, E., Minucci, A., Lulli, P., Cesari, M., Maggio, M. G., Bernabei, R., & Landi, F. (2007) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-007-0262-z · Cited by 13
Ridgley, J. A., Pinniger, G. J., HAMER, P. W., & Grounds, M. D. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0568-4 · Cited by 13
Polymorphism of Insulin-Like Growth Factor I Gene among Chicken Breeds in Egypt
Gouda, E. M., & Essawy, G. S. (2010) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2010-3-418 · Cited by 13
Therapeutic Interventions for Age-related Muscle Wasting
Shavlakadze, T., & Grounds, M. D. (2003) · Springer eBooks · doi:10.1007/978-94-017-0283-6_9 · Cited by 22
Sports and exercise medicine—specialists or snake oil salesmen?
Franklyn‐Miller, A., Etherington, J., & McCrory, P. R. (2009) · British Journal of Sports Medicine · doi:10.1136/bjsm.2009.068999 · Cited by 13
Nutritional approaches targeting mitochondria for the prevention of sarcopenia
Hahm, J., Nirmala, F. S., Ha, T. Y., & Ahn, J. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad084 · Cited by 13
Gene therapy in monogenic congenital myopathies
Guan, X., Goddard, M. A., Mack, D. L., & Childers, M. K. (2015) · Methods · doi:10.1016/j.ymeth.2015.10.004 · Cited by 13
Chen, Z., Nilsson, E. D., Lindholm, B., Heimbürger, O., Barany, P. F., Stenvinkel, P., Qureshi, A. R., & Chen, J. (2022) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2022.06.008 · Cited by 12
The injury-induced myokine insulin-like 6 is protective in experimental autoimmune myositis
Zeng, L., Maruyama, S., Nakamura, K., Parker, J., Adham, I. M., Zhong, X., Lee, H., Querfurth, H. W., & Walsh, K. (2014) · Skeletal Muscle · doi:10.1186/2044-5040-4-16 · Cited by 12
Metabolic and Molecular Aspects of Sarcopenia
Cade, W. T., & Yarasheski, K. E. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-963-9_50 · Cited by 12
Gene Doping: Possibilities and Practicalities
Wells, D. J. (2009) · Medicine and sport science/Medicine and sport · doi:10.1159/000235703 · Cited by 12
Genética, performance física humana e doping genético: o senso comum versus a realidade científica
Dias, R. G. (2011) · Revista Brasileira de Medicina do Esporte · doi:10.1590/s1517-86922011000100012 · Cited by 15
Clenbuterol increases muscle fiber size and GATA‐2 protein in rat skeletal muscle in utero
Downie, D. A. W., Delday, M. I., Maltin, C. A., & Sneddon, A. A. (2007) · Molecular Reproduction and Development · doi:10.1002/mrd.20795 · Cited by 12
Senesi, P., Luzi, L., Montesano, A., & Terruzzi, I. (2013) · Endocrine · doi:10.1007/s12020-013-0142-5 · Cited by 14
Meyer, G. A., & Ward, S. R. (2016) · Physical Therapy · doi:10.2522/ptj.20150029 · Cited by 13
α CAR IGF ‐1 vector targeting of motor neurons ameliorates disease progression in ALS mice
Eleftheriadou, I., Manolaras, I., Irvine, E. E., Dieringer, M., Trabalza, A., & Mazarakis, N. D. (2016) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.335 · Cited by 12
Clark, R., Schuenke, M. D., Keeton, S. M., Staron, R. S., & Kopchick, J. J. (2006) · Hormone Research in Paediatrics · doi:10.1159/000096620 · Cited by 13
Free Radicals, Cytokines, and Respiratory Muscles in COPD Patients
Gea, J., Barreiro, E., & Orozco‐Levi, M. (2007) · Clinical Pulmonary Medicine · doi:10.1097/cpm.0b013e3180575dcd · Cited by 12
Dadon-Nachum, M., Ben‐Zur, T., Srugo, I., Shamir, H. M., Melamed, E., Yaffe, D., & Offen, D. (2012) · Europe PMC (PubMed Central) · Cited by 11
Anioke, I. C., Okwuosa, C. N., Uchendu, I. K., Chijioke, U. O., Dozie-Nwakile, O. C., Ikegwuonu, I. C., Kalu, P. N., & Okafor, M. J. (2017) · BioMed Research International · doi:10.1155/2017/6923629 · Cited by 11
Kim, S.-Y., Kim, H.-S., Cho, M., & Jeon, Y. (2019) · Journal of Aquatic Food Product Technology · doi:10.1080/10498850.2019.1575940 · Cited by 11
Excitation-Contraction Coupling Regulation in Aging Skeletal Muscle
Delbono, O. (2010) · Springer eBooks · doi:10.1007/978-90-481-9713-2_6 · Cited by 12
Developmental regulation of molecular signalling in fetal and neonatal diaphragm protein metabolism
Song, Y., & Pillow, J. J. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370213494562 · Cited by 12
Proliferation of Multiple Cell Types in the Skeletal Muscle Tissue Elicited by Acute p21 Suppression
Biferi, M. G., Nicoletti, C., Falcone, G., Puggioni, E. M. R., Passaro, N., Mazzola, A., Pajalunga, D., Zaccagnini, G., Rizzuto, E., Auricchio, A., et al. (2015) · Molecular Therapy · doi:10.1038/mt.2015.27 · Cited by 11
Self-citationModeling Energy Dynamics in Mice with Skeletal Muscle Hypertrophy Fed High Calorie Diets
Bond, N. D., Guo, J., Hall, K. D., & McPherron, A. C. (2016) · International Journal of Biological Sciences · doi:10.7150/ijbs.13525 · Cited by 10
The Etiology and Impact of Muscle Wasting in Metastatic CancerPreprint
Biswas, A., & Acharyya, S. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a037416 · Cited by 11
The effect of exercise on IGF-I on muscle fibers and satellite cells
Shefer, G. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/372 · Cited by 10
Gene doping: Olympic genes for Olympic dreams
Battery, L., Solomon, A., & Gould, D. (2011) · Journal of the Royal Society of Medicine · doi:10.1258/jrsm.2011.110240 · Cited by 10
Wang, H., Li, X., Liu, H., Sun, L., Zhang, R., Li, L., Wangding, M., & Wang, J. (2016) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2015-0075 · Cited by 11
Coelho, P. D. O., Guarnier, F. A., Figueiredo, L. B., Zaramela, L. S., Pacini, E. S. A., Godinho, R. O., & Gomes, M. D. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.01.009 · Cited by 10
Faster and Healthier: Relationship between Telomere and Performance in Master Athletes
Sousa, C. V., Aguiar, S. D. S., Deus, L. A., Barbosa, L. P., Santos, P. A., Neves, R. V. P., Maciel, L. A., Moraes, M. R., Moreira, S. R., Campbell, C. S. G., et al. (2020) · International Journal of Sports Medicine · doi:10.1055/a-1088-5279 · Cited by 10
Beef extract supplementation promotes myoblast proliferation and myotube growth in C2C12 cells
Sawano, S., Baba, K., Sonoda, Y., Wakamatsu, J., Tomonaga, S., Furuse, M., Sato, Y., Tatsumi, R., Ikeuchi, Y., & Mizunoya, W. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02205-4 · Cited by 10
Pulmonary Rehabilitation Programs
Ambrosino, N. (2002) · Disease Management & Health Outcomes · doi:10.2165/00115677-200210090-00002 · Cited by 9
Exercise and Health: Can Biotechnology Confer Similar Benefits?
Williams, R. S., & Kraus, W. E. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020068 · Cited by 10
Sarcopenia: characteristics, genesis, remedies
Tano, G. D., Fulle, S., Pietrangelo, T., Bellomo, R. G., & Fanò, G. (2005) · Sport Sciences for Health · doi:10.1007/s11332-2005-004-0013-4 · Cited by 10
Insulin-like Growth Factor I and Insulin and Their Abuse in Sport
Erotokritou‐Mulligan, I., & Holt, R. I. G. (2010) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2009.10.003 · Cited by 10
GATA elements control repression of cardiac troponin I promoter activity in skeletal muscle cells
Lisi, R. D., Picard, A., Ausoni, S., & Schiaffino, S. (2007) · BMC Molecular Biology · doi:10.1186/1471-2199-8-78 · Cited by 10
Electrochemical Synthesis of Selenocarbonates
Groia, A. L., Feroci, M., Inesi, A., & Rossi, L. (2006) · Letters in Organic Chemistry · doi:10.2174/157017806779117003 · Cited by 10
Lee, E. H., & Neppl, R. L. (2021) · Genes · doi:10.3390/genes12050688 · Cited by 11
The Critical Role of Insulin-Like Growth Factor-1 Isoforms in the Physiopathology of Skeletal Muscle
Musarò, A., & Rosenthal, N. A. (2006) · Current Genomics · doi:10.2174/138920206776389784 · Cited by 10
Self-citationModulations of the calcineurin/NF-AT pathway in skeletal muscle atrophy
Costelli, P., Almendro, V., Figueras, M. T., Reffo, P., Penna, F., Aragno, M., Mastrocola, R., Boccuzzi, G., Busquets, S., Bonelli, G., et al. (2007) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2007.03.003 · Cited by 10
Dennehey, B. K., Leinwand, L. A., & Krauter, K. S. (2006) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-006-9071-8 · Cited by 10
Overview and Molecular Aspects of the Insulin-Like Growth Factor System
Adamo, M. L., Wang, L., Héron‐Milhavet, L., Ben‐Yosef, D., Zhao, H., & Roith, D. L. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-795-6_1 · Cited by 10
Grzelkowska‐Kowalczyk, K., & Wieteska‐Skrzeczyńska, W. (2006) · PubMed · Cited by 10
Targeting IGF1 to alleviate obesity through regulating energy expenditure and fat deposition
Rong, P., Mu, Y., Wang, M., Chen, L., Liu, F., Jin, Y., Feng, W., Zhou, K., Liang, H., Wang, H., et al. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2768-y · Cited by 10
Xia, H., Zhang, B., Yang, D., Zhu, C., Zhang, J., Chen, H., Ma, H., Hu, S., Xu, C., Shi, C., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.624303 · Cited by 9
Pelosi, M., Alfò, M., Martella, F., Pappalardo, E., & Musarò, A. (2015) · BMC Bioinformatics · doi:10.1186/s12859-015-0689-7 · Cited by 9
Self-citationLatest developments in engineered skeletal muscle tissues for drug discovery and development
Ostrovidov, S., Ramalingam, M., Bae, H., Orive, G., Fujie, T., Shi, X., & Kaji, H. (2022) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2023.2160438 · Cited by 9
Rae, F., Suhaimi, N., Li, J., Nastasi, T., Slonimsky, E., Rosenthal, N. A., & Little, M. H. (2011) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2011.11.002 · Cited by 9
Self-citationInduction of insulin-like growth factor 1 splice forms by subfragments of myofibrillar proteins
Kravchenko, I. V., Furalyov, V. A., Chatziefthimiou, S. D., Wilmanns, M., & Popov, V. O. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.08.010 · Cited by 9
Eley, H., Russell, S., & Tisdale, M. J. (2008) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-9742-4 · Cited by 13
Muscle Involvement and IGF-1 Signaling in Genetic Disorders: New Therapeutic Approaches
Barberi, L., Dobrowolny, G., Pelosi, L., Giacinti, C., & Musarò, A. (2009) · Endocrine development · doi:10.1159/000207474 · Cited by 9
Self-citationFibro-Adipogenic Progenitors require autocrine IGF-I in homeostatic and regenerating skeletal musclePreprint
Luo, Y. E., Abe-Teh, Z., Alsaghir, T. Y., Kuo, L.-Y., Yu, F., Stoker, B. E., Appu, A. B., Zhou, Y., Yue, F., Kopinke, D., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.11.648330 · Cited by 9
Self-citationSam68 splicing regulation contributes to motor unit establishment in the postnatal skeletal muscle
Paola, E. D., Forcina, L., Pelosi, L., Pisu, S., Rosa, P. L., Cesari, E., Nicoletti, C., Madaro, L., Mercatelli, N., Biamonte, F., et al. (2020) · Life Science Alliance · doi:10.26508/lsa.201900637 · Cited by 9
Self-citationRegulation of muscle stem cell function
von Maltzahn, J. (2021) · Vitamins and hormones · doi:10.1016/bs.vh.2021.02.012 · Cited by 9
Montoya, B., Tóth, Z., Lendvai, Á. Z., Stier, A., Criscuolo, F., Zahn, S., & Bize, P. (2022) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2022.853674 · Cited by 8
Aoi, W., Iwasa, M., Aiso, C., Tabata, Y., Gotoh, Y., Kosaka, H., & Suzuki, T. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.04.097 · Cited by 8
Role of IGF-1 in Age-Related Loss of Skeletal Muscle Mass and Function
McMahon, C. D., Shavlakadze, T., & Grounds, M. D. (2010) · Springer eBooks · doi:10.1007/978-90-481-9713-2_17 · Cited by 8
The quasi-parallel lives of satellite cells and atrophying muscle
Biressi, S. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00140 · Cited by 9
IGF-1 Antibody Prolongs the Effective Duration Time of Botulinum Toxin in Decreasing Muscle Strength
Jin, L., Pan, L., Liu, W., Guo, Y., Zheng, Y., Guan, Q., & Nie, Z. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14059051 · Cited by 8
Autologous Growth Factors: A Biological Treatment in Sports Medicine
Leong, D., Benedict, B. C. T., & Chew, K. T. L. (2010) · Proceedings of Singapore Healthcare · doi:10.1177/201010581001900309 · Cited by 8
Fernandez, A. M., & LeRoith, D. (2005) · Springer eBooks · doi:10.1007/0-387-26274-1_5 · Cited by 8
RNA signaling in skeletal muscle: the central role of microRNAs and exosomal microRNAs
Liu, S., & Dong, H. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1639123 · Cited by 10
Older postmenopausal women with lower lean mass have hypermethylated sites in the PI3K-Akt pathway
Correia, I. M., Rodrigues, G. D. S., Noronha, N., Watanabe, L. M., de Almeida, M. L., Sobrinho, A. C. D. S., Nonino, C., & Bueno, C. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1150821 · Cited by 5
Zhang, B., Xian, C., Luo, Y., & Wang, Y. (2009) · Science in China Series C Life Sciences · doi:10.1007/s11427-009-0122-4 · Cited by 7
Putarjunan, A., & Torii, K. U. (2016) · Development Growth & Differentiation · doi:10.1111/dgd.12282 · Cited by 7
IGF-1 knockdown inhibits phosphorylation of Akt and ERK in chicken embryonic myotubes
Saneyasu, T., Nakamura, T., Honda, K., & Kamisoyama, H. (2022) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2022.101478 · Cited by 7
Elbialy, Z. I., Atef, E., Al‐Hawary, I. I., Salah, A. S., Abo-Shosha, A. A., Abualreesh, M. H., & Assar, D. H. (2023) · Fish Physiology and Biochemistry · doi:10.1007/s10695-022-01165-2 · Cited by 7
Molecular and Cellular Mechanism of Muscle Regeneration
Sakuma, K., & Yamaguchi, A. (2012) · InTech eBooks · doi:10.5772/48229 · Cited by 4
Men, X., Deng, B., Tao, X., Qi, K. K., & Xu, Z. (2015) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.15.0259 · Cited by 7
Metadata
- Authors
- Musarò, A., McCullagh, K., Paul, A., Houghton, L., Dobrowolny, G., Molinaro, M., Barton, E. R., L Sweeney, H., & Rosenthal, N.
- Affiliations
- Massachusetts General Hospital (US)
- Sapienza University of Rome (IT)
- University of Pennsylvania (US)
- Corresponding author
- Rosenthal, Nadia
- ORCID
- Venue
- Nature Genetics
- Published
- 2001-02
- Volume
- 27
- Issue
- 2
- Pages
- 195-200
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W1562705858
- Cited by
- 1,137
- References
- 30
- Citations by year
- 2026: 17 · 2025: 19 · 2024: 27 · 2023: 22 · 2022: 21 · 2021: 27 · 2020: 29 · 2019: 35 · 2018: 38 · 2017: 28 · 2016: 34 · 2015: 60 · 2014: 52 · 2013: 59 · 2012: 71
- FWCI
- 17.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Genetics (clinical) › Neurogenetic and Muscular Disorders Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Keywords
- insulin-like growth factor I, skeletal muscle aging, muscle atrophy, myocyte hypertrophy, muscle regeneration, muscle fibrosis, GATA2, transgenic mouse model, muscle strength
- MeSH terms
- Animals, Cachexia, DNA-Binding Proteins, Hypertrophy, Insulin-Like Growth Factor I, Mice, Transgenic, Organ Size, Regeneration, Tissue Distribution, Transcription Factors, Cellular Senescence, Muscle, Skeletal, Neurodegenerative Diseases, Protein Isoforms, GATA2 Transcription Factor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review