Cited by 174Microtubule and mitosis dynamicsPlant Molecular Biology ResearchCancer-related Molecular Pathways

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A soybean cDNA encoding a chromatin-binding peptide inhibits mitosis of mammalian cells.

Galvez, Alfredo F., de Lumen, Benito O.·1999·Nature Biotechnology

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Abstract

A soybean cDNA encoding the small subunit peptide of a cotyledon-specific 2S albumin (Gm2S-1) is thought to play a role in arresting mitosis during the DNA endoreduplication and cell expansion phase of seed development. The peptide (termed lunasin) contains the cell adhesion motif Arg-Gly-Asp (RGD) followed by eight aspartic acid residues at its C-terminal end. A chimeric gene encoding the lunasin peptide tagged with green fluorescent protein (GFP) arrested cell division, caused abnormal spindle fiber elongation, chromosomal fragmentation, and cell lysis when transiently transfected into murine embryo fibroblast, murine hepatoma, and human breast cancer cells. Deletion of the polyaspartyl end abolished the antimitotic effect. Subcellular localization of lunasin and immunobinding assay using synthetic peptides revealed the preferential adherence of lunasin to chromatin. Immunofluorescence showed that kinetochore proteins were displaced from the centromere in lunasin-transfected cells. These observations suggest that lunasin binds to the chromatin, leading to disruption of kinetochore formation and inhibition of mitosis.

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Authors: Galvez, A. F., & de Lumen, B. O.
Affiliations: University of California, Berkeley (US)
Venue: Nature Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 1999-05
Volume: 17
Issue: 5
Pages: 495-500
ISSN: 0733-222X (ISSN-L)
1087-0156
1546-1696
DOI: 10.1038/8676
OpenAlex: W1572828491
Cited by: 174
References: 31
Citations by year: 2026: 4 · 2025: 7 · 2024: 6 · 2023: 5 · 2022: 8 · 2021: 7 · 2020: 9 · 2019: 8 · 2018: 7 · 2017: 11 · 2016: 9 · 2015: 8 · 2014: 8 · 2013: 14 · 2012: 6
FWCI: 0.82
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Biotechnology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: lunasin, 2S albumin, soybean, mitosis inhibition, antimitotic activity, centromere, chromosomal fragmentation, seed development
MeSH terms: Animals, Cell Division, Cell Line, Chromatin, Flow Cytometry, Humans, Mitosis, Peptides, Plant Proteins, Glycine max, Transfection, DNA, Complementary, Kinetochores, Fluorescent Antibody Technique, Indirect, Soybean Proteins, Mice, DNA Fragmentation

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

A soybean cDNA encoding a chromatin-binding peptide inhibits mitosis of mammalian cells.

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