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Association of Spindle Assembly Checkpoint Component XMAD2 with Unattached Kinetochores
Abstract
The spindle assembly checkpoint delays anaphase until all chromosomes are attached to a mitotic spindle. The mad (mitotic arrest-deficient) and bub (budding uninhibited by benzimidazole) mutants of budding yeast lack this checkpoint and fail to arrest the cell cycle when microtubules are depolymerized. A frog homolog of MAD2 ( XMAD2 ) was isolated and found to play an essential role in the spindle assembly checkpoint in frog egg extracts. XMAD2 protein associated with unattached kinetochores in prometaphase and in nocodazole-treated cells and disappeared from kinetochores at metaphase in untreated cells, suggesting that XMAD2 plays a role in the activation of the checkpoint by unattached kinetochores. This study furthers understanding of the mechanism of cell cycle checkpoints in metazoa and provides a marker for studying the role of the spindle assembly checkpoint in the genetic instability of tumors.
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Cited by
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Metadata
- Authors
- Chen, R.-H., Waters, J. C., Salmon, E. D., & Murray, A. W.
- Venue
- Science
- Published
- 1996-10-11
- Volume
- 274
- Issue
- 5285
- Pages
- 242-246
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2048735610
- Cited by
- 783
- References
- 0
- FWCI
- 18.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, R.-H., Waters, J. C., Salmon, E. D., & Murray, A. W. (1996). Association of Spindle Assembly Checkpoint Component XMAD2 with Unattached Kinetochores. Science. https://doi.org/10.1126/science.274.5285.242
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
