Somatic mutation hotspots correlate with DNA polymerase η error spectrum

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Items 101–200 of 300

1. Somatic hypermutation and antigen-driven selection of B cells are altered in autoimmune diseases
   Neta S. Zuckerman, Helena Hazanov, Michal Barak, Hanna Edelman, Shira Hess, Hadas Shcolnik, Deborah K. Dunn‐Walters, Ramit Mehr · 2010 · Journal of Autoimmunity
2. Mutations in human DNA polymerase η motif II alter bypass of DNA lesions
   Eitan Glick, Kellie L. Vigna, Lawrence A. Loeb · 2001 · The EMBO Journal
3. DNA Lesions and Repair in Immunoglobulin Class Switch Recombination and Somatic Hypermutation
   Zhenming Xu, Zsolt Zoltán Fülöp, YUAN ZHONG, Albert J. Evinger, Hong Zan, Paolo Casali · 2005 · Annals of the New York Academy of Sciences
4. Strand-Biased Spreading of Mutations During Somatic Hypermutation
   Shyam Unniraman, David G. Schatz · 2007 · Science
5. Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation
   Peter H.L. Krijger, Petra Langerak, Paul C.M. van den Berk, Heinz Jacobs · 2009 · The Journal of Experimental Medicine
6. Immunoglobulin heavy and light chain gene features are correlated with primary cold agglutinin disease onset and activity
   A. Ma ecka, Gunhild Trøen, Anne Maria Tierens, Ingunn Østlie, J. Ma ecki, Ulla Randen, Sigbjørn Berentsen, Geir Erland Tjønnfjord, Jan Delabie · 2016 · Haematologica
7. Genome-Wide Detection of Genes Targeted by Non-Ig Somatic Hypermutation in Lymphoma
   Yanwen Jiang, T. David Soong, Ling Wang, Ari M. Melnick, Olivier Elemento · 2012 · PLoS ONE
8. A Critical Role for REV1 in Regulating the Induction of C:G Transitions and A:T Mutations during Ig Gene Hypermutation
   Keiji Masuda, Rika Ouchida, Yingqian Li, Xiang Gao, Hiromi Mori, Jiyang O Wang · 2009 · The Journal of Immunology
9. Hypermutation in single-stranded DNA
   Natalie Saini, Dmitry A. Gordenin · 2020 · DNA repair
10. Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation
    Qiang Pan‐Hammarström, Aleksi Lähdesmäki, Yaofeng Zhao, Likun Du, Zhihui Zhao, Sicheng Wen, Víctor L. Ruiz‐Pérez, Deborah K. Dunn‐Walters, Judith A. Goodship, Lennart L G Hammarström · 2006 · The Journal of Experimental Medicine
11. Werner syndrome protein interacts functionally with translesion DNA polymerases
    Ashwini S. Kamath‐Loeb, Li Lan, Satoshi Nakajima, Akira Yasui, Lawrence A. Loeb · 2007 · Proceedings of the National Academy of Sciences
12. The Concerted Action of Msh2 and UNG Stimulates Somatic Hypermutation at A · T Base Pairs
    Darina Frieder, Mani Larijani, Cathy Collins, Marc J. Shulman, Alberto Martín · 2009 · Molecular and Cellular Biology
13. An update on the role of translesion synthesis DNA polymerases in Ig hypermutation
    Marilyn Diaz, Christopher W. Lawrence · 2005 · Trends in Immunology
14. Ectopic GC in the thymus of myasthenia gravis patients show characteristics of normal GC
    Neta S. Zuckerman, Wendy A. Howard, Jacky Bismuth, Kate L. Gibson, Hanna Edelman, Sonia Berrih‐Aknin, Deborah K. Dunn‐Walters, Ramit Mehr · 2010 · European Journal of Immunology
15. Recombinogenic Phenotype of Human Activation-Induced Cytosine Deaminase
    Vladimir P. Poltoratsky, Samuel H. Wilson, Thomas A. Kunkel, Youri I. Pavlov · 2004 · The Journal of Immunology
16. SOCS1 Mutation Subtypes Predict Divergent Outcomes in Diffuse Large B-Cell Lymphoma (DLBCL) Patients
    Birgit Schif, Jochen K. Lennerz, Christian W. Kohler, Stefan Bentink, Markus Kreuz, Ingo Melzner, Olga Ritz, Lorenz H. P. Trümper, Markus Loeffler, Rainer Spang et al. · 2012 · Oncotarget
17. Evaluation of the Antigen-Experienced B-Cell Receptor Repertoire in Healthy Children and Adults
    Hanna IJspeert, Pauline A. van Schouwenburg, David B. H. van Zessen, Ingrid Pico‐Knijnenburg, Gertjan J. A. Driessen, Andrew Stubbs, Mirjam van der Burg · 2016 · Frontiers in Immunology
18. Diverse roles of RAD18 and Y-family DNA polymerases in tumorigenesis
    Yang Yang, Yanzhe Gao, Anastasia Zlatanou, Satoshi Tateishi, Vyacheslav Yurchenko, Igor B. Rogozin, Cyrus Vaziri · 2018 · Cell Cycle
19. Mechanism of somatic hypermutation: Critical analysis of strand biased mutation signatures at A:T and G:C base pairs
    Edward J. Steele · 2008 · Molecular Immunology
20. An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody
    Jens C. Krause, Damian C. Ekiert, Terrence M. Tumpey, Patricia B. Smith, Ian A. Wilson, James E. Crowe · 2011 · mBio
21. Transcriptional pausing and stalling causes multiple clustered mutations by human activation‐induced deaminase
    Chandrika Canugovi, Mala Samaranayake, Ashok S. Bhagwat · 2008 · The FASEB Journal
22. Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses
    K. Kuwahara, Satoru Fujimura, Yoshimasa Takahashi, Naomi Nakagata, Toshitada Takemori, Shinichi Aizawa, Nobuo Sakaguchi · 2004 · Proceedings of the National Academy of Sciences
23. A unique error signature for human DNA polymerase ν
    Mercedes E. Arana, Kei‐ichi Takata, Miguel García–Díaz, Richard Dean Wood, Thomas A. Kunkel · 2006 · DNA repair
24. Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human naïve and memory B cells
    Cuixia Tian, Grace K. Luskin, Kevin M. Dischert, James N. Higginbotham, Bryan E. Shepherd, James E. Crowe · 2006 · Molecular Immunology
25. Immunoglobulin Somatic Hypermutation: Double-Strand DNA Breaks, AID and Error-Prone DNA Repair
    Xiaoping Wu, Junli Feng, Atsumasa Komori, Edmund C. Kim, Hong Zan, Paolo Casali · 2003 · Journal of Clinical Immunology
26. Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA
    Sukhdev S. Brar, Elizabeth J. Sacho, Ingrid Teßmer, Deborah L. Croteau, Dorothy A. Erie, Marilyn Diaz · 2007 · DNA repair
27. Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies
    Joyce K. Hwang, Chong Wang, Zhou Du, Robin M. Meyers, Thomas B. Kepler, Donna S Neuberg, Peter D. Kwong, John R. Mascola, Michael Gordon Joyce, Mattia Bonsignori et al. · 2017 · Proceedings of the National Academy of Sciences
28. Genome-wide mutational signatures revealed distinct developmental paths for human B cell lymphomas
    Xiaofei Ye, Weicheng Ren, Dongbing Liu, Xiaobo Li, Wei Li, Xianhuo Wang, Fei‐Long Meng, Leng-Siew Yeap, Yong Hou, Shida Zhu et al. · 2020 · The Journal of Experimental Medicine
29. Expression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genes
    Vladimir Mayorov, Igor B. Rogozin, Linda R. Adkison, Christin Frahm, Thomas A. Kunkel, Youri I. Pavlov · 2005 · BMC Immunology
30. The Mismatch Repair Protein Msh6 Influences the In Vivo AID Targeting to the Ig Locus
    Ziqiang Li, Chunfang Zhao, Maria Dolores Iglesias-Ussel, Zhanna Polonskaya, Min Zhuang, Guozhe Yang, Zhonghui Katie Luo, Winfried Edelmann, Matthew D. Scharff · 2006 · Immunity
31. Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites
    Shyam Twayana, A. Bacolla, Angelica Barreto-Galvez, R. B. De-Paula, William C. Drosopoulos, Settapong T. Kosiyatrakul, E. Bouhassira, J. Tainer, Advaitha Madireddy, C. Schildkraut · 2021 · Proceedings of the National Academy of Sciences of the United States of America
32. The Role of Polymerase η in Somatic Hypermutation Determined by Analysis of Mutations in a Patient with Xeroderma Pigmentosum Variant
    Şule Yavuz, Akif Selim Yavuz, Kenneth H. Kraemer, Peter E. Lipsky · 2002 · The Journal of Immunology
33. Beyond Hot Spots: Biases in Antibody Somatic Hypermutation and Implications for Vaccine Design
    Chaim A. Schramm, Daniel C. Douek · 2018 · Frontiers in Immunology
34. Altered Ig Hypermutation Pattern and Frequency in Complementary Mouse Models of DNA Polymerase ζ Activity
    Janssen Daly, Katarzyna Bębenek, Danielle L. Watt, Kathleen Richter, Chuancang Jiang, Ming‐Lang Zhao, Madhumita Ray, W. Glenn McGregor, Thomas A. Kunkel, Marilyn Diaz · 2012 · The Journal of Immunology
35. AID‐Initiated Purposeful Mutations in Immunoglobulin Genes
    Myron F. Goodman, Matthew D. Scharff, Floyd E. Romesberg · 2007 · Advances in immunology
36. The absence of DNA polymerase κ does not affect somatic hypermutation of the mouse immunoglobulin heavy chain gene
    Takeyuki Shimizu, Yoichi Shinkai, Tomoo Ogi, Haruo Ohmori, Takachika Azuma · 2003 · Immunology Letters
37. The evolution within us
    Cobey, Sarah, Wilson, Patrick, Matsen, Frederick A. · 2015 · Philosophical Transactions of the Royal Society B: Biological Sciences
38. Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymus
    Jeannine A. Ott, Caitlin D. Castro, Thaddeus C. Deiss, Yuko Ohta, Martin F. Flajnik, Michael F. Criscitiello · 2018 · eLife
39. Computational analyses show A-to-G mutations correlate with nascent mRNA hairpins at somatic hypermutation hotspots
    Edward J. Steele, Robyn Alice Lindley, Jiayu Wen, Georg F. Weiller · 2006 · DNA repair
40. High Mutability of the Tumor Suppressor Genes RASSF1 and RBSP3 (CTDSPL) in Cancer
    Vladimir I. Kashuba, Tatiana V. Pavlova, Григорьева Эльвира Витальевна, Alexey S. Kutsenko, Surya Pavan Yenamandra, Jingfeng Li, Fuli Wang, Alexei I. Protopopov, Veronika I. Zabarovska, Vera N. Senchenko et al. · 2009 · PLoS ONE
41. DNA polymerase <b>η</b> mutational signatures are found in a variety of different types of cancer
    Rogozin, Igor B., Goncearenco, Alexander, Lada, Artem G., De, Subhajyoti, Yurchenko, Vyacheslav, Nudelman, German, Panchenko, Anna R., Cooper, David N., Pavlov, Youri I. · 2018 · Cell Cycle
42. Genome Instability in Multiple Myeloma: Facts and Factors
    Anna Yu. Aksenova, Anna S. Zhuk, Artem G. Lada, Irina V. Zotova, Elena Igorevna Stepchenkova, Ivan Ivanovich Kostroma, Sergey V. Gritsaev, Youri I. Pavlov · 2021 · Cancers
43. Mesoscale DNA feature in antibody-coding sequence facilitates somatic hypermutation
    Yanyan Wang, Senxin Zhang, Xinrui Yang, Joyce K. Hwang, Chuanzong Zhan, Chaoyang Lian, Chong Wang, Tuantuan Gui, Binbin Wang, Xia Xie et al. · 2023 · Cell
44. MSH2/MSH6 Complex Promotes Error-Free Repair of AID-Induced dU:G Mispairs as well as Error-Prone Hypermutation of A:T Sites
    Sergio Roa, Ziqiang Li, Jonathan U. Peled, Chunfang Zhao, Winfried Edelmann, Matthew D. Scharff · 2010 · PLoS ONE
45. Overexpression of human DNA polymerase (Pol ) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate
    José F. Ruiz · 2004 · Nucleic Acids Research
46. Natural Evolution of a Human Virus-Specific Antibody Gene Repertoire by Somatic Hypermutation Requires Both Hotspot-Directed and Randomly-Directed Processes
    Jörn-Hendrik Weitkamp, Bonnie LaFleur, Harry B. Greenberg, James E. Crowe · 2005 · Human Immunology
47. A Role for the MutL Mismatch Repair Mlh3 Protein in Immunoglobulin Class Switch DNA Recombination and Somatic Hypermutation
    Xiaoping Wu, Connie Y. Tsai, Marienida B. Patam, Hong Zan, Jessica P. Chen, Steven M. Lipkin, Paolo Casali · 2006 · The Journal of Immunology
48. Regulation of the error-prone DNA polymerase Polκ by oncogenic signaling and its contribution to drug resistance
    Kelsey Temprine, Nathaniel R. Campbell, Ting Hsiang Huang, Erin M. Langdon, Theresa Simon-Vermot, Krisha Mehta, Averill Clapp, Mollie E. Chipman, Richard Mark White · 2020 · Science Signaling
49. Evaluation of Molecular Models for the Affinity Maturation of Antibodies: Roles of Cytosine Deamination by AID and DNA Repair
    Mala Samaranayake, Janusz Marek Bujnicki, Michael A. Carpenter, Ashok S. Bhagwat · 2006 · Chemical Reviews
50. Activation induced deaminase mutational signature overlaps with CpG methylation sites in follicular lymphoma and other cancers
    Rogozin, Igor B., Lada, Artem G., Goncearenco, Alexander, Green, Michael R., De, Subhajyoti, Nudelman, German, Panchenko, Anna R., Koonin, Eugene V., Pavlov, Youri I. · 2016 · Scientific Reports
51. Role of the translocation partner in protection against AID-dependent chromosomal translocations
    Mila Janković, Davide F. Robbiani, Yair Dorsett, Thomas Eisenreich, Yang Xu, Alexander Tarakhovsky, André Nussenzweig, Michel C. Nussenzweig · 2009 · Proceedings of the National Academy of Sciences
52. Lamarck and Panspermia - On the Efficient Spread of Living Systems Throughout the Cosmos.
    E. Steele, R. M. Gorczynski, R. Lindley, Yong-Sheng Liu, R. Temple, G. Tokoro, D. T. Wickramasinghe, N. Wickramasinghe · 2019 · Progress in Biophysics and Molecular Biology
53. Unravelling roles of error-prone DNA polymerases in shaping cancer genomes
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54. Activation-induced cytidine deaminase (AID) is strongly expressed in the fetal bovine ileal Peyer's patch and spleen and is associated with expansion of the primary antibody repertoire in the absence of exogenous antigens
    Jenni Liljavirta, Anna Ekman, Jacqueline S. Knight, Anton Pernthaner, Antti Iivanainen, Mikael Niku · 2013 · Mucosal Immunology
55. Hypermutation at A-T Base Pairs: The A Nucleotide Replacement Spectrum Is Affected by Adjacent Nucleotides and There Is No Reverse Complementarity of Sequences Flanking Mutated A and T Nucleotides
    Jo Spencer, Deborah K. Dunn‐Walters · 2005 · The Journal of Immunology
56. Immunoglobulin gene rearrangement, repertoire diversity, and the allergic response
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57. AID function in somatic hypermutation and class switch recombination
    Kefei Yu · 2022 · Acta Biochimica et Biophysica Sinica
58. Microsatellite Interruptions Stabilize Primate Genomes and Exist as Population-Specific Single Nucleotide Polymorphisms within Individual Human Genomes
    Guruprasad Ananda, Suzanne E. Hile, Amanda Breski, Yanli Wang, Yogeshwar Kelkar, Kateryna D. Makova, Kristin A. Eckert · 2014 · PLoS Genetics
59. DNA Polymerases η and ι
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60. Analysis of UV-induced mutation spectra in Escherichia coli by DNA polymerase η from Arabidopsis thaliana
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61. Generation and repair of AID-initiated DNA lesions in B lymphocytes
    Zhangguo Chen, Jing Hong Wang · 2014 · Frontiers of Medicine
62. ASFV DNA Polymerase X Is Extremely Error-Prone under Diverse Assay Conditions and within Multiple DNA Sequence Contexts
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63. Genesis of the strand‐biased signature in somatic hypermutation of rearranged immunoglobulin variable genes
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64. Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias
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65. Somatic hypermutations and isotype restricted exceptionally long CDR3H contribute to antibody diversification in cattle
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66. Somatic hypermutation in immunity and cancer: Critical analysis of strand-biased and codon-context mutation signatures
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67. Somatic hypermutation of TCR γ V genes in the sandbar shark
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68. Suppressor of cytokine signaling 1gene mutation status as a prognostic biomarker in classical Hodgkin lymphoma
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69. Low-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase ζ
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70. A role for Mlh3 in somatic hypermutation
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71. Biological functions of translesion synthesis proteins in vertebrates
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72. Somatic mutation load and spectra: A record of DNA damage and repair in healthy human cells
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73. Signaling Control of Antibody Isotype Switching
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74. A high-resolution landscape of mutations in the BCL6 super-enhancer in normal human B cells
    Jiang-Cheng Shen, Ashwini S. Kamath‐Loeb, Brendan F. Kohrn, Keith R. Loeb, Bradley D. Preston, Lawrence A. Loeb · 2019 · Proceedings of the National Academy of Sciences
75. Analysis of 6912 Unselected Somatic Hypermutations in Human VDJ Rearrangements Reveals Lack of Strand Specificity and Correlation between Phase II Substitution Rates and Distance to the Nearest 3′ Activation-Induced Cytidine Deaminase Target
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76. Somatic hypermutation targeting is influenced by location within the immunoglobulin V region
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77. Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells
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78. Statistical inference of sequence-dependent mutation rates
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79. Biochemical analysis of active site mutations of human polymerase η
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80. Human DNA polymerase mu (Pol micro) exhibits an unusual replication slippage ability at AAF lesion
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81. The Protein-Protein Interface Evolution Acts in a Similar Way to Antibody Affinity Maturation
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82. The role of activation-induced deaminase in antibody diversification and genomic instability
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83. Wot the ‘L—Does MutL do?
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84. Altered spectrum of somatic hypermutation in common variable immunodeficiency disease characteristic of defective repair of mutations
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85. Polymerase μ is up‐regulated during the T cell‐dependent immune response and its deficiency alters developmental dynamics of spleen centroblasts
    Daniel Lucas, Teresa Laı́n de Lera, Manuel A. González, José F. Ruiz, Orlando Domı́nguez, Jesús C. Casanova, Carlos Martínez‐A, Luis Blanco, António Bernad · 2005 · European Journal of Immunology
86. DNA polymerase η contributes to genome-wide lagging strand synthesis
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87. Sequence-specific targeting of two bases on both DNA strands by the somatic hypermutation mechanism
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88. Codon insertion and deletion functions as a somatic diversification mechanism in human antibody repertoires.
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89. Temporal Regulation of Ig Gene Diversification Revealed by Single-Cell Imaging
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90. High-risk follicular lymphomas harbour more somatic mutations including those in the AID-motif
    Taku Tsukamoto, Masakazu Nakano, Ryuichi Sato, Hiroko Adachi, Miki Kiyota, Eri Kawata, Nobuhiko Uoshima, Satoru Yasukawa, Yoshiaki Chinen, Shinsuke Mizutani et al. · 2017 · Scientific Reports
91. Ig gene hypermutation: A mechanism is due
    Jean-Claude Weil, Barbara Bertocci, Ahmad Faili, Saïd Aoufouchi, Stéphane Frey, Annie De Smet, Sébastien Storck, Auriel Dahan, Frédéric Delbos, Sandra Weller et al. · 2002 · Advances in immunology
92. Translesion DNA Synthesis and Carcinogenesis
    Evgeniy S. Shilkin, Elizaveta O. Boldinova, Anastasia D. Stolyarenko, Р. И. Гончарова, Roman N. Chuprov‐Netochin, Rafil F. Khairullin, M. P. Smal, Аlena V. Makarova · 2020 · Biochemistry (Moscow)
93. Comparative mutational analyses of influenza A viruses
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94. The VH repertoire and clonal diversification of B cells in inflammatory myopathies
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95. Computational analysis of mutation spectra
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96. A/T-targeted somatic hypermutation: critique of the mainstream model
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97. Survival analysis of DNA mutation motifs with penalized proportional hazards
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98. ADAR1 Protein Induces Adenosine-targeted DNA Mutations in Senescent Bcl6 Gene-deficient Cells
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99. Hypothesis driven single nucleotide polymorphism search (HyDn-SNP-S)
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100. Identification of somatic hypermutations in the TP53 gene in B-cell chronic lymphocytic leukemia
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