The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Autoimmune disease: why and where it occurs
Abstract
Autoimmune disease is controlled by genetic and environmental factors. Both of these affect susceptibility to autoimmunity at three levels: the overall reactivity of the immune system, the specific antigen and its presentation, and the target issue.
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In the citing paper
“Consistently, evidence has indicated that interactions between immune cells and non-immune tissues play critical roles in chronic inflammatory diseases and autoimmune diseases (3, 41, 49–51).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [50]
Citations
Cites
Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege
Griffith, T. S., Brunner, T., Fletcher, S. M., Green, D. R., & Ferguson, T. A. (1995) · Science · doi:10.1126/science.270.5239.1189 · Cited by 1,990
Epidemiology and estimated population burden of selected autoimmune diseases in the United States
Jacobson, D. L., Gange, S. J., Rose, N. R., & Graham, N. M. H. (1997) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1997.4412 · Cited by 1,667
Wucherpfennig, K. W., & Strominger, J. L. (1995) · Cell · doi:10.1016/0092-8674(95)90348-8 · Cited by 1,545
Positional cloning of the APECED gene
Nagamine, K., Peterson, P., Scott, H. S., Kudoh, J., Minoshima, S., Heino, M., Krohn, K. J. E., Lalioti, M. D., Mullis, P. E., Antonarakis, S. E., et al. (1997) · Nature Genetics · doi:10.1038/ng1297-393 · Cited by 1,439
Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
Botto, M., Dell' Agnola, C., Bygrave, A. E., Thompson, E. M., Cook, H. T., Petry, F., Loos, M., Pandolfi, P. P., & Walport, M. J. (1998) · Nature Genetics · doi:10.1038/ng0598-56 · Cited by 1,434
Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.
Kearney, E. R., Pape, K., Loh, D., & Jenkins, M. (1994) · Immunity · doi:10.1016/1074-7613(94)90084-1 · Cited by 1,126
bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
Strasser, A., Harris, A. W., & Cory, S. (1991) · Cell · doi:10.1016/0092-8674(91)90362-3 · Cited by 1,054
Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System
Steinman, L. (1996) · Cell · doi:10.1016/s0092-8674(00)81107-1 · Cited by 892
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
Vafiadis, P., Bennett, S. T., Todd, J. A., Nadeau, J., Grabs, R., Goodyer, C. G., Wickramasinghe, S., Colle, E., & Polychronakos, C. (1997) · Nature Genetics · doi:10.1038/ng0397-289 · Cited by 809
Spontaneous Autoimmune Disease in FcγRIIB-Deficient Mice Results from Strain-Specific Epistasis
Bolland, S. M., & Ravetch, J. V. (2000) · Immunity · doi:10.1016/s1074-7613(00)00027-3 · Cited by 757
Cited by
Sorted by citations
Begovich, A. B., Carlton, V. E. H., Honigberg, L. A., Schrodi, S. J., Chokkalingam, A. P., Alexander, H. C., Ardlie, K., Huang, Q., Smith, A. M., Spoerke, J. M., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/422827 · Cited by 1,501
IL-6 in inflammation, autoimmunity and cancer
Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453
“Instead, hyper-activation of the immune system to the target tissue may be a consequent event that is initiated by local initiators in non-immune target tissue in a manner dependent on genetic and/or environmental factors (1, 47, 48, 50).”
BackgroundCargill, M., Schrodi, S. J., Chang, M., Garcia, V. E., Brandon, R., Callis, K. P., Matsunami, N., Ardlie, K. G., Civello, D., Catanese, J. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/511051 · Cited by 1,086
Sakaguchi, N., Takahashi, T., Hata, H., Nomura, T., Tagami, T., Yamazaki, S., Sakihama, T., Matsutani, T., Negishi, I., Nakatsuru, S., et al. (2003) · Nature · doi:10.1038/nature02119 · Cited by 881
A Proposed Classification of the Immunological Diseases
McGonagle, D., & McDermott, M. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030297 · Cited by 841
Metadata
- Authors
- Marrack, P., Kappler, J., & Kotzin, B. L.
- Affiliations
- Howard Hughes Medical Institute (US)
- National Jewish Health (US)
- Venue
- Nature Medicine
- Published
- 2001-08
- Volume
- 7
- Issue
- 8
- Pages
- 899-905
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1522588191
- Cited by
- 609
- References
- 100
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 26 · 2023: 16 · 2022: 20 · 2021: 18 · 2020: 19 · 2019: 17 · 2018: 20 · 2017: 17 · 2016: 14 · 2015: 15 · 2014: 17 · 2013: 24 · 2012: 22
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (AI-18785, AI 17134, AI 22295, P01AI022295)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 37070, R01AR037070)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- autoimmune disease, genetic susceptibility, environmental factors, immunoreactivity, antigen presentation, autoantigens, pathogenesis
- MeSH terms
- Antigens, Autoimmune Diseases, Chromosome Mapping, Cross Reactions, Humans, Models, Biological
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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