Autoimmune disease: why and where it occurs

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

Griffith, T. S., Brunner, T., Fletcher, S. M., Green, D. R., & Ferguson, T. A. (1995) · Science · doi:10.1126/science.270.5239.1189 · Cited by 1,990

Epidemiology and estimated population burden of selected autoimmune diseases in the United States

Jacobson, D. L., Gange, S. J., Rose, N. R., & Graham, N. M. H. (1997) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1997.4412 · Cited by 1,667

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

Wucherpfennig, K. W., & Strominger, J. L. (1995) · Cell · doi:10.1016/0092-8674(95)90348-8 · Cited by 1,545

Positional cloning of the APECED gene

Nagamine, K., Peterson, P., Scott, H. S., Kudoh, J., Minoshima, S., Heino, M., Krohn, K. J. E., Lalioti, M. D., Mullis, P. E., Antonarakis, S. E., et al. (1997) · Nature Genetics · doi:10.1038/ng1297-393 · Cited by 1,439

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

Botto, M., Dell' Agnola, C., Bygrave, A. E., Thompson, E. M., Cook, H. T., Petry, F., Loos, M., Pandolfi, P. P., & Walport, M. J. (1998) · Nature Genetics · doi:10.1038/ng0598-56 · Cited by 1,434

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.

Kearney, E. R., Pape, K., Loh, D., & Jenkins, M. (1994) · Immunity · doi:10.1016/1074-7613(94)90084-1 · Cited by 1,126

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

Strasser, A., Harris, A. W., & Cory, S. (1991) · Cell · doi:10.1016/0092-8674(91)90362-3 · Cited by 1,054

Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System

Steinman, L. (1996) · Cell · doi:10.1016/s0092-8674(00)81107-1 · Cited by 892

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

Vafiadis, P., Bennett, S. T., Todd, J. A., Nadeau, J., Grabs, R., Goodyer, C. G., Wickramasinghe, S., Colle, E., & Polychronakos, C. (1997) · Nature Genetics · doi:10.1038/ng0397-289 · Cited by 809

Spontaneous Autoimmune Disease in FcγRIIB-Deficient Mice Results from Strain-Specific Epistasis

Bolland, S. M., & Ravetch, J. V. (2000) · Immunity · doi:10.1016/s1074-7613(00)00027-3 · Cited by 757

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

Bennett, S. T., Lucassen, A. M., Gough, S. C. L., Powell, E. E., Undlien, D. E., Pritchard, L. E., Merriman, M. E., Kawaguchi, Y., Dronsfield, M. J., Pociot, F., et al. (1995) · Nature Genetics · doi:10.1038/ng0395-284 · Cited by 746

Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40–CD40 ligand signaling in atherosclerosis

Mach, F., Schönbeck, U., Sukhova, G. K., Bourcier, T., Bonnefoy, J., Pober, J. S., & Libby, P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.1931 · Cited by 730

Genetic Analysis of Autoimmune Disease

Vyse, T. J., & Todd, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81110-1 · Cited by 716

A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease.

Wu, J., Edberg, J. C., Redecha, P. B., Bansal, V., Guyre, P. M., Coleman, K. D., Salmon, J. E., & Kimberly, R. P. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119616 · Cited by 711

Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases

Lucey, D. R., Clerici, M., & Shearer, G. M. (1996) · Clinical Microbiology Reviews · doi:10.1128/cmr.9.4.532 · Cited by 677

Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme.

Matsumoto, I., Staub, A., Benoist, C., & Mathis, D. (1999) · Science · doi:10.1126/science.286.5445.1732 · Cited by 667

Systemic Lupus Erythematosus

Kotzin, B. L. (1996) · Cell · doi:10.1016/s0092-8674(00)81108-3 · Cited by 665

Uncoupling of Immune Complex Formation and Kidney Damage in Autoimmune Glomerulonephritis

Clynes, R., Dumitru, C. D., & Ravetch, J. V. (1998) · Science · doi:10.1126/science.279.5353.1052 · Cited by 621

Williams Textbook of Endocrinology

Stoffer, S. S. (1992) · JAMA · doi:10.1001/jama.1992.03490110109043 · Cited by 606

Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice

Khare, S. D., Sarosi, I., Xia, X.-Z., McCabe, S., Miner, K. T., Solovyev, I., Hawkins, N., Kelley, M. J., Chang, D., Van, G. Y., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3370 · Cited by 594

Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases

Becker, K. G., Simon, R. M., Wilson, J., Freidlin, B., Biddison, W. E., McFarland, H. F., & Trent, J. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9979 · Cited by 591

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

Miller, S. D., Vanderlugt, C. L., Begolka, W. S., Pao, W., Yauch, R. L., Neville, K. L., Katz-Levy, Y., Carrizosa, A., & Kim, B. S. (1997) · Nature Medicine · doi:10.1038/nm1097-1133 · Cited by 565

Th1/Th2 Cells

Romagnani, S. (1999) · Inflammatory Bowel Diseases · doi:10.1097/00054725-199911000-00009 · Cited by 557

Identification of LFA-1 as a Candidate Autoantigen in Treatment-Resistant Lyme Arthritis

Gross, D. M., Forsthuber, T. G., Tary‐Lehmann, M., Etling, C., Ito, K., Nagy, Z. Á., Field, J. A., Steere, A. C., & Huber, B. T. (1998) · Science · doi:10.1126/science.281.5377.703 · Cited by 517

Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection.

Cornall, R., Cyster, J., Hibbs, M., Dunn, A., Otipoby, K., Clark, E., & Goodnow, C. (1998) · Immunity · doi:10.1016/s1074-7613(00)80554-3 · Cited by 472

Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.

Salmon, J. E., Millard, S. S., Schachter, L., Arnett, F. C., Ginzler, E. M., Gourley, M. F., Ramsey‐Goldman, R., Peterson, M. G., & Kimberly, R. P. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118552 · Cited by 468

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

Klein, L., Klugmann, M., Nave, K., Tuohy, V., & Kyewski, B. (2000) · Nature Medicine · doi:10.1038/71540 · Cited by 435

Chlamydia Infections and Heart Disease Linked Through Antigenic Mimicry

Bachmaier, K., Neu, N., de la Maza, L. M., Pal, S., Hessel, A., & Penninger, J. M. (1999) · Science · doi:10.1126/science.283.5406.1335 · Cited by 415

Myositis autoantibody inhibits histidyl-tRNA synthetase: a model for autoimmunity

Mathews, M. B., & Bernstein, R. M. (1983) · Nature · doi:10.1038/304177a0 · Cited by 411

Genetic and Physical Mapping of theLpsLocus: Identification of the Toll-4 Receptor as a Candidate Gene in the Critical Region

Poltorak, A. N., Smirnova, I., He, X., Liu, M.-Y., Huffel, C. V., Birdwell, D., Alejos, E., Silva, M. J., Du, X., Thompson, P., et al. (1998) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.1998.0201 · Cited by 387

Acceleration of Diabetes in Young Nod Mice with a CD4 + Islet-specific T Cell Clone

HASKINS, K. M., & MCDUFFIE, M. J. (1990) · Science · doi:10.1126/science.2205920 · Cited by 386

A Genomewide Screen in Multiplex Rheumatoid Arthritis Families Suggests Genetic Overlap with Other Autoimmune Diseases

Jawaheer, D., Seldin, M. F., Amos, C. I., Chen, W. V., Shigeta, R., Monteiro, J., Kern, M., Criswell, L. A., Albani, S., Nelson, J. L., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/319518 · Cited by 365

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

Wong, F. S., Visintin, I., Li, W., Flavell, R. A., & Janeway, C. A. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.1.67 · Cited by 349

Antigen‐induced arthritis in mice

Brackertz, D., Mitchell, G. F., & Mackay, I. R. (1977) · Arthritis & Rheumatism · doi:10.1002/art.1780200314 · Cited by 342

GENETIC SUSCEPTIBILITY TO SYSTEMIC LUPUS ERYTHEMATOSUS

Vyse, T. J., & Kotzin, B. L. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.261 · Cited by 311

PRIMARY BILIARY CIRRHOSIS: IDENTIFICATION OF TWO MAJOR M2 MITOCHONDRIAL AUTOANTIGENS

Yeaman, S. J., Danner, D. J., Mutimer, D., Fussey, S. P. M., James, O., & Bassendine, M. F. (1988) · The Lancet · doi:10.1016/s0140-6736(88)91894-6 · Cited by 292

High Frequency of Autoreactive Myelin Proteolipid Protein–Specific T Cells in the Periphery of Naive Mice

Anderson, A. C., Nicholson, L. B., Legge, K. L., Turchin, V., Zaghouani, H., & Kuchroo, V. K. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.5.761 · Cited by 269

Tumour necrosis factor-alpha is required for accumulation of dendritic cells in draining lymph nodes and for optimal contact sensitization.

Cumberbatch, M., & Kimber, I. (1995) · PubMed Central · Cited by 245

Codon 17 Polymorphism of the Cytotoxic T Lymphocyte Antigen 4 Gene in Hashimoto’s Thyroiditis and Addison’s Disease1

Donner, H., Braun, J., Seidl, C., Rau, H., Finke, R., Ventz, M., Walfish, P. G., Usadel, K. H., & Badenhoop, K. W. J. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4406 · Cited by 241

Iodine-Induced Autoimmune Thyroiditis in NOD-H-2h4Mice

Rasooly, L., Burek, C. L., & Rose, N. R. (1996) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1996.0191 · Cited by 226

Human Monocyte–Derived Dendritic Cells Induce Naive T Cell Differentiation into T Helper Cell Type 2 (Th2) or Th1/Th2 Effectors

Tanaka, H., Demeure, C. E., Rubio, M., Delespesse, G., & Sarfati, M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.405 · Cited by 226

Antiislet autoantibodies usually develop sequentially rather than simultaneously

Yu, L., Rewers, M., Gianani, R., Kawasaki, E., Zhang, Y., Verge, C. F., Chase, P., KLINGENSMITH, G. J., Erlich, H., Norris, J. M., et al. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.12.8954025 · Cited by 217

The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders

Carrasco-Marı́n, E., Shimizu, J., Kanagawa, O., & Unanue, E. R. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.2.450 · Cited by 215

Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase

Hiemstra, H. S., Schloot, N. C., van Veelen, P. A., Willemen, S. J. M., Franken, K. L. M. C., van Rood, J. J., de Vries, R. R. P., Chaudhuri, A., Behan, P. O., Drijfhout, J. W., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071050898 · Cited by 209

An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity.

Sobel, E. S., Katagiri, T., Katagiri, K., Morris, S. C., Cohen, P. L., & Eisenberg, R. A. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.6.1441 · Cited by 194

Association between dietary iodine intake and prevalence of subclinical hypothyroidism in the coastal regions of Japan

Konno, N., Makita, H., Yuri, K., Iizuka, N., & Kawasaki, K. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.2.8106628 · Cited by 183

Immunological responses of healthy elderly population.

Goodwin, J. S., Searles, R., & Tung, K. S. K. (1982) · PubMed Central · Cited by 180

Induction of autoimmunity in good and poor responder mice with mouse thyroglobulin and lipopolysaccharide.

Esquivel, P., Rose, N. R., & Kong, Y. C. (1977) · The Journal of Experimental Medicine · doi:10.1084/jem.145.5.1250 · Cited by 176

Molecular Basis for HLA-DQ Associations With IDDM

Nepom, G. T., & Kwok, W. W. (1998) · Diabetes · doi:10.2337/diab.47.8.1177 · Cited by 172

Relationship of the Structure of Bacterial Lipopolysaccharides to Its Function in Mitogenesis and Adjuvanticity

Chiller, J. M., Skidmore, B. J., Morrison, D. C., & Weigle, W. O. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.7.2129 · Cited by 170

Microbial products induce autoimmune disease by an IL-12-dependent pathway

Segal, B. M., Klinman, D. M., & Shevach, E. M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.11.5087 · Cited by 166

Immunoregulatory mechanisms of the eye

Streilein, J. W., Wilbanks, G. A., & Cousins, S. W. (1992) · Journal of Neuroimmunology · doi:10.1016/0165-5728(92)90253-h · Cited by 157

Genetic dissection of systemic lupus erythematosus

Wakeland, E. K., Wandstrat, A. E., Liu, K., & Morel, L. M. (1999) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)00039-4 · Cited by 152

CD28 engagement and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivo

Vella, A. T., Mitchell, T. C., Groth, B. F. D. S., Linsley, P. S., Green, J. M., Thompson, C. B., Kappler, J. W., & Marrack, P. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.10.4714 · Cited by 148

The genetics of human systemic lupus erythematosus

Harley, J. B., Moser, K. L., Gaffney, P. M., & Behrens, T. W. (1998) · Current Opinion in Immunology · doi:10.1016/s0952-7915(98)80090-3 · Cited by 148

Molecular mimicry: Can epitope mimicry induce autoimmune disease?

Davies, J. M. (1997) · Immunology and Cell Biology · doi:10.1038/icb.1997.16 · Cited by 145

Interleukin‐2 Deficient Mice: A New Model to Study Autoimmunity and Self‐Tolerance

Horak, I. D., Löhler, J., Ma, A. I., & Smith, K. A. (1995) · Immunological Reviews · doi:10.1111/j.1600-065x.1995.tb00092.x · Cited by 142

Molecular mimicry and myasthenia gravis. An autoantigenic site of the acetylcholine receptor alpha-subunit that has biologic activity and reacts immunochemically with herpes simplex virus.

Schwimmbeck, P. L., Dyrberg, T., Drachman, D. B., & Oldstone, M. B. A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114282 · Cited by 141

Use of soluble peptide–DR4 tetramers to detect synovial T cells specific for cartilage antigens in patients with rheumatoid arthritis

Kotzin, B. L., Falta, M. T., Crawford, F., Rosloniec, E. F., Bill, J., Marrack, P., & Kappler, J. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.291 · Cited by 133

QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2

Encinas, J. A., Wicker, L. S., Peterson, L. B., Mukasa, A., Teuscher, C., Sobel, R. A., Weiner, H. L., Seidman, C. E., Seidman, J. G., & Kuchroo, V. K. (1999) · Nature Genetics · doi:10.1038/5941 · Cited by 131

Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand black mice

Vyse, T. J., Rozzo, S. J., Drake, C. G., Izui, S., & Kotzin, B. L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.11.5566 · Cited by 130

The I-Ag7 MHC Class II Molecule Linked to Murine Diabetes Is a Promiscuous Peptide Binder

Stratmann, T., Apostolopoulos, V., Mallet-Designe, V., Corper, A. L., Scott, C. A., Wilson, I. A., Kang, A. S., & Teyton, L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3214 · Cited by 129

Adult coeliac disease: Prevalence and clinical significance

Cook, H. B., Burt, M. J., Collett, J. A., Whitehead, M. R., Frampton, C. M., & CHAPMAN, B. A. (2000) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2000.02290.x · Cited by 127

CD28/CTLA4 gene region on chromosome 2q33 confers genetic susceptibility to celiac disease. A linkage and family‐based association study

Holopainen, P., Arvas, M., Sistonen, P., Mustalahti, K., Collin, P., Mäki, M., & Partanen, J. (1999) · Tissue Antigens · doi:10.1034/j.1399-0039.1999.530503.x · Cited by 126

Mimicry peptides of human PDC-E2 163-176 peptide, the immunodominant T-cell epitope of primary biliary cirrhosis

Shimoda, S., Nakamura, M., Shigematsu, H., Tanimoto, H., Gushima, T., Gershwin, E. M., & Ishibashi, H. (2000) · Hepatology · doi:10.1053/jhep.2000.8090 · Cited by 121

Peptide recognition, T cell receptor usage and HLA restriction elements of human heat‐shock protein (hsp) 60 and mycobacterial 65‐kDa hsp‐reactive T cell clones from rheumatoid synovial fluid

Quayle, A. J., Wilson, K. B., Li, S. G., Kjeldsen‐Kragh, J., Oftung, F., Shinnick, T. M., Sioud, M., Førre, Ø. T., Capra, J. D., & Natvig, J. B. (1992) · European Journal of Immunology · doi:10.1002/eji.1830220529 · Cited by 119

Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice.

Vyse, T. J., Drake, C. G., Rozzo, S. J., Roper, E., Izui, S., & Kotzin, B. L. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118975 · Cited by 116

Evidence for Common Autoimmune Disease Genes Controlling Onset, Severity, and Chronicity Based on Experimental Models for Multiple Sclerosis and Rheumatoid Arthritis

Bergsteinsdóttir, K., Yang, H.-T., Pettersson, U., & Holmdahl, R. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.3.1564 · Cited by 112

High Incidence of Thyroiditis and Anti-Thyroid Autoantibodies in NOD Mice

Bernard, N. F., Ertug, F., & Margolese, H. C. (1992) · Diabetes · doi:10.2337/diab.41.1.40 · Cited by 107

The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule.

Albani, S., Tuckwell, J., Esparza, L., Carson, D. A., & Roudier, J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115580 · Cited by 106

Genetic Dissection of SLE Pathogenesis: Adoptive Transfer of Sle1 Mediates the Loss of Tolerance by Bone Marrow-Derived B Cells

Sobel, E. S., Mohan, C., Morel, L. M., Schiffenbauer, J., & Wakeland, E. K. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.4.2415 · Cited by 105

Major Histocompatibility Complex-Directed Susceptibility to Rheumatoid Arthritis

Nepom, G. T. (1998) · Advances in immunology · doi:10.1016/s0065-2776(08)60563-5 · Cited by 104

The use of a non‐depleting anti‐CD4 monoclonal antibody to re‐establish tolerance to β cells in NOD mice

Hutchings, P. R., Reilly, L. O., Parish, N. M., Waldmann, H., & Cooke, A. (1992) · European Journal of Immunology · doi:10.1002/eji.1830220735 · Cited by 104

Homozygous hereditary C1q deficiency and systemic lupus erythematosus: A new family and the molecular basis of C1q deficiency in three families

Slingsby, J. H., Norsworthy, P. J., Pearce, G., Vaishnaw, A. K., Issler, H., Morley, B. J., & Walport, M. J. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780390419 · Cited by 96

Molecular mimicry in type 1 diabetes mellitus revisited: T-cell clones to GAD65 peptides with sequence homology to Coxsackie or proinsulin peptides do not crossreact with homologous counterpart

Schloot, N. C., Willemen, S. J. M., Duinkerken, G., Drijfhout, J. W., de Vries, R. R. P., & Roep, B. O. (2001) · Human Immunology · doi:10.1016/s0198-8859(01)00223-3 · Cited by 87

Multiple loci for multiple sclerosis

Bell, J. I., & Lathrop, G. M. (1996) · Nature Genetics · doi:10.1038/ng0896-377 · Cited by 87

Tumour necrosis factor and other cytokines in murine lupus

Theofilopoulos, A. N., & Lawson, B. R. (1999) · Annals of the Rheumatic Diseases · doi:10.1136/ard.58.2008.i49 · Cited by 85

B- and T-lymphocytes in Ocular Disease

Jakobiec, F. A., Lefkowitch, J. H., & Knowles, D. M. (1984) · Ophthalmology · doi:10.1016/s0161-6420(84)34256-7 · Cited by 85

Mapping autoimmunity genes

Griffiths, M. M., Encinas, J. A., Remmers, E. F., Kuchroo, V. K., & Wilder, R. L. (1999) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)00038-2 · Cited by 80

In Vivo Survival of Viral Antigen–specific T Cells that Induce Experimental Autoimmune Encephalomyelitis

Ufret-Vincenty, R. L., Quigley, L., Tresser, N. J., Pak, S. H., Gado, A. M., Hausmann, S., Wucherpfennig, K. W., & Brocke, S. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.9.1725 · Cited by 71

Mapping and identification of autoimmunity genes

Encinas, J. A., & Kuchroo, V. K. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00164-3 · Cited by 69

GENETIC AND ENVIRONMENTAL FACTORS IN THE IMMUNE PATHOGENESIS OF RHEUMATOID ARTHRITIS

Albani, S., Carson, D. A., & Roudier, J. (1992) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(21)00148-4 · Cited by 64

Functionally active cardiac antibodies in chronic Chagas' disease are specifically blocked by Trypanosoma cruzi antigens

Masuda, M. O., Levin, M. J., de Oliveira, S. F., Costa, P., Lopez‐Bergami, P., Almeida, N. A. D. S., Pedrosa, R. C., Ferrari, I., Hoebeke, J., & de Carvalho, A. C. C. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.14.1551 · Cited by 59

The Genes of Systemic Autoimmunity

Theofilopoulos, A. N., & Kono, D. H. (1999) · Proceedings of the Association of American Physicians · doi:10.1046/j.1525-1381.1999.99244.x · Cited by 52

Current cases in which epitope mimicry is considered as a component cause of autoimmune disease: immune-mediated (type 1) diabetes

Kukreja, A., & Maclaren, N. K. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000715 · Cited by 48

HLA-B27 associated spondyloarthropathy, an autoimmune disease based on crossreactivity between bacteria and HLA-B27?

Ringrose, J. H. (1999) · Annals of the Rheumatic Diseases · doi:10.1136/ard.58.10.598 · Cited by 43

Autoimmune determinants of rheumatic carditis: localization of epitopes in human cardiac myosin

Dell, A., Antone, S. M., Gauntt, C. J., Crossley, C. A., Clark, W. A., & Cunningham, M. W. (1991) · European Heart Journal · doi:10.1093/eurheartj/12.suppl_d.158 · Cited by 41

Expression of Costimulatory Molecule CD40 in Murine Heart With Acute Myocarditis and Reduction of Inflammation by Treatment With Anti-CD40L/B7-1 Monoclonal Antibodies

Seko, Y., Takahashi, N., Azuma, M., Yagita∥, H., Okumura, K., & Yazaki, Y. (1998) · Circulation Research · doi:10.1161/01.res.83.4.463 · Cited by 40

Clinical features of coeliac disease today

Kennedy, N. P., & Feighery, C. (2000) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(01)80004-4 · Cited by 39

Genetic control of autoimmune myocarditis mediated by myosin-specific antibodies

Kuan, A. P., Chamberlain, W., Malkiel, S., Lieu, H. D., Factor, S. M., Diamond, B., & Kotzin, B. L. (1999) · Immunogenetics · doi:10.1007/s002510050466 · Cited by 38

Familial autoimmunity and the idiopathic inflammatory myopathies

Shamim, E. A., & Miller, F. W. (2000) · Current Rheumatology Reports · doi:10.1007/s11926-000-0080-0 · Cited by 36

Cytotoxic T-cell precursors with low-level CD8 in the diabetes-prone Biobreeding rat: implications for generation of an autoimmune T-cell repertoire.

Bellgrau, D., & Lagarde, A. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.313 · Cited by 31

CD28/CTLA4 GENE REGION ON CHROMOSOME 2q33 CONFERS GENETIC SUSCEPTIBILITY TO CELIAC DISEASE

Holopainen, P., Arvas, M., Sistonen, P., Mustalahti, K., Collin, P., Mäki, M., & Partanen, J. (1999) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/j.1536-4801.1999.tb02149.x · Cited by 28

Cytokine modulation of T-lymphocyte activation by intestinal smooth muscle cells

Hogaboam, C. M., Snider, D., & Collins, S. M. (1997) · Gastroenterology · doi:10.1053/gast.1997.v112.pm9178691 · Cited by 26

Pemphigus — Decoding the Cellular Language of Cutaneous Autoimmunity

Edelson, R. L. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007063430111 · Cited by 26

T-Lymphopenia and T-Cell Imbalance in Diabetic db/db Mice

Boillot, D., Assan, R., Dardenne, M., Debray-Sachs, M., & Bach, J. (1986) · Diabetes · doi:10.2337/diab.35.2.198 · Cited by 14

Cytokines as determinants of disease and disease interactions

Sher, A., Gazzinelli, R. T., Jankovic, D. L., Scharton‐Kersten, T., Yap, G. S., Doherty, T. M., & Wynn, T. A. (1998) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x1998000100011 · Cited by 13

Sandwich ELISA for the measurement of Apo-E4 levels in serum and the estimation of the allelic status of Apo-E4 isoforms

Uchida, Y., Ito, S., & Nukina, N. (2000) · Journal of Clinical Laboratory Analysis · doi:10.1002/1098-2825(20001212)14:6 · Cited by 12

Immune deficiency, autoimmunity and aging.

Yunis, E. J., Fernandes, G., & Greenberg, L. J. (1975) · PubMed · Cited by 9

Development of CD4+ Effector T Cells and Susceptibility to Infectious Diseases

Locksley, R. M., Fowell, D. J., Shinkai, K., Wakil, A. E., Lacy, D. A., & Bix, M. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-5355-7_6 · Cited by 7

A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis

Begovich, A. B., Carlton, V. E. H., Honigberg, L. A., Schrodi, S. J., Chokkalingam, A. P., Alexander, H. C., Ardlie, K., Huang, Q., Smith, A. M., Spoerke, J. M., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/422827 · Cited by 1,501

IL-6 in inflammation, autoimmunity and cancer

Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453

A Large-Scale Genetic Association Study Confirms IL12B and Leads to the Identification of IL23R as Psoriasis-Risk Genes

Cargill, M., Schrodi, S. J., Chang, M., Garcia, V. E., Brandon, R., Callis, K. P., Matsunami, N., Ardlie, K. G., Civello, D., Catanese, J. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/511051 · Cited by 1,086

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

Sakaguchi, N., Takahashi, T., Hata, H., Nomura, T., Tagami, T., Yamazaki, S., Sakihama, T., Matsutani, T., Negishi, I., Nakatsuru, S., et al. (2003) · Nature · doi:10.1038/nature02119 · Cited by 881

A Proposed Classification of the Immunological Diseases

McGonagle, D., & McDermott, M. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030297 · Cited by 841

Autoimmune Disease as a Multifactorial Process: The Interplay of Genetics, Environment, and Immune Regulation

Chen, C. (2026) · International Journal of Clinical and Experimental Medicine Research · doi:10.26855/ijcemr.2026.07.002

Analysis of Autoimmune Disease: Mechanism, Genetic Susceptibility and Environmental Factors

Liu, L. (2023) · Theoretical and Natural Science · doi:10.54254/2753-8818/3/20220174

AUTOIMMUNITY

Steinberg, A. D. (1980) · Elsevier eBooks · doi:10.1016/b978-0-12-637140-6.50104-2

A Survey of Auto-immunity

Mackay, I. R. (1964) · Postgraduate Medicine · doi:10.1080/00325481.1964.11694971 · Cited by 3

Autoimmune disease: genetic susceptibility, environmental triggers, and immune dysregulation. Where can we develop therapies?

Kumar, M., Yip, L., Wang, F., Marty, S., & Fathman, C. G. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1626082 · Cited by 87