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Cited by 313

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

The Natural History of Pediatric Ulcerative Colitis: A Population-Based Cohort Study

Gower-Rousseau, Corinne, Dauchet, Luc, Vernier-Massouille, Gwénola, Tilloy, Emmanuelle, Brazier, Franck, Merle, Véronique, Dupas, Jean-Louis, Savoye, Guillaume, Baldé, Mamadou, Marti, Raymond, Lerebours, Éric, Cortot, Antoine, Salomez, Jean-Louis, Turck, Dominique, Colombel, Jean-Frédéric·2009·The American Journal of Gastroenterology
DOI 10.1038/ajg.2009.177
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Abstract

OBJECTIVES: The natural history of ulcerative colitis (UC) has been poorly described in children. METHODS: In a geographically derived incidence cohort diagnosed from 1988 to 2002, we identified 113 UC patients (age 0-17 years at diagnosis) with a follow-up of at least 2 years. The cumulative risk of colectomy was estimated by the Kaplan-Meier method. Risk factors for disease extension were assessed with logistic regression models, and risk factors for colectomy with Cox hazards proportional models. RESULTS: Median follow-up time was 77 months (46-125). At diagnosis, 28% of patients had proctitis, 35% left-sided colitis, and 37% extensive colitis. Disease course was characterized by disease extension in 49% of patients. A delay in diagnosis of more than 6 months and a family history of inflammatory bowel disease were associated with an increased risk of disease extension, with odds ratios of 5.0 (1.2-21.5) and 11.8 (1.3-111.3), respectively. The cumulative rate of colectomy was 8% at 1 year, 15% at 3 years, and 20% at 5 years. The presence of extra-intestinal manifestations (EIMS) at diagnosis was associated with an increased risk of colectomy (hazard ratio (HR)=3.5 (1.2-10.5)). Among the patients with limited disease at diagnosis, the risk of colectomy was higher in those who experienced disease extension than in those who did not (HR=13.3 1.7-101.7). CONCLUSIONS: Pediatric UC was characterized by widespread localization at diagnosis and a high rate of disease extension. Twenty percent of children had their colon removed after 5 years. The colectomy rate was influenced by disease extension and was associated with the presence of EIMS at diagnosis.

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Metadata

Authors
Gower-Rousseau, C., Dauchet, L., Vernier-Massouille, G., Tilloy, E., Brazier, F., Merle, V., Dupas, J.-L., Savoye, G., Baldé, M., Marti, R., Lerebours, É., Cortot, A., Salomez, J.-L., Turck, D., & Colombel, J.-F.
Venue
The American Journal of Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2009-05-12
Volume
104
Issue
8
Pages
2080-2088
ISSN
  • 0002-9270 (ISSN-L)
  • 1572-0241
DOI
10.1038/ajg.2009.177
OpenAlex
W2062836275
Cited by
313
References
42
FWCI
8.02
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The Natural History of Pediatric Ulcerative Colitis: A Population-Based Cohort Study. https://app.cochat.ai/papers/10.1038/ajg.2009.177
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Gower-Rousseau, C., Dauchet, L., Vernier-Massouille, G., Tilloy, E., Brazier, F., Merle, V., Dupas, J.-L., Savoye, G., Baldé, M., Marti, R., Lerebours, É., Cortot, A., Salomez, J.-L., Turck, D., & Colombel, J.-F. (2009). The Natural History of Pediatric Ulcerative Colitis: A Population-Based Cohort Study. The American Journal of Gastroenterology. https://doi.org/10.1038/ajg.2009.177

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