CoChat
Sign Up
Cited by 296Pancreatitis Pathology and TreatmentGallbladder and Bile Duct DisordersSepsis Diagnosis and Treatment

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Elevated Serum Triglycerides are Independently Associated With Persistent Organ Failure in Acute Pancreatitis

Nawaz, Haq, Koutroumpakis, Efstratios, Easler, Jeffrey, Slivka, Adam, Whitcomb, David C, Singh, Vijay P, Yadav, Dhiraj, Papachristou, Georgios I·2015·American Journal of Gastroenterology
DOI 10.1038/ajg.2015.261
Open this paper in CoChat — free account

Abstract

OBJECTIVES: Hypertriglyceridemia (HTG) represents a major health problem with prevalence exceeding 30% in the U.S. The present study aims to assess the effect of elevated serum triglyceride (TG) levels on the severity of acute pancreatitis (AP). METHODS: Prospectively enrolled AP patients were categorized into normal, mild, moderate, and severe/very severe categories based on their TG levels and compared in respect to demographics, comorbidities, and clinical outcomes. Multivariate analysis determined whether elevated TG levels were independently associated with persistent organ failure. RESULTS: Two hundred and one out of 400 AP patients had serum TGs measured within 72 h of presentation, of which 115 had normal TG levels and 86 HTG (20 mild, 41 moderate, and 25 severe/very severe). Patients with HTG were of younger age (44 vs. 52 years), predominantly male (65% vs. 45%), obese (57% vs. 34%), diabetic (38% vs. 17%), and developed more frequently persistent organ failure (40% vs. 17%) compared with those with normal TGs (P<0.02). The rate of persistent organ failure increased proportionally with HTG severity grades (17% when normal TGs, 30% in mild, 39% in moderate, and 48% in severe/very severe HTG, Ptrend<0.001). On multivariate analysis controlling for age, gender, body mass index, diabetes, and alcohol etiology, moderate HTG (odds ratio (OR), 2.6; P=0.04) and severe/very severe HTG (OR, 4.9; P=0.009) were independently associated with persistent organ failure. CONCLUSIONS: Elevated serum TGs in AP patients are independently and proportionally correlated with persistent organ failure regardless of etiology. TG-mediated lipotoxicity may be an attractive target to design novel interventions for severe AP.

Overview

Integrity signals

Registry

Crossref · 10.1038/ajg.2015.261

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 41 references

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Nawaz, H., Koutroumpakis, E., Easler, J., Slivka, A., Whitcomb, D. C., Singh, V. P., Yadav, D., & Papachristou, G. I.
Affiliations
  • University of Pittsburgh Medical Center (US)
  • Mayo Clinic in Arizona (US)
  • VA Pittsburgh Healthcare System (US)
Corresponding author
Papachristou, Georgios I
ORCID
Venue
American Journal of Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-10
Volume
110
Issue
10
Pages
1497-1503
ISSN
0002-9270 (ISSN-L)
DOI
10.1038/ajg.2015.261
OpenAlex
W2165736533
Semantic Scholar
83ea41698f976f440bac3ce344db8266d6f3eabb
Cited by
296
References
41
Citations by year
2026: 30 · 2025: 47 · 2024: 24 · 2023: 37 · 2022: 29 · 2021: 25 · 2020: 27 · 2019: 30 · 2018: 20 · 2017: 17 · 2016: 10
FWCI
15.79
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (unspecified)
Locations
  • The American Journal of Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
  • Health Sciences › Medicine › Gastroenterology › Gallbladder and Bile Duct Disorders
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Keywords
acute pancreatitis, hypertriglyceridemia, serum triglycerides, persistent organ failure, disease severity, lipotoxicity, clinical outcomes
MeSH terms
Acute Disease, Adult, Age Factors, Aged, Diabetes Mellitus, Female, Humans, Male, Middle Aged, Multiple Organ Failure, Obesity, Pancreatitis, Prospective Studies, Severity of Illness Index, Sex Factors, Triglycerides, United States, Hypertriglyceridemia, Cohort Studies, Comorbidity, Body Mass Index, Multivariate Analysis, Logistic Models, Pancreatitis, Alcoholic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review