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Cited by 689

The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.

ACG and CAG Clinical Guideline: Management of Dyspepsia

Moayyedi, Paul M, Lacy, Brian E, Andrews, Christopher N, Enns, Robert A, Howden, Colin W, Vakil, Nimish·2017·American Journal of Gastroenterology

Abstract

We have updated both the American College of Gastroenterology (ACG) and the Canadian Association of Gastroenterology (CAG) guidelines on dyspepsia in a joint ACG/CAG dyspepsia guideline. We suggest that patients ≥60 years of age presenting with dyspepsia are investigated with upper gastrointestinal endoscopy to exclude organic pathology. This is a conditional recommendation and patients at higher risk of malignancy (such as spending their childhood in a high risk gastric cancer country or having a positive family history) could be offered an endoscopy at a younger age. Alarm features should not automatically precipitate endoscopy in younger patients but this should be considered on a case-by-case basis. We recommend patients <60 years of age have a non-invasive test Helicobacter pylori and treatment if positive. Those that are negative or do not respond to this approach should be given a trial of proton pump inhibitor (PPI) therapy. If these are ineffective tricyclic antidepressants (TCA) or prokinetic therapies can be tried. Patients that have an endoscopy where no pathology is found are defined as having functional dyspepsia (FD). H. pylori eradication should be offered in these patients if they are infected. We recommend PPI, TCA and prokinetic therapy (in that order) in those that fail therapy or are H. pylori negative. We do not recommend routine upper gastrointestinal (GI) motility testing but it may be useful in selected patients.

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Metadata

Authors
Moayyedi, P. M., Lacy, B. E., Andrews, C. N., Enns, R. A., Howden, C. W., & Vakil, N.
Venue
American Journal of Gastroenterology
Published
2017-07
Volume
112
Issue
7
Pages
988-1013
ISSN
0002-9270 (ISSN-L)
OpenAlex
W2694232428
Cited by
689
References
157
FWCI
50.72
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: ACG and CAG Clinical Guideline: Management of Dyspepsia. https://app.cochat.ai/papers/10.1038/ajg.2017.154
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Moayyedi, P. M., Lacy, B. E., Andrews, C. N., Enns, R. A., Howden, C. W., & Vakil, N. (2017). ACG and CAG Clinical Guideline: Management of Dyspepsia. American Journal of Gastroenterology. https://doi.org/10.1038/ajg.2017.154

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.