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Endothelial-cell proliferation in experimental tumours

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Denekamp, J, Hobson, B·1982·British Journal of Cancer

DOI 10.1038/bjc.1982.263PMC PMC2011157

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Abstract

The proliferation characteristics of vascular endothelium have been studied in 131 individual experimental tumours, representing 18 transplanted tumour lines. The labelling index (LI) is high in most tumours, with a mean value of 0.9%, regardless of the growth rate of the tumours, or whether different tumour types are considered or individual tumours from within one line are studied in detail. A similar high LI value has been found by others for a human tumour. These high LI values may even underestimate the proliferation in new capillary buds. The high proliferative index of tumour endothelium is in marked contrast with the previously reported low 3HTdR uptake into normal tissue blood vessels. It seems likely that it is the type of new vessels formed that will influence tumour growth rates more than the simple rate of endothelial-cell proliferation. The large difference between the proliferation characteristics of tumour endothelium and normal tissue endothelium, recently identified as a possible approach for tumour therapy, has now been confirmed for a range of animal tumours and a human tumour.

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Authors: Denekamp, J., & Hobson, B.
Affiliations: Mount Vernon Hospital (GB)
Venue: British Journal of Cancer
Publisher: Springer Science and Business Media LLC
Published: 1982-11
Volume: 46
Issue: 5
Pages: 711-720
ISSN: 0007-0920 (ISSN-L)
1532-1827
DOI: 10.1038/bjc.1982.263
PMC: PMC2011157
OpenAlex: W2059927830
Cited by: 237
References: 26
Citations by year: 2025: 2 · 2024: 3 · 2023: 7 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 8 · 2013: 6 · 2012: 4
FWCI: 1.87
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: British Journal of Cancer (publishedVersion)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Funders: Damon Runyon Cancer Research Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
Keywords: endothelial cell proliferation, tumor vasculature, labeling index, transplantable tumors, tumor growth rate, capillary formation, 3H-thymidine uptake, tumor angiogenesis, tumour therapy
MeSH terms: Animals, Cell Division, Cell Line, Endothelium, Humans, Mice, Inbred Strains, Neoplasms, Experimental, Rats, Inbred Strains, Thymidine, Mice, Rats

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