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Endothelial-cell proliferation in experimental tumours
Open accessAbstract
The proliferation characteristics of vascular endothelium have been studied in 131 individual experimental tumours, representing 18 transplanted tumour lines. The labelling index (LI) is high in most tumours, with a mean value of 0.9%, regardless of the growth rate of the tumours, or whether different tumour types are considered or individual tumours from within one line are studied in detail. A similar high LI value has been found by others for a human tumour. These high LI values may even underestimate the proliferation in new capillary buds. The high proliferative index of tumour endothelium is in marked contrast with the previously reported low 3HTdR uptake into normal tissue blood vessels. It seems likely that it is the type of new vessels formed that will influence tumour growth rates more than the simple rate of endothelial-cell proliferation. The large difference between the proliferation characteristics of tumour endothelium and normal tissue endothelium, recently identified as a possible approach for tumour therapy, has now been confirmed for a range of animal tumours and a human tumour.
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“One hallmark of this architecture is the development of hypoxic regions, typically located in the tumor core. These arise due to the disparity between the rapid proliferation of tumor cells and the slower proliferation and disorganized arrangement of endothelial cells responsible for vascularization [103,104].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [104]
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Metadata
- Authors
- Denekamp, J., & Hobson, B.
- Affiliations
- Mount Vernon Hospital (GB)
- Venue
- British Journal of Cancer
- Published
- 1982-11
- Volume
- 46
- Issue
- 5
- Pages
- 711-720
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC2011157
- OpenAlex
- W2059927830
- Cited by
- 237
- References
- 26
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 7 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 8 · 2013: 6 · 2012: 4
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- British Journal of Cancer (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- Damon Runyon Cancer Research Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Keywords
- endothelial cell proliferation, tumor vasculature, labeling index, transplantable tumors, tumor growth rate, capillary formation, 3H-thymidine uptake, tumor angiogenesis, tumour therapy
- MeSH terms
- Animals, Cell Division, Cell Line, Endothelium, Humans, Mice, Inbred Strains, Neoplasms, Experimental, Rats, Inbred Strains, Thymidine, Mice, Rats
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