The DOI matches its Crossref record.
A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer
Open accessAbstract
Epidemiological and experimental evidence indicates that oestrogens are involved in the carcinogenic promotion of human breast cancer. We have undertaken a pilot trial of tamoxifen, an anti-oestrogen, compared to placebo given to 200 women at a high risk of developing breast cancer. The results of this trial show that acute toxicity is low and that accrual and compliance are satisfactory. Furthermore, biochemical monitoring of lipids and clotting factors indicate that tamoxifen may reduce the risk of cardiovascular deaths. At this stage no untoward long-term risks have been identified, and it is therefore proposed that a large multicentre trial should be started.
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Citations
Cited by
Kedar, R., Bourne, T. H., Collins, W. P., Campbell, S., Powles, T. J., Ashley, S., & Cosgrove, D. O. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92466-x · Cited by 531
Self-citationJordan, V. C. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm020449y · Cited by 414
Jordan, V. C. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm020450x · Cited by 396
Smith, S. G., Sestak, I., Howell, A., Forbes, J., & Cuzick, J. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.71.7439 · Cited by 51
Metadata
- Authors
- Powles, T., Hardy, Jr., Ashley, S., Farrington, G., Cosgrove, D., Davey, J., Dowsett, M., McKinna, J., Nash, A., Sinnett, H., Tillyer, C., & Treleaven, J.
- Venue
- British Journal of Cancer
- Published
- 1989-07
- Volume
- 60
- Issue
- 1
- Pages
- 126-131
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W1993193232
- Cited by
- 246
- References
- 0
- FWCI
- 9.42
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer. https://app.cochat.ai/papers/10.1038/bjc.1989.235
- The paper
- Powles, T., Hardy, Jr., Ashley, S., Farrington, G., Cosgrove, D., Davey, J., Dowsett, M., McKinna, J., Nash, A., Sinnett, H., Tillyer, C., & Treleaven, J. (1989). A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer. British Journal of Cancer. https://doi.org/10.1038/bjc.1989.235
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
