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Cited by 572

The DOI matches its Crossref record.

Cellular accumulation of the anticancer agent cisplatin: A review

Open access
Gately, DP, Howell, SB·1993·British Journal of Cancer
DOI 10.1038/bjc.1993.221
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Abstract

Acquired resistance to cisplatin (DDP) is a major clinical problem in the treatment of ovarian, testicular, and head and neck carcinomas; decreased accumulation of DDP is the most consistently observed alteration in resistant cells. It has been postulated that DDP enters the cell by passive diffusion based on the observations that DDP accumulation is proportional to the drug concentration, accumulation is not saturable, and that structural analogs of DDP do not inhibit accumulation. However, recent studies show that DDP accumulation can be specifically stimulated or inhibited by pharmacological agents and the activation of signal transduction pathways. This paper reviews the existing data on the mechanism of DDP accumulation and develops the postulate that some component of transport occurs through a gated ion channel.

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Metadata

Authors
Gately, D., & Howell, S.
Venue
British Journal of Cancer
Publisher
Springer Science and Business Media LLC
Published
1993-06
Volume
67
Issue
6
Pages
1171-1176
ISSN
  • 0007-0920 (ISSN-L)
  • 1532-1827
DOI
10.1038/bjc.1993.221
OpenAlex
W2078144803
Cited by
572
References
0
FWCI
6.10
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Cellular accumulation of the anticancer agent cisplatin: A review. https://app.cochat.ai/papers/10.1038/bjc.1993.221
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Gately, D., & Howell, S. (1993). Cellular accumulation of the anticancer agent cisplatin: A review. British Journal of Cancer. https://doi.org/10.1038/bjc.1993.221

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.