Recent advances of cocktail chemotherapy by combination drug delivery systems
Open accessAbstract
Combination chemotherapy is widely exploited for enhanced cancer treatment in the clinic. However, the traditional cocktail administration of combination regimens often suffers from varying pharmacokinetics among different drugs. The emergence of nanotechnology offers an unparalleled opportunity for developing advanced combination drug delivery strategies with the ability to encapsulate various drugs simultaneously and unify the pharmacokinetics of each drug. This review surveys the most recent advances in combination delivery of multiple small molecule chemotherapeutics using nanocarriers. The mechanisms underlying combination chemotherapy, including the synergistic, additive and potentiation effects, are also discussed with typical examples. We further highlight the sequential and site-specific co-delivery strategies, which provide new guidelines for development of programmable combination drug delivery systems. Clinical outlook and challenges are also discussed in the end.
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Combination therapy has been largely exploited for treatment of various cancers based on related pathways of oncogenesis or using agents that affect the tumor microenvironment.
“Combination therapy has been largely exploited for the treatment of various types of cancer based on related pathways of oncogenesis or utilizing a combination of agents which affect the tumor microenvironment [257, 258].”
From Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval. (2020) · cites this paper as [258]
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“Combination therapy has been largely exploited for the treatment of various types of cancer based on related pathways of oncogenesis or utilizing a combination of agents which affect the tumor microenvironment [257,258].”
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- Authors
- Hu, Q., Sun, W., Wang, C., & Gu, Z.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Gu, Zhen
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 98
- Pages
- 19-34
- ISSN
- 0169-409X (ISSN-L)
- PMC
- PMC4998845
- OpenAlex
- W2165921162
- Cited by
- 625
- References
- 197
- Citations by year
- 2026: 31 · 2025: 43 · 2024: 54 · 2023: 59 · 2022: 63 · 2021: 74 · 2020: 95 · 2019: 75 · 2018: 57 · 2017: 48 · 2016: 25
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (1UL1TR001111)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- combination chemotherapy, nanocarriers, drug synergy, potentiation, local drug delivery, cancer nanomedicine
- MeSH terms
- Animals, Antineoplastic Combined Chemotherapy Protocols, Humans, Neoplasms, Drug Delivery Systems, Nanoparticles
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