Cited by 625Nanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryAdvanced Drug Delivery Systems

Recent advances of cocktail chemotherapy by combination drug delivery systems

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Hu, Quanyin, Sun, Wujin, Wang, Chao, Gu, Zhen·2016·Advanced Drug Delivery Reviews

Abstract

Combination chemotherapy is widely exploited for enhanced cancer treatment in the clinic. However, the traditional cocktail administration of combination regimens often suffers from varying pharmacokinetics among different drugs. The emergence of nanotechnology offers an unparalleled opportunity for developing advanced combination drug delivery strategies with the ability to encapsulate various drugs simultaneously and unify the pharmacokinetics of each drug. This review surveys the most recent advances in combination delivery of multiple small molecule chemotherapeutics using nanocarriers. The mechanisms underlying combination chemotherapy, including the synergistic, additive and potentiation effects, are also discussed with typical examples. We further highlight the sequential and site-specific co-delivery strategies, which provide new guidelines for development of programmable combination drug delivery systems. Clinical outlook and challenges are also discussed in the end.

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Crossref · 10.1016/j.addr.2015.10.022

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  • Combination therapy has been largely exploited for treatment of various cancers based on related pathways of oncogenesis or using agents that affect the tumor microenvironment.

    “Combination therapy has been largely exploited for the treatment of various types of cancer based on related pathways of oncogenesis or utilizing a combination of agents which affect the tumor microenvironment [257, 258].”

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  1. [2]Stewart BW Kleihues P I.A.f.R.o. Cancer World cancer report 2003 IARC press Lyon

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Authors
Hu, Q., Sun, W., Wang, C., & Gu, Z.
Affiliations
University of North Carolina at Chapel Hill (US)
Corresponding author
Gu, Zhen
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2016-03
Volume
98
Pages
19-34
ISSN
0169-409X (ISSN-L)
OpenAlex
W2165921162
Cited by
625
References
197
Citations by year
2026: 31 · 2025: 43 · 2024: 54 · 2023: 59 · 2022: 63 · 2021: 74 · 2020: 95 · 2019: 75 · 2018: 57 · 2017: 48 · 2016: 25
FWCI
2.62
Type
journal article
Language
en
Open access
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIH (1UL1TR001111)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
combination chemotherapy, nanocarriers, drug synergy, potentiation, local drug delivery, cancer nanomedicine
MeSH terms
Animals, Antineoplastic Combined Chemotherapy Protocols, Humans, Neoplasms, Drug Delivery Systems, Nanoparticles

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