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The interaction with tubulin of a series of stilbenes based on combretastatin A-4
Open accessAbstract
A series of stilbenes, based on combretastatin A-4, were synthesised. A structure-activity study was carried out to characterise the interaction of these agents with tubulin. The substitution of small alkyl substituents for the 4'-methoxy group of combretastatin A-4 and the loss of the 3'-hydroxyl group does not have a major effect on the interaction with tubulin. trans-Stilbenes were shown to bind tubulin, but do not inhibit microtubule assembly. This work, together with previous studies, has been used to propose an idealised structure for a tubulin-binding agent of this type.
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Cited by
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Adrian, M., Jeandet, P., Veneau, J., Weston, L. A., & Bessis, R. (1997) · Journal of Chemical Ecology · doi:10.1023/b:joec.0000006444.79951.75 · Cited by 300
Jeandet, P., Delaunois, B., Conreux, A., Donnez, D., Nuzzo, V., Cordelier, S., Clément, C., & Courot, E. (2010) · BioFactors · doi:10.1002/biof.108 · Cited by 266
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Robinson, K. S., Traynor, N. J., Moseley, H., Ferguson, J., & Woods, J. A. (2010) · Toxicology in Vitro · doi:10.1016/j.tiv.2010.03.007 · Cited by 18
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Metadata
- Authors
- Woods, J., Hadfield, J., Pettit, G., Fox, B., & McGown, A.
- Venue
- British Journal of Cancer
- Published
- 1995-04
- Volume
- 71
- Issue
- 4
- Pages
- 705-711
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2006273356
- Cited by
- 175
- References
- 0
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Woods, J., Hadfield, J., Pettit, G., Fox, B., & McGown, A. (1995). The interaction with tubulin of a series of stilbenes based on combretastatin A-4. British Journal of Cancer. https://doi.org/10.1038/bjc.1995.138
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