The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The genetics of breast and ovarian cancer
Open accessAbstract
A number of genes are known to be involved in inherited susceptibility to breast and/or ovarian cancer. In the context of high-risk families the most important genes are BRCA1 on chromosome 17q, which is associated with a high penetrance of both breast and ovarian cancer, and BRCA2 on chromosome 13q, which causes a high risk of breast cancer but a lower risk of ovarian cancer. Other high-risk cancer genes that confer increased risks of breast or ovarian cancer in addition to other cancers include the hereditary non-polyposis colorectal cancer genes and the TP53 gene, which causes breast cancer as part of the Li-Fraumeni syndrome. The predisposing mutations in these genes are relatively rare in the population. More common genes which are associated with an increased, but lower, risk of breast cancer are the ataxiatelangiectasia gene and the HRAS1 gene. This paper reviews recent progress in mapping and cloning of these susceptibility genes, and provides estimates of the cancer risks associated with each gene and the frequency of predisposing mutations.
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Cites
Risks of cancer in BRCA1-mutation carriers
FORD, D. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91578-4 · Cited by 1,850
Self-citationWooster, R., Mangion, J., Eeles, R., Smith, S., Dowsett, M., Averill, D., Barrett-Lee, P., Easton, D. F., Ponder, B. A. J., & Stratton, M. R. (1992) · Nature Genetics · doi:10.1038/ng1092-132 · Cited by 250
Androgen receptor gene mutation in male breast cancer.
Lobaccaro, J.-M., Lumbroso, S., Belon, C., Galtier-Dereure, F., Bringer, J., Lesimple, T., Namer, M., Cutull, B. F., Pujol, H., & Sultan, C. (1993) · Human Molecular Genetics · doi:10.1093/hmg/2.11.1799 · Cited by 135
Cited by
Burke, W. (1997) · JAMA · doi:10.1001/jama.277.12.997 · Cited by 955
Nelson, H. D., Huffman, L. H., Fu, R., & Harris, E. L. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-143-5-200509060-00012 · Cited by 346
Metadata
- Authors
- Ford, D., & Easton, D.
- Venue
- British Journal of Cancer
- Published
- 1995-10
- Volume
- 72
- Issue
- 4
- Pages
- 805-812
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2085390184
- Cited by
- 264
- References
- 3
- FWCI
- 10.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ford, D., & Easton, D. (1995). The genetics of breast and ovarian cancer. British Journal of Cancer. https://doi.org/10.1038/bjc.1995.417
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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