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Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)
Open accessAbstract
The effect of insulin-like growth factor II (IGF-II) on tumour development in the mouse mammary gland was studied. To promote extra IGF-II expression in the mammary gland, sheep beta-lactoglobulin regulatory elements were attached to the coding regions of the mouse Igf-2 gene and injected into the pronuclei of mouse zygotes. Mammary tumours developed in each of the four independent lines of mice which expressed transgene IGF-II in the gland. Tumours from two of the lines grew after transplantation to both male and female hosts. Primary tumours contained stromal and epithelial regions, but the tumours were dominated by mammary adenocarcinoma after transplantation. The tumours expressed high levels of Igf-2 mRNA transcribed from the integrated transgenes.
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Citations
Cited by
Calle, E. E., & Thun, M. J. (2004) · Oncogene · doi:10.1038/sj.onc.1207751 · Cited by 769
Cardiff, R. D., Anver, M. R., Gusterson, B. A., Hennighausen, L., Jensen, R. A., Merino, M. J., Rehm, S., Russo, J., Tavassoli, F. A., Wakefield, L. M., et al. (2000) · Oncogene · doi:10.1038/sj.onc.1203277 · Cited by 489
Growth hormone, the insulin-like growth factor axis, insulin and cancer risk
Clayton, P. E., Banerjee, I., Murray, P. G., & Renehan, A. G. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.171 · Cited by 364
Systemic Complications of Acromegaly and the Impact of the Current Treatment Landscape: An Update
Gadelha, M. R., Kasuki, L., Lim, D. S. T., & Fleseriu, M. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00115 · Cited by 363
Transactivation of Igf2 in a mouse model of Beckwith–Wiedemann syndrome
Sun, F.-L., Dean, W. L., Kelsey, G., Allen, N. D., & Reik, W. (1997) · Nature · doi:10.1038/39797 · Cited by 332
Metadata
- Authors
- Bates, P., Fisher, R., Ward, A., Richardson, L., Hill, D., & Graham, C.
- Venue
- British Journal of Cancer
- Published
- 1995-11
- Volume
- 72
- Issue
- 5
- Pages
- 1189-1193
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2057645543
- Cited by
- 187
- References
- 0
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II). https://app.cochat.ai/papers/10.1038/bjc.1995.484
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- Bates, P., Fisher, R., Ward, A., Richardson, L., Hill, D., & Graham, C. (1995). Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II). British Journal of Cancer. https://doi.org/10.1038/bjc.1995.484
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
