Histopathology of breast cancer in relation to age
Open accessAbstract
Histological reports of 1869 consecutive women with invasive breast cancer have been reviewed to determine whether histological features of the tumour's were related to the patients' age. The patients, treated between 1983 and 1992, were divided into four groups, based on age. There were 148 aged < or = 39 years, 355 aged 40-49 years, 984 aged 50-69 years and 382 aged 70 years or more. The most outstanding finding was the increase in incidence of grade III infiltrating ductal carcinoma in those aged < or = 39 years (P < 0.0001). Certain tumour types, in particular lobular, were reported more frequently in the oldest age group. Additionally, there was a significant reduction of axillary lymph node metastases, vascular invasion and lymphoplasmacytic stromal reaction with increasing age, all of which were independent of tumour grade. These data suggest that there may be age-related changes in the histology of breast cancer and, in some cases, less aggressive features in the elderly. However, as the life expectancy of women over the age of 70 may be many years, treatment should be based on histological prognostic features of the primary tumour rather than age alone.
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In a retrospective analysis of 1869 women with breast cancer, the incidence of invasive ductal carcinoma increased in patients <39 years of age.
“Another study retrospectively analyzed the histological report of 1869 women with breast cancer and found that the incidence of invasive ductal carcinoma increased in patients < 39 years of age [76].”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [76]
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Immunosenescence: a key player in cancer development
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- Authors
- Fisher, C., Egan, M., Smith, P., Wicks, K., Millis, R., & Fentiman, I.
- Affiliations
- Guy's Hospital (GB)
- Corresponding author
- Fentiman, IS
- Venue
- British Journal of Cancer
- Published
- 1997-02
- Volume
- 75
- Issue
- 4
- Pages
- 593-596
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC2063298
- OpenAlex
- W2055129560
- Cited by
- 164
- References
- 19
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 7 · 2014: 5 · 2013: 9 · 2012: 3
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- British Journal of Cancer (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- breast cancer, age, histopathology, invasive ductal carcinoma, lobular carcinoma, tumor grade, axillary lymph node metastasis, vascular invasion, older women, prognostic factors
- MeSH terms
- Adult, Age Factors, Aged, Breast Neoplasms, Adenocarcinoma, Mucinous, Female, Humans, Lymphatic Metastasis, Middle Aged, Age Distribution, Carcinoma, Ductal, Breast, Carcinoma, Lobular, Carcinoma, Medullary
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