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Influence of glioma tumour microenvironment on the transport of ANG1005 via low-density lipoprotein receptor-related protein 1
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LRP-1 is highly expressed in most gliomas, and its silencing significantly decreases An2 uptake in vitro in a U87 glioma cell model.
“LRP-1 has been reported to be highly expressed in most gliomas, and its silencing found to significantly decrease An2 uptake in vitro in a U87 glioma cell model [21].”
From MT1-MMP Expression Levels and Catalytic Functions Dictate LDL Receptor-Related Protein-1 Ligand Internalization Capacity in U87 Glioblastoma Cells (2022) · cites this paper as [21]
Conjugation of An2 to small therapeutic molecules significantly increased their internalization across the BBTB upon systemic administration.
“Conjugation of this peptide to small therapeutic molecules such as paclitaxel, doxorubicin or etoposide significantly increased their internalization across the BBTB upon systemic administration [20,21].”
From MT1-MMP Expression Levels and Catalytic Functions Dictate LDL Receptor-Related Protein-1 Ligand Internalization Capacity in U87 Glioblastoma Cells (2022) · cites this paper as [21]
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Vieira, D., & Gamarra, L. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s117210 · Cited by 427
Muolokwu, C. E., Chaulagain, B., Gothwal, A., Mahanta, A. K., Tagoe, B., Lamsal, B., & Singh, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1405423 · Cited by 42
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Metadata
- Authors
- Bertrand, Y., Currie, J.-C., Poirier, J., Demeule, M., Abulrob, A., Fatehi, D., Stanimirovic, D., Sartelet, H., Castaigne, J.-P., & Béliveau, R.
- Venue
- British Journal of Cancer
- Published
- 2011-10-25
- Volume
- 105
- Issue
- 11
- Pages
- 1697-1707
- ISSN
- 0007-0920
- 1532-1827
- PMC
- PMC3242593
- Cited by
- 94
- References
- 3
- Language
- en
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