CoChat
Sign Up
Cited by 908

The DOI matches its Crossref record.

LRP: a multifunctional scavenger and signaling receptor

Herz, Joachim, Strickland, Dudley K.·2001·Journal of Clinical Investigation
DOI 10.1172/jci200113992
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1172/jci200113992

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Multiple intracellular adaptor and scaffolding proteins bind the LRP 100 amino acid cytoplasmic tail.

    “Multiple intracellular adaptor and scaffolding proteins bind the LRP 100 amino acid cytoplasmic tail (16,17);”

    From The Low Density Lipoprotein Receptor-related Protein (LRP) Is a Novel β-Secretase (BACE1) Substrate (2005) · cites this paper as [16]

    The sections “Interactions with intracellular adapter and scaffold proteins” and “Structural organization of LRP” state that multiple cytoplasmic adaptor and scaffold proteins interact with the LRP tail. Our copy does not specify that the tail is 100 amino acids long, so that numerical detail is unsupported. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • LRP1 belongs to the same family as LRP5 and is known to regulate crucial processes that help maintain synaptic integrity and cholesterol homeostasis in the brain.

    “LRP1 belongs to the same family as LRP5 and is known to regulate crucial processes that help maintain synaptic integrity and cholesterol homeostasis in the brain.[44][45][46]”

    From Canonical Wnt pathway and the LDL receptor superfamily in neuronal cholesterol homeostasis and function (2024) · cites this paper as [45]

    The Introduction places LRP in the LDL receptor gene family, and “Emerging functions in neurotransmission” describes its possible role in synaptic plasticity. But the paper does not identify LRP5 as a family member, and “Lipoprotein metabolism” presents LRP-mediated uptake of cholesterol in the brain as a possibility, not an established role in cholesterol homeostasis. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • LRP's four extracellular binding domains mediate endocytosis of a wide array of ligands, including APP, apolipoprotein E and α2-macroglobulin.

    “its four extracellular binding domains mediate endocytosis of a wide array of ligands, including several of potential importance for Alzheimer disease pathophysiology: APP, apolipoprotein E and ␣ 2 -macroglobulin (16 -18).”

    From The Low Density Lipoprotein Receptor-related Protein (LRP) Is a Novel β-Secretase (BACE1) Substrate (2005) · cites this paper as [16]

  • LRP functions in the catabolism of Aβ peptides.

    “LRP also functions in the catabolism of Aβ peptides”

    From Receptor-Associated Protein (RAP) Plays a Central Role in Modulating Aβ Deposition in APP/PS1 Transgenic Mice (2008) · cites this paper as [38]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 47

  1. 10.1038/14109 · DOI · Paper page
  2. 10.1038/35036221 · DOI
  3. 10.1074/jbc.274.44.31305 · DOI · Paper page
  4. 10.1006/jmbi.1998.2115 · DOI
  5. 10.1074/jbc.273.50.33556 · DOI · Paper page
  6. 10.1074/jbc.274.20.14130 · DOI
  7. Willnow, 1994, J Biol Chem, 269, 15827, 10.1016/S0021-9258(17)40755-1 · DOI
  8. Chen, 1990, J Biol Chem, 265, 3116, 10.1016/S0021-9258(19)39742-X · DOI · Paper page
  9. 10.1016/S0092-8674(00)80782-5 · DOI · Paper page
  10. 10.1093/hmg/5.10.1589 · DOI
  11. 10.1074/jbc.272.10.6399 · DOI
  12. 10.1074/jbc.272.52.32869 · DOI
  13. 10.1073/pnas.93.20.10832 · DOI
  14. Duilio, 1998, Biochem J, 330, 513, 10.1042/bj3300513 · DOI
  15. 10.1074/jbc.M000955200 · DOI · Paper page
  16. 10.1074/jbc.M004119200 · DOI · Paper page
  17. Barnes, 2001, J Biol Chem, 276, 19119, 10.1074/jbc.M101216200 · DOI
  18. 10.1073/pnas.200238297 · DOI · Paper page
  19. 10.1016/0092-8674(92)90511-A · DOI · Paper page
  20. 10.1073/pnas.88.19.8342 · DOI · Paper page
  21. 10.1126/science.7515194 · DOI
  22. 10.1073/pnas.92.10.4537 · DOI · Paper page
  23. 10.1172/JCI1240 · DOI · Paper page
  24. 10.1073/pnas.95.11.6460 · DOI
  25. 10.1016/S0955-0674(98)80044-6 · DOI
  26. Nykjaer, 1992, J Biol Chem, 267, 14543, 10.1016/S0021-9258(18)42072-8 · DOI
  27. 10.1074/jbc.273.48.32273 · DOI
  28. 10.1038/383441a0 · DOI
  29. Sitrin, 1999, J Immunol, 163, 6193, 10.4049/jimmunol.163.11.6193 · DOI
  30. 10.1074/jbc.M909575199 · DOI
  31. 10.1074/jbc.274.42.30087 · DOI
  32. Yang, 2000, J Biol Chem, 106, 12
  33. 10.1002/ijc.2910600525 · DOI
  34. Kancha, 1994, Oncol Res, 6, 365
  35. 10.1111/j.1749-6632.1998.tb09667.x · DOI
  36. 10.1093/emboj/17.16.4617 · DOI
  37. 10.1073/pnas.91.5.1839 · DOI
  38. Kounnas, 1992, J Biol Chem, 267, 12420, 10.1016/S0021-9258(18)42291-0 · DOI
  39. 10.1038/82199 · DOI
  40. 10.1073/pnas.93.16.8699 · DOI
  41. Zhuo, 2000, J Neurosci, 20, 542, 10.1523/JNEUROSCI.20-02-00542.2000 · DOI · Paper page
  42. 10.1038/83358 · DOI
  43. 10.1172/JCI11013 · DOI · Paper page
  44. 10.1016/0092-8674(95)90320-8 · DOI · Paper page
  45. 10.1074/jbc.275.10.7410 · DOI · Paper page
  46. 10.1172/JCI10498 · DOI · Paper page
  47. 10.1159/000053076 · DOI

Cited by

Sorted by citations

Metadata

Authors
Herz, J., & Strickland, D. K.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2001-09-15
Volume
108
Issue
6
Pages
779-784
ISSN
0021-9738
DOI
10.1172/jci200113992
Cited by
908
References
0
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review