The DOI matches its Crossref record; 18 of the 19 references it cites were found in a registry or an index.
The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers
Open accessAbstract
BACKGROUND: Germline mutations in BRCA1 and BRCA2 predispose to pancreatic cancer. We estimated the incidence of pancreatic cancer in a cohort of female carriers of BRCA1 and BRCA2 mutation. We also estimated survival rates in pancreatic cancer cases from families with a BRCA mutation. METHODS: We followed 5149 women with a mutation for new cases of pancreatic cancer. The standardised incidence ratios (SIR) for pancreatic cancer were calculated based on age group and country of residence. We also reviewed the pedigrees of 8140 pedigrees with a BRCA1 or a BRCA2 mutation for those with a case of pancreatic cancer. We recorded the year of diagnosis and the year of death for 351 identified cases. RESULTS: Eight incident pancreatic cancer cases were identified among all mutation carriers. The SIR for BRCA1 carriers was 2.55 (95% CI=1.03-5.31, P=0.04) and for BRCA2 carriers was 2.13 (95% CI=0.36-7.03, P=0.3). The 5-year survival rate was 5% for cases from a BRCA1 family and 4% for cases from a BRCA2 family. CONCLUSION: The risk of pancreatic cancer is approximately doubled in female BRCA carriers. The poor survival in familial pancreatic cancer underscores the need for novel anti-tumoural strategies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Some families affected by BRCA2 mutations have an increased incidence of pancreatic ductal adenocarcinoma and breast or ovarian cancer. These families are classified as having both HBOC and hereditary pancreatic cancer.33”
From Early detection of pancreatic cancer (2020) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
Hahn, S. A., Schutte, M., Shamsul Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., et al. (1996) · Science · doi:10.1126/science.271.5247.350 · Cited by 2,337
Cancer risks in BRCA2 mutation carriers.
Olsson, H. (1999) · Journal of the National Cancer Institute · doi:10.1093/jnci/91.15.1310 · Cited by 1,404
Cancer Incidence in BRCA1 mutation carriers.
Thompson, D., & Easton, D. (2002) · Journal of the National Cancer Institute · doi:10.1093/jnci/94.18.1358 · Cited by 1,231
Caldas, C., Hahn, S. A., da Costa, L. T., Redston, M. S., Schutte, M. E. M., Seymour, A. B., Weinstein, C. L., Hruban, R. H., Yeo, C. J., & Kern, S. E. (1994) · Nature Genetics · doi:10.1038/ng0994-27 · Cited by 1,132
Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene
Jones, S., Hruban, R. H., Kamiyama, M., Borges, M., Zhang, X., Parsons, D. W., Lin, J. C.-H., Palmisano, E., Brune, K., Jaffee, E. M., et al. (2009) · Science · doi:10.1126/science.1171202 · Cited by 826 · cited 2×
“These include BRCA1 and BRCA2 (Lal et al, 2000), TP53 (Caldas et al, 1994), PALB2 (Jones et al, 2009), p16/CDKN2A (Redston et al, 1994; Ghiorzo et al, 2012), SMAD4 (Hahn et al, 1996), STK 11 (Sato et al, 2001), ataxia-telangiectasia-mutated (ATM) gene (Roberts et al, 2011) and the mismatch repair genes (MMR) (Win et a…”
Risch, H. A., McLaughlin, J. R., Cole, D. E. C., Rosen, B. P., Bradley, L., Fan, I., Tang, J., Li, S., Zhang, S., Shaw, P. A., et al. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj465 · Cited by 678
Self-citationATM Mutations in Patients with Hereditary Pancreatic Cancer
Roberts, N. J., Jiao, Y., Yu, J., Kopelovich, L., Petersen, G. M., Bondy, M. L., Gallinger, S., Schwartz, A. G., Syngal, S., Cote, M. L., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0194 · Cited by 491 · cited 1×
“…(Lal et al, 2000), TP53 (Caldas et al, 1994), PALB2 (Jones et al, 2009), p16/CDKN2A (Redston et al, 1994; Ghiorzo et al, 2012), SMAD4 (Hahn et al, 1996), STK 11 (Sato et al, 2001), ataxia-telangiectasia-mutated (ATM) gene (Roberts et al, 2011) and the mismatch repair genes (MMR) (Win et al, 2012).”
Redston, M. S., Caldas, C., Seymour, A. B., Hruban, R. H., da Costa, L., Yeo, C. J., & Kern, S. E. (1994) · PubMed · Cited by 451
Win, A. K., Young, J., Lindor, N., Tucker, K., Ahnen, D., Young, G., Buchanan, D., Clendenning, M., Giles, G., Winship, I., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.39.5590 · Cited by 324
Sato, N., Rosty, C., Jansen, M., Fukushima, N., Ueki, T., Yeo, C. J., Cameron, J. L., Iacobuzio–Donahue, C. A., Hruban, R. H., & Goggins, M. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63053-2 · Cited by 268
Flagged first, then by citations
1 of the 19 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 201–252 of 252
Heydari, K., Rismantab, S., Alizadeh‐Navaei, R., Shamshirian, A., Shadmehri, N., Lotfi, P., Kiasari, A. Z., & Shamshirian, D. (2020) · medRxiv · doi:10.1101/2020.04.07.20057190 · Cited by 2
Michaelson‐Cohen, R., Beeri, R., Golomb, E., & Levy‐Lahad, E. (2016) · Springer eBooks · doi:10.1007/978-3-319-19674-9_22 · Cited by 1
Crapé, L., Geboes, K., Kortbeek, K., Naert, E., Hoorens, A., Berrevoet, F. C., Heddeghem, N. V., & Ribeiro, S. (2024) · Acta gastro-enterologica belgica · doi:10.51821/87.4.11787 · Cited by 1
Stuursma, A., van der Vegt, B., Berger, L. P. V., ten Hoor, M. B. C., Oosterwijk, J. C., Mourits, M. J. E., & de Bock, G. H. (2025) · Cancers · doi:10.3390/cancers17101687 · Cited by 1
Genetic Aspects of Celiac Disease in Association with Pancreatic Tumors
Procházka, P. (2016) · International Journal of Celiac Disease · doi:10.12691/ijcd-2-3-6 · Cited by 1
Clinical Genetic Testing in Gastroenterology
Goodman, R. P., & Chung, D. C. (2016) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.23 · Cited by 1
A current picture of genetic counseling for familial pancreatic cancer
Sampson, J. E., & Hamman, K. J. (2016) · Expert Review of Quality of Life in Cancer Care · doi:10.1080/23809000.2016.1255552 · Cited by 1
Cell Cycle Machinery and Its Alterations in Pancreatic Cancer
Kojima, Y., Maskey, R. S., & Machida, Y. (2018) · Springer eBooks · doi:10.1007/978-1-4939-7193-0_74 · Cited by 1
Pancreatic Cancer Epidemiology and Environmental Risk Factors
Yellu, M., Kamireddy, C., & Olowokure, O. O. (2017) · Springer eBooks · doi:10.1007/978-3-319-58256-6_1 · Cited by 1
Clinical practice guidelines for interventional treatment of pancreatic cancer
Pourali, G., Donyadideh, G., Mehrabadi, S., Fiuji, H., Hassanian, S. M., Ferns, G. A., Khazaei, M., & Avan, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-19142-8.00008-5 · Cited by 1
Ishida, J., Nanno, Y., Toyama, H., Mizumoto, T., Lee, D., Urade, T., Fukushima, K., Komatsu, S., Asari, S., Yanagimoto, H., et al. (2025) · Annals of Surgical Oncology · doi:10.1245/s10434-025-18491-3 · Cited by 1
Genetic Risk Prediction in Breast Cancer
Nguyen, A., Plichta, J. K., Cintolo-Gonzalez, J., Kartal, K., Griffin, M., & Hughes, K. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-60336-0_15 · Cited by 1
Neuzillet, C. (2018) · theses.fr (ABES) · doi:10.70675/71b3d021zb0eaz45a4z95a5zdb254dc5bde0 · Cited by 1
Vyas, O. H., & Saif, M. W. (2014) · Università degli Studi di Napoli Federico II · doi:10.6092/1590-8577/2509
Neuroplastic changes in a mouse model of pancreatic ductal adenocarcinoma
Stopczynski, R. E. (2013) · D-Scholarship@Pitt (University of Pittsburgh)
Hereditary breast and ovarian cancer syndrome: Considering the complexities
Senter, L. A. (2014) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2014.10.003
Self-citationBRCA1 and BRCA2 Cancer Syndromes and Clinical Significance
Gao, F. F., & Dabbs, D. J. (2014) · Pathology Case Reviews · doi:10.1097/pcr.0000000000000021
Obermair, F., Popper, U., Romeder, F., & Rumpold, H. F. (2016) · Wiener klinisches Magazin · doi:10.1007/s00740-016-0107-4 · Cited by 1
How to Manage Cystic Tumors of the Pancreas in High-Risk Individuals
Konings, I. C. A. W., Cahen, D. L., & Bruno, M. J. (2016) · Springer eBooks · doi:10.1007/978-3-319-31882-0_14
Vyas, O. H., & Saif, M. W. (2014) · JOP, journal of the pancreas
Kaneko, T., Sato, T., Kurita, Y., Iwasaki, A., Kato, S., Kagawa, K., Hosono, K., Umeda, S., Endo, I., Nakajima, A., et al. (2017) · Suizo · doi:10.2958/suizo.32.168
Neoplasia of the Gastrointestinal Tract
Margalit, O., & DuBois, R. N. (2015) · Wiley eBooks · doi:10.1002/9781118512074.ch31
Gallbladder Adenocarcinoma as the First Manifestation of Germline BRCA1 Mutation
Al-Taee, A., Gill, A., Mahon, S. M., Lai, J., & Jallad, B. (2017) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-017-9995-9
Synthetic Lethality: Achilles Heel in Select Patient Subpopulations
Teo, M. Y., & O'Reilly, E. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-58256-6_14
Kopantsev, E. P., Гранкина, Е. В., Kopantseva, M. R., & Sverdlov, E. D. (2017) · Molecular Genetics Microbiology and Virology (Russian) · doi:10.18821/0208-0613-2017-35-3-83-88
Breast Cancer Risk Assessment and Genetic Testing
Arora, N., & Mehta, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-3438-2_29
Treatment of Advanced Pancreatic Carcinoma
Tesfaye, A. A., & Philip, P. A. (2019) · Springer eBooks · doi:10.1007/978-3-030-18890-0_15
Hereditary Breast/Ovarian Cancer Syndrome: *BRCA2*
Hicks, D. G., & Lester, S. C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-37712-6.50107-1
Vaněk, P., Freeman, M. L., & Trikudanathan, G. (2020) · Endoscopy · doi:10.1055/a-1252-2561
Cell Cycle Machinery and Its Alterations in Pancreatic Cancer
Kojima, Y., Maskey, R. S., & Machida, Y. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6631-8_74-1
Jinekolojik Onkoloji Pratiğimizde Risk Azaltıcı Cerrahi Yönetimi Gerektiren Genetik Değişiklikler
Kazancı, F., & Şahin, F. İ. (2022) · Arşiv Kaynak Tarama Dergisi · doi:10.17827/aktd.1059207
Cazacu, I. M., Singh, B. S., McAllister, F. M., Săftoiu, A., & Bhutani, M. S. (2022) · Springer eBooks · doi:10.1007/978-3-031-05724-3_4
Risk Factors and Genetic Predisposition
Li, D. (2022) · Springer eBooks · doi:10.1007/978-3-031-05724-3_2
Ductal Adenocarcinoma and Pancreatic Intraepithelial Neoplasia
(2023) · American Registry of PathologyArlington, Virginia eBooks · doi:10.55418/9781933477275-07
Other Syndromes and Genes Associated with Gastric Cancer Predisposition
Tedaldi, G., José, C. S., & Oliveíra, C. (2023) · Springer eBooks · doi:10.1007/978-3-031-21317-5_7
Katona, B. W., Long, J. M., Ahmad, N. A., Attalla, S., Bradbury, A. R., Carpenter, E. L., Clark, D. F., Constantino, G., Das, K. K., Domchek, S. M., et al. (2023) · doi:10.1158/1940-6207.c.6547030
Establishment of a Medical System with HBOC in Mind
NARUI, R., Taruno, K., & Nakamura, S. (2023) · Springer eBooks · doi:10.1007/978-981-99-5231-1_1
Pancreatic Cancer in Saudi Arabia (2005-2020): Increasing TrendPreprint
Elwali, N. E., AlShareef, S. M., & Elhassan, M. M. A. (2024) · Research Square · doi:10.21203/rs.3.rs-3958132/v1
Combined treatment for locally advanced BRCA1-associated pancreatic cancer: a case report
Kashcheeva, A. Y., Polyakov, A. N., Makiev, G. G., Магомедовна, К. Д., Chikhareva, Y., & Bazin, I. S. (2025) · Medical alphabet · doi:10.33667/2078-5631-2025-14-26-30
Wagner, J. K., Speiser, D., Zilski, N., Roehle, R., Stegen, S., & Blohmer, J. (2025) · Geburtshilfe und Frauenheilkunde · doi:10.1055/a-2737-2046
O’Shaughnessy, J., Brezden‐Masley, C., Cazzaniga, M., Dalvi, T. B., Walker, G., Bennett, J., & Ohsumi, S. (2020) · Figshare · doi:10.6084/m9.figshare.13152393
O’Shaughnessy, J., Brezden‐Masley, C., Cazzaniga, M., Dalvi, T. B., Walker, G., Bennett, J., & Ohsumi, S. (2020) · Figshare · doi:10.6084/m9.figshare.13152396
APOE and Proteomics in Chronic Inflammation
Shvetcov, A., & Finney, C. A. (2026) · Springer eBooks · doi:10.1007/978-3-031-52641-1_82-1
Ayme, A. (2013) · theses.fr (ABES) · doi:10.70675/9e63b493z9591z4b85zb3d5zb41ad5fbfe7a
APOE and Proteomics in Chronic Inflammation
Shvetcov, A., & Finney, C. A. (2026) · Springer eBooks · doi:10.1007/978-3-031-96089-5_82
Sherigar, P., Herga, S. K., Pai, A. G., Mailankody, S., & Udupa, K. (2026) · Cancer Medicine · doi:10.1002/cam4.71497 · Cited by 1
Akahori, T., Yokotani, T., Yoshizawa, A., Uchiyama, T., Yamaguchi, R., & Sho, M. (2026) · Surgical Case Reports · doi:10.70352/scrj.cr.26-0257
Synthetic lethality in cancer: mechanisms, therapeutic exploitation and clinical translation
Camps-Fajol, C., Minguillón, J., & Surrallés, J. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02954-4 · Cited by 1
Breast Cancer Genetics and Risk Assessment
Shannon, K. M., & Chittenden, A. B. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1267-4_1 · Cited by 1
Metadata
- Authors
- T. H. B. C. S. G., Iqbal, J., Ragone, A., Lubinski, J., Lynch, H. T., Moller, P., Ghadirian, P., Foulkes, W. D., Armel, S., Eisen, A., Neuhausen, S. L., Senter, L., Singer, C. F., Ainsworth, P., Kim-Sing, C., Tung, N., Friedman, E., Llacuachaqui, M., Ping, S., & Narod, S. A.
- Affiliations
- Women’s College Hospital Research and Innovation Institute (CA)
- International Hereditary Cancer Center (PL)
- Creighton University (US)
- McGill University (CA)
- University of Toronto (CA)
- Sunnybrook Health Science Centre (CA)
- City Of Hope National Medical Center (US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Comprehensive Cancer Center Vienna (AT)
- BC Cancer Agency (CA)
- Beth Israel Deaconess Medical Center (US)
- Tel Aviv University (IL)
- Corresponding author
- Narod, S A
- ORCID
- Venue
- British Journal of Cancer
- Published
- 2012-10-25
- Volume
- 107
- Issue
- 12
- Pages
- 2005-2009
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC3516682
- OpenAlex
- W2035801850
- Cited by
- 252
- References
- 19
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 6 · 2023: 17 · 2022: 23 · 2021: 20 · 2020: 26 · 2019: 18 · 2018: 19 · 2017: 28 · 2016: 24 · 2015: 20 · 2014: 22 · 2013: 9
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- www.springer.com/tdm (unspecified)
- Locations
- British Journal of Cancer (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Canadian Cancer Society Research Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- pancreatic cancer, BRCA1 mutation carriers, BRCA2 mutation carriers, hereditary cancer predisposition, cancer incidence, standardized incidence ratio, survival rate, familial pancreatic cancer
- MeSH terms
- Adult, Aged, Female, Heterozygote, Humans, Middle Aged, Pancreatic Neoplasms, Cohort Studies, Incidence, Germ-Line Mutation, BRCA1 Protein, Genes, BRCA1, Genes, BRCA2, BRCA2 Protein, Kaplan-Meier Estimate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
