Cited by 2,337Pancreatic and Hepatic Oncology ResearchGenetic factors in colorectal cancerCancer-related Molecular Pathways

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

Hahn, Stephan A., Schutte, Mieke, Shamsul Hoque, A. T. M., Moskaluk, Christopher A., da Costa, Luis T., Rozenblum, Ester, Weinstein, Craig L., Fischer, Aryeh +3 more·1996·Science

Abstract

About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To identify candidate tumor suppressor genes on 18q, a panel of pancreatic carcinomas were analyzed for convergent sites of homozygous deletion. Twenty-five of 84 tumors had homozygous deletions at 18q21.1, a site that excludes DCC (a candidate suppressor gene for colorectal cancer) and includes DPC4 , a gene similar in sequence to a Drosophila melanogaster gene ( Mad ) implicated in a transforming growth factor-β (TGF-β)-like signaling pathway. Potentially inactivating mutations in DPC4 were identified in six of 27 pancreatic carcinomas that did not have homozygous deletions at 18q21.1. These results identify DPC4 as a candidate tumor suppressor gene whose inactivation may play a role in pancreatic and possibly other human cancers.

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Crossref · 10.1126/science.271.5247.350

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Authors
Hahn, S. A., Schutte, M., Shamsul Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., & Kern, S. E.
Affiliations
  • Johns Hopkins University (US)
  • S. A. Hahn, M. Schutte, A. T. M. S. Hoque, C. A. Moskaluk, E. Rozenblum, C. L. Weinstein, A. Fischer, R. H. Hruban, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • L. T. da Costa, Graduate Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Corresponding author
Kern, Scott E.
Venue
Science
Published
1996-01-19
Volume
271
Issue
5247
Pages
350-353
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2100522747
Cited by
2,337
References
25
Citations by year
2026: 20 · 2025: 21 · 2024: 29 · 2023: 26 · 2022: 31 · 2021: 41 · 2020: 33 · 2019: 44 · 2018: 41 · 2017: 46 · 2016: 55 · 2015: 59 · 2014: 71 · 2013: 64 · 2012: 67
FWCI
70.80
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (P50CA062924, CA 62924)
Topics
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords
SMAD4, tumor suppressor, pancreatic cancer, homozygous deletion, loss of heterozygosity, TGF-beta signaling, loss-of-function mutations, candidate gene identification
MeSH terms
Alleles, Amino Acid Sequence, Animals, Base Sequence, Cell Division, Chromosome Mapping, Chromosomes, Human, Pair 18, DNA-Binding Proteins, Genetic Markers, Humans, Molecular Sequence Data, Mutation, Neoplasm Transplantation, Pancreatic Neoplasms, Proteins, Transplantation, Heterologous, Tumor Cells, Cultured, Signal Transduction, Trans-Activators, Gene Expression, Genes, Tumor Suppressor, Transforming Growth Factor beta, Gene Deletion, Mice, Smad4 Protein

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