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EMT Factors and Metabolic Pathways in Cancer

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Mechanisms of Metastasis in Colorectal Cancer and Metastatic Organotropism: Hematogenous versus Peritoneal Spread

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MiR-124 Radiosensitizes Human Colorectal Cancer Cells by Targeting PRRX1

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Glutamate dehydrogenase is a novel prognostic marker and predicts metastases in colorectal cancer patients

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LIM and SH3 Protein 1 Induces TGFβ-Mediated Epithelial–Mesenchymal Transition in Human Colorectal Cancer by Regulating S100A4 Expression

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The Roles of the Epithelial-Mesenchymal Transition Marker PRRX1 and miR-146b-5p in Papillary Thyroid Carcinoma Progression

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PRRX1 promotes epithelial–mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer

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The AURKA/TPX2 axis drives colon tumorigenesis cooperatively with MYC

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PI3K/AKT signaling pathway as a critical regulator of Cisplatin response in tumor cells

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Molecular features and gene expression signature of metastatic colorectal cancer (Review)

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Prrx1 promotes stemness and angiogenesis via activating TGF-β/smad pathway and upregulating proangiogenic factors in glioma

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LGR5 Is a Gastric Cancer Stem Cell Marker Associated with Stemness and the EMT Signature Genes NANOG, NANOGP8, PRRX1, TWIST1, and BMI1

Wang, B., Chen, Q., Cao, Y., Ma, X., Yin, C., Jia, Y., Zang, A., & Fan, W. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168904 · Cited by 61 · see citing works

miR-30bregulates migration and invasion of human colorectal cancer via SIX1

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Integration of transcriptome and methylome analysis of aldosterone-producing adenomas

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PRRX1 Regulates Cellular Phenotype Plasticity and Dormancy of Head and Neck Squamous Cell Carcinoma Through miR-642b-3p

Jiang, J., Zheng, M., Zhang, M., Yang, X., Li, L., Wang, S.-S., Wu, J.-S., Yu, X.-H., Wu, J.-B., Pang, X., et al. (2019) · Neoplasia · doi:10.1016/j.neo.2018.12.001 · Cited by 54 · see citing works

Exploiting transcription factors to target EMT and cancer stem cells for tumor modulation and therapy

Khan, A. Q., Hasan, A., Mir, S. S., Rashid, K., Shahab Uddin, M. S., & Steinhoff, M. S. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.03.002 · Cited by 57 · see citing works

In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer

Wei, R., Wong, J. P. C., Lyu, P., Xi, X., Tong, O., Zhang, S., Yuen, H. F., Shirasawa, S., & Kwok, H. F. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13686 · Cited by 52 · see citing works

PRRX2 as a novel TGF‐β‐induced factor enhances invasion and migration in mammary epithelial cell and correlates with poor prognosis in breast cancer

Juang, Y., Jeng, Y., Chen, C., & Lien, H. (2016) · Molecular Carcinogenesis · doi:10.1002/mc.22465 · Cited by 49 · see citing works

Tumor dormancy as an alternative step in the development of chemoresistance and metastasis - clinical implications

Rossari, F., Zucchinetti, C., Buda, G., & Orciuolo, E. (2019) · Cellular Oncology · doi:10.1007/s13402-019-00467-7 · Cited by 47 · see citing works

RNA binding protein RBMS3 is a common EMT effector that modulates triple-negative breast cancer progression via stabilizing PRRX1 mRNA

Block, C. J., Mitchell, A. V., Wu, L., Glassbrook, J. E., Craig, D., Chen, W., Dyson, G. E., DeGracia, D. J., Polin, L., Ratnam, M., et al. (2021) · Oncogene · doi:10.1038/s41388-021-02030-x · Cited by 46 · see citing works

PRRX1 isoforms cooperate with FOXM1 to regulate the DNA damage response in pancreatic cancer cells

Marchand, B., Pitarresi, J. R., Reichert, M., Suzuki, K., Laczko, D. I., & Rustgi, A. K. (2019) · Oncogene · doi:10.1038/s41388-019-0725-6 · Cited by 38 · see citing works

Inhibition of PRRX2 suppressed colon cancer liver metastasis via inactivation of Wnt/β-catenin signaling pathway

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Interplay Between Transcription Factors and MicroRNAs Regulating Epithelial-Mesenchymal Transitions in Colorectal Cancer

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Differential role of intravenous anesthetics in colorectal cancer progression: implications for clinical application

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Pre-metastatic niche triggers SDF-1/CXCR4 axis and promotes organ colonisation by hepatocellular circulating tumour cells via downregulation of Prrx1

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SOX9 reprograms endothelial cells by altering the chromatin landscape

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IL1RN and PRRX1 as a Prognostic Biomarker Correlated with Immune Infiltrates in Colorectal Cancer: Evidence from Bioinformatic Analysis

Wang, Q., Huang, X., Zhou, S., Ding, Y., Wang, H., Jiang, W., & Xu, M. (2022) · International Journal of Genomics · doi:10.1155/2022/2723264 · Cited by 35 · see citing works

Downregulation of PRRX1 Confers Cancer Stem Cell-Like Properties and Predicts Poor Prognosis in Hepatocellular Carcinoma

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Mesenchymal Neuroblastoma Cells Are Undetected by Current mRNA Marker Panels: The Development of a Specific Neuroblastoma Mesenchymal Minimal Residual Disease Panel

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Cutaneous basal cell carcinosarcomas: evidence of clonality and recurrent chromosomal losses

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Phenotypic Heterogeneity, Bidirectionality, Universal Cues, Plasticity, Mechanics, and the Tumor Microenvironment Drive Cancer Metastasis

Mierke, C. T. (2024) · Biomolecules · doi:10.3390/biom14020184 · Cited by 32 · see citing works

RNA Demethylase ALKBH5 Prevents Lung Cancer Progression by Regulating EMT and Stemness via Regulating p53

Liu, X., Wang, Z., Yang, Q., Hu, X., Fu, Q., Zhang, X., & Li, W. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.858694 · Cited by 30 · see citing works

Downregulation of UBAP2L Inhibits the Epithelial-Mesenchymal Transition via SNAIL1 Regulation in Hepatocellular Carcinoma Cells

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Quantifying the Epithelial-to-Mesenchymal Transition (EMT) from Bench to Bedside

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NIBP impacts on the expression of E-cadherin, CD44 and vimentin in colon cancer via the NF-κB pathway

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Derivation of a fifteen gene prognostic panel for six cancers

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Serum and tissue markers in colorectal cancer: State of art

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The Regulatory Role of PRRX1 in Cancer Epithelial-Mesenchymal Transition

Du, W., Liu, X., Yang, M. G., Wang, W., & Sun, J. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s316102 · Cited by 25 · see citing works

Paired related homeobox 1 is associated with the invasive properties of glioblastoma cells

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PRRX1‐induced epithelial‐to‐mesenchymal transition in salivary adenoid cystic carcinoma activates the metabolic reprogramming of free fatty acids to promote invasion and metastasis

Jiang, Y., Tang, Y., Wang, S., Wu, J., Zhang, M., Pang, X., Wu, J., Chen, Y., Tang, Y., & Liang, X. (2019) · Cell Proliferation · doi:10.1111/cpr.12705 · Cited by 23 · see citing works

Downregulation of PRRX1 via the p53-dependent signaling pathway predicts poor prognosis in hepatocellular carcinoma

Fan, M., Shen, J., Liu, H., Wen, Z., Yang, J., Yang, P., Liu, K., Chang, Y., Duan, J., & Lü, K. (2017) · Oncology Reports · doi:10.3892/or.2017.5785 · Cited by 22 · see citing works

Population-Specific Genetic and Expression Differentiation in Europeans

Jiang, X., & Assis, R. (2020) · Genome Biology and Evolution · doi:10.1093/gbe/evaa021 · Cited by 18 · see citing works

Long Non-Coding RNAs as Potential Regulators of EMT-Related Transcription Factors in Colorectal Cancer—A Systematic Review and Bioinformatics Analysis

Pavlič, A., Hauptman, N., Boštjančič, E., & Zidar, N. (2022) · Cancers · doi:10.3390/cancers14092280 · Cited by 19 · see citing works

Alternative splicing of DNA damage response genes and gastrointestinal cancers

Rahmutulla, B. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i46.17305 · Cited by 19 · see citing works

PRRX1 isoform PRRX1A regulates the stemness phenotype and epithelial-mesenchymal transition (EMT) of cancer stem-like cells (CSCs) derived from non-small cell lung cancer (NSCLC)

Sun, L., Han, T., Zhang, X., Liu, X., Li, P., Shao, M., Dong, S., & Li, W. (2020) · Translational Lung Cancer Research · doi:10.21037/tlcr-20-633 · Cited by 18 · see citing works

PRRX1 promotes malignant properties in human osteosarcoma

Joko, R., Yamada, D., Nakamura, M., Yoshida, A., Takihira, S., Takao, T., Lu, M., Sato, K., Ito, T., Kunisada, T., et al. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100960 · Cited by 16 · see citing works

Low PRRX1 expression and high ZEB1 expression are significantly correlated with epithelial-mesenchymal transition and tumor angiogenesis in non-small cell lung cancer

Yang, R., Liu, Y., Wang, Y., Wang, X., Ci, H., Song, C., & Wu, S. (2021) · Medicine · doi:10.1097/md.0000000000024472 · Cited by 16 · see citing works

PRRX1 deficiency induces mesenchymal‐epithelial transition through PITX2/miR‐200–dependent SLUG/CTNNB1 regulation in hepatocellular carcinoma

Chen, W., Wu, J., Shi, W., Zhang, G., Chen, X., Ji, A., Wang, Z., Wu, J., & Jiang, C. (2021) · Cancer Science · doi:10.1111/cas.14853 · Cited by 14 · see citing works

The paired‐related homeobox protein 1 promotes cardiac fibrosis via the Twist1‐Prrx1‐tenascin‐C loop

Wang, F.-Y., Zhao, H., Yin, L., Zhang, W., Tang, Y., Wang, X., & Huang, C. (2022) · Cell Biology International · doi:10.1002/cbin.11944 · Cited by 13 · see citing works

Loss of PRRX1 induces epithelial-mesenchymal transition and cancer stem cell-like properties in A549 cells.

Zhu, H., & Sun, G. (2017) · PubMed Central · Cited by 12 · see citing works

PRRX1 promotes lymph node metastasis of gastric cancer by regulating epithelial-mesenchymal transition

Yao, J., Zhang, Y., Xia, Y., Zhu, C., Wen, X., Liu, T., & Da, M. (2021) · Medicine · doi:10.1097/md.0000000000024674 · Cited by 12 · see citing works

The role of PRRX1 in the apoptosis of A549 cells induced by cisplatin.

Zhu, H., Sun, G., Dong, J., & Fei, L. (2017) · Europe PMC (PubMed Central) · Cited by 12 · see citing works

Aberrant expression of vasculogenic mimicry, PRRX1, and CIP2A in clear cell renal cell carcinoma and its clinicopathological significance

Wang, X., Yang, R., Wang, Q., Wang, Y., Ci, H., & Wu, S. (2019) · Medicine · doi:10.1097/md.0000000000017028 · Cited by 11 · see citing works

Paired‑related homeobox 1 overexpression promotes multidrug resistance via PTEN/PI3K/AKT signaling in MCF‑7 breast cancer cells

Luo, H., Cong, S., Dong, J., Jin, L., Jiang, D., Wang, X., Chen, Q., & Li, F. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11414 · Cited by 11 · see citing works

Prospective pathway signaling and prognostic values of MicroRNA-9 in ovarian cancer based on gene expression omnibus (GEO): a bioinformatics analysis

Zuo, L., Li, X., Tan, Y., Zhu, H., & Xiao, M. (2021) · Journal of Ovarian Research · doi:10.1186/s13048-021-00779-z · Cited by 11 · see citing works

PRRX1 promotes colorectal cancer stemness and chemoresistance via the JAK2/STAT3 axis by targeting IL-6

Zhong, L., Tan, W., Yang, Q., Zou, Z., Zhou, R., Huang, Y., Qiu, Z., Zheng, K., & Huang, Z.-H. (2022) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-22-1137 · Cited by 9 · see citing works

LncRNA FEZF1-AS1 promotes colorectal cancer progression through regulating the miR-363-3p/PRRX1 pathway

Zhang, T., Yu, S., & Zhao, S. (2021) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/135693 · Cited by 9 · see citing works

The Epithelial to Mesenchymal Transition in Colorectal Cancer Progression: The Emerging Role of Succinate Dehydrogenase Alterations and Succinate Accumulation

Turano, M., Vicidomini, R., Cammarota, F., D’Agostino, V., Duraturo, F., Izzo, P., & Rosa, M. D. (2023) · Biomedicines · doi:10.3390/biomedicines11051428 · Cited by 8 · see citing works

Exploiting tertiary lymphoid structures gene signature to evaluate tumor microenvironment infiltration and immunotherapy response in colorectal cancer

Xu, Z., Wang, Q., Zhang, Y., Li, X., Wang, M., Zhang, Y., Pei, Y., Li, K., Yang, M., Luo, L., et al. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1383096 · Cited by 8 · see citing works

SPOCK1 silencing decreases 5-FU resistance through PRRX1 in colorectal cancer

Qu, Y.-L., Liu, X., Zhao, S., & Zhai, X. (2022) · Pathology - Research and Practice · doi:10.1016/j.prp.2022.153895 · Cited by 8 · see citing works

Clinicopathologic Correlations of E-cadherin and Prrx-1 Expression Loss in Hepatocellular Carcinoma

Yi, K., Kim, H., Chung, Y., Ahn, H., Sim, J., Wi, Y. C., Pyo, J. Y., Song, Y.-S., Paik, S. S., & Oh, Y. (2016) · Journal of Pathology and Translational Medicine · doi:10.4132/jptm.2016.06.22 · Cited by 7 · see citing works

PRRX1 drives tamoxifen therapy resistance through induction of epithelial-mesenchymal transition in MCF-7 breast cancer cells.

Dong, J., Lv, Z., Chen, Q., Wang, X., & Li, F. (2018) · Europe PMC (PubMed Central) · Cited by 6 · see citing works

PRRX1/FOXM1 reduces gemcitabin-induced cytotoxicity by regulating autophagy in bladder cancer

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An Overview of Epithelial-to-Mesenchymal Transition and Mesenchymal-to-Epithelial Transition in Canine Tumors: How Far Have We Come?

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Therapeutic potential of vasculogenic mimicry in urological tumors

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PRRX1 silencing is required for metastatic outgrowth in melanoma and is an independent prognostic of reduced survival in patients

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Hypomethylation-mediated upregulation of PHOX1 promotes gastric cancer progression via transactivation of NGFR

Li, Y., Liu, W., Zheng, L., Zhu, G., Qian, X., Zeng, R., Xu, Y., Huang, W., Huang, Y., & Zhang, Q.-L. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02811-3 · Cited by 4 · see citing works

A Vaccine against Cancer: Can There Be a Possible Strategy to Face the Challenge? Possible Targets and Paradoxical Effects

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Dysregulated paired related homeobox 1 impacts on hepatocellular carcinoma phenotypes

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Role of microRNA-363 during tumor progression and invasion

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Transcription factor PRRX1-activated ANXA6 facilitates EGFR-PKCα complex formation and enhances cisplatin sensitivity in bladder cancer

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Exploring the Role of Epithelial–Mesenchymal Transition During Colorectal Cancer Peritoneal Metastasis: Update on Their Mechanisms

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Propofol Protects the Blood-Brain Barrier After Traumatic Brain Injury by Stabilizing the Extracellular Matrix via Prrx1: From Neuroglioma to Neurotrauma

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SOX9 acts as a dynamic pioneer factor inducing stable changes in the chromatin landscape to reprogram endothelial cellsPreprint

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Prrx1 promotes mesangial cell proliferation and kidney fibrosis through YAP in diabetic nephropathy

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Expression and clinical significance of paired- related homeobox 1 and Smad2 in gastric cancer

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Epithelial to Mesenchymal Transition (EMT) and Intestinal Tumorigenesis

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Investigation of novel therapeutic strategies for epithelial ovarian cancer

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Paired-related homeobox 1 induces epithelial-mesenchymal transition in oesophageal squamous cancer

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PRRX1 regulates malignancies partially via regulating ANTXR1 and thus activating PI3K/mTOR signaling in hepatocarcinomaPreprint

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Additional file 1 of Dysregulated paired related homeobox 1 impacts on hepatocellular carcinoma phenotypes

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Upregulation of PHOX1 Driven by Hypomethylation Accelerates Gastric Cancer Progression through NGFR Transactivation

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Modulation du phénotype dans les cellules HMEC

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Identification de PRRX1 (Paired Related Homeobox Protein-1), un nouveau facteur de transcription impliqué dans la Fibrose Pulmonaire Idiopathique

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Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

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NFATc1 cooperation with EZH2 hastens oncogenic activity in pancreatic cancer

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The Regulatory Role of PRRX1 in Cancer Epithelial-Mesenchymal Transition

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Loss of PRRX1 induces epithelial-mesenchymal transition and cancer stem cell-like properties in A549 cells.

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