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Focus on the p38 MAPK signaling pathway in bone development and maintenance
Open accessAbstract
The p38 mitogen-activated protein kinase (MAPK) signaling pathway can be activated in response to a wide range of extracellular signals. As a consequence, it can generate many different biological effects that depend on the stimulus and on the activated cell type. Therefore, this pathway has been found to regulate many aspects of tissue development and homeostasis. Recent work with the aid of genetically modified mice has highlighted the physiological functions of this pathway in skeletogenesis and postnatal bone maintenance. In this review, emphasis is given to the roles of the p38 MAPK pathway in chondrocyte, osteoblast and osteoclast biology. In particular, we describe the molecular mechanisms of p38 MAPK activation and downstream targets. The requirement of this pathway in physiological bone development and homeostasis is demonstrated by the ability of p38 MAPK to regulate master transcription factors controlling geneses and functions of chondrocytes, osteoblasts and osteoclasts.
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Citations
Cites
Cellular and molecular mechanisms of bone remodeling
Raggatt, L. J., & Partridge, N. C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r109.041087 · Cited by 1,402
Matsumoto, M., Kogawa, M., Wada, S., Takayanagi, H., Tsujimoto, M., Katayama, S., Hisatake, K., & Nogi, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408795200 · Cited by 436
Cited by
p38 MAPK Signaling in Osteoblast Differentiation
Rodríguez-Carballo, E., Gámez, B., & Ventura, F. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00040 · Cited by 316
Zhai, M., Zhu, Y., Yang, M., & Mao, C. (2020) · Advanced Science · doi:10.1002/advs.202001334 · Cited by 277
Wang, X., Chen, B., Sun, J., Jiang, Y., Zhang, H., Zhang, P., Fei, B., & Xu, Y. (2018) · Metabolism · doi:10.1016/j.metabol.2018.01.005 · Cited by 113
miR-433-3p suppresses bone formation and mRNAs critical for osteoblast function in mice
Garcia, J., Smith, S. S., Karki, S., Drissi, H., Hrdlicka, H. H., Youngstrom, D. W., & Delany, A. M. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4339 · Cited by 16
Metadata
- Authors
- Thouverey, C., & Caverzasio, J.
- Venue
- BoneKEy Reports
- Publisher
- Portico
- Published
- 2015-06-10
- Volume
- 4
- Pages
- 711-711
- ISSN
- 2047-6396 (ISSN-L)
- OpenAlex
- W1600935552
- Cited by
- 162
- References
- 2
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- green
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