The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Intestinal microbiota: a potential target for the treatment of postmenopausal osteoporosis
Open accessAbstract
Postmenopausal osteoporosis (PMO) is a prevalent metabolic bone disease characterized by bone loss and structural destruction, which increases the risk of fracture in postmenopausal women. Owing to the high morbidity and serious complications of PMO, many efforts have been devoted to its prophylaxis and treatment. The intestinal microbiota is the complex community of microorganisms colonizing the gastrointestinal tract. Probiotics, which are dietary or medical supplements consisting of beneficial intestinal bacteria, work in concert with endogenous intestinal microorganisms to maintain host health. Recent studies have revealed that bone loss in PMO is closely related to host immunity, which is influenced by the intestinal microbiota. The curative effects of probiotics on metabolic bone diseases have also been demonstrated. The effects of the intestinal microbiota on bone metabolism suggest a promising target for PMO management. This review seeks to summarize the critical effects of the intestinal microbiota and probiotics on PMO, with a focus on the molecular mechanisms underlying the pathogenic relationship between bacteria and host, and to define the possible treatment options.
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Cited by
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Metadata
- Authors
- Xu, X., Jia, X., Mo, L., Liu, C., Zheng, L., Yuan, Q., & Zhou, X.
- Venue
- Bone Research
- Published
- 2017-10-04
- Volume
- 5
- Issue
- 1
- Pages
- 17046-17046
- ISSN
- 2095-4700 (ISSN-L)
- 2095-6231
- OpenAlex
- W2761895077
- Cited by
- 199
- References
- 39
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- gold
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